Fred Xiaopu ZHOU
周晓璞
PhD in Life Science
The Hong Kong University of Science and Technology, 2018

Research Assistant Professor
Division of Life Science



(852) 3469 2635
xpzhou@ust.hk
Room CYT5008

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Google Scholar
xJFfreAAAAAJ

ORCID
0000-0001-5307-5805

Scopus ID
56843847700




Research Interest Publications Projects




Research Interest

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Genetics
Neuroscience
Neurodegenerative disease
Genomics



Publications

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All Years 25 2022 0 2021 6 2020 2 2019 5 2018 2 2017 0 2016 10

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2021 6

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention
Current Opinion in Neurobiology, v. 69, August 2021, p. 58-67
Zhou, Xiaopu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu Article
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Nature Biomedical Engineering, 26 July 2021
Duan, Yangyang; Ye, Tao; Qu, Zhe; Chen, Yuewen; Miranda, Abigail Orquiza; Zhou, Xiaopu; Lok, Ka Chun; Chen, Yu; Fu, Kit Yu; Gradinaru, Viviana; Ip, Nancy Yuk-yu Article
GSAP Regulates Lipid Homeostasis and Mitochondrial Function Associated with Alzheimer's Disease
Journal of Experimental Medicine, v. 218, (8), June 2021, article number e20202446
Xu, Peng; Chang, Jerry C.; Zhou, Xiaopu; Wang, Wei; Bamkole, Michael; Wong, Eitan; Bettayeb, Karima; Jiang, Lu-Lin; Huang, Timothy; Luo, Wenjie; Xu, Huaxi; Nairn, Angus C.; Flajolet, Marc; Ip, Nancy Yuk-yu; Li, Yue-Ming; Greengard, Paul Article
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging
Alzheimer's and Dementia, 25 May 2021
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu Article
Polygenic Score Models For Alzheimer’s Disease: From Research To Clinical Applications
Frontiers in Neuroscience, v. 15, 29 March 2021, article number 650220
Zhou, Xiaopu; Li, Yolanda Yuen Tung; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu Article
Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population
2021 Alzheimer's Association International Conference, Denver, Colorado, USA , 26-30 July 2021
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Chit Hang; Lo, Ming Nok; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu Conference paper

2020 2

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu Article
Evaluation of genetic risk for Alzheimer’s disease in the Hong Kong Chinese population
Alzheimer's Association International Conference (AAIC 2020), Online Conference, 26-30 July 2020
Zhou, Xiaopu Conference paper

2019 5

Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease
ACS Chemical Neuroscience, v. 10, (9), August 2019, p. 3986-3996
Chen, Yuewen; Xu, Jinying; Zhou, Xiaopu; Liu, Saijuan; Zhang, Yulin; Ma, Shuangshuang; Fu, Kit Yu; Ip, Nancy Yuk-yu; Chen, Yu Article
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu Article
Deregulation of IL-33/ST2 signaling in Alzheimer’s disease
Gordon Research Conference on Cognitive Dysfunction in Brain Diseases, Hong Kong, 12-17 May 2019
Jiang, Yuanbing; Zhou, Xiaopu; Wang, Ye; Lai, N.C.H.; Tong, Pui Sze; Mok, V.C.T.; Kwok, T.C.Y.; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
International Alzheimer’s Disease Conference 2019, Hong Kong, 31 May – 1 June 2019
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu Conference paper
Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population
Gordon Research Conference on Cognitive Dysfunction in Brain Diseases, Hong Kong, 12-17 May 2019
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper

2018 2

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), Feb 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu Article
Identification of Genetic Risk Factors for Alzheimer’s Disease in The Chinese Population
Alzheimer's Association International Conference (AAIC 2018), Chicago, Illinois, 22-26 July 2018
Zhou, Xiaopu Conference paper

2016 6

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu Article
Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu Conference paper
IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12 - 16 November 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu Conference paper
IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, The Hong Kong University of Science and Technology, June, 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu Conference paper
IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, Hong Kong, 12-17 June 2016
Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu Conference paper
IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu Conference paper

2015 4

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling
PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu Article
Cdk5 regulates activity-dependent gene expression and dendrite development
Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu Article
Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development
2015 Modulation of Neural Circuits & Behavior GRC: Neuromodulatory Signaling Pathways that Modify the Function of Circuits, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 21-26 June, 2015
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper
Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development
The 45th Annual Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21 October 2015
Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper


Expand All Collapse All


Article 5

APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention
Current Opinion in Neurobiology, v. 69, August 2021, p. 58-67
Zhou, Xiaopu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Nature Biomedical Engineering, 26 July 2021
Duan, Yangyang; Ye, Tao; Qu, Zhe; Chen, Yuewen; Miranda, Abigail Orquiza; Zhou, Xiaopu; Lok, Ka Chun; Chen, Yu; Fu, Kit Yu; Gradinaru, Viviana; Ip, Nancy Yuk-yu
GSAP Regulates Lipid Homeostasis and Mitochondrial Function Associated with Alzheimer's Disease
Journal of Experimental Medicine, v. 218, (8), June 2021, article number e20202446
Xu, Peng; Chang, Jerry C.; Zhou, Xiaopu; Wang, Wei; Bamkole, Michael; Wong, Eitan; Bettayeb, Karima; Jiang, Lu-Lin; Huang, Timothy; Luo, Wenjie; Xu, Huaxi; Nairn, Angus C.; Flajolet, Marc; Ip, Nancy Yuk-yu; Li, Yue-Ming; Greengard, Paul
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging
Alzheimer's and Dementia, 25 May 2021
Jiang, Yuanbing; Zhou, Xiaopu; Ip, Fanny Chui Fun; Chan, Philip; Chen, Yu; Lai, Nicole C. H.; Cheung, Kit; Lo, Ronnie M. N.; Tong, Pui Sze; Wong, Bonnie W. Y.; Chan, Andrew L. T.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Mok, Kin Ying Boniface; Hardy, John; Zetterberg, Henrik; Fu, Kit Yu; Ip, Nancy Yuk-yu
Polygenic Score Models For Alzheimer’s Disease: From Research To Clinical Applications
Frontiers in Neuroscience, v. 15, 29 March 2021, article number 650220
Zhou, Xiaopu; Li, Yolanda Yuen Tung; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu

Conference paper 1

Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population
2021 Alzheimer's Association International Conference, Denver, Colorado, USA , 26-30 July 2021
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Jiang, Yuanbing; Cao, Han; Zhong, Huan; Chen, Yuewen; Chen, Jiahang; Zhang, Yulin; Ma, Shuangshuang; Lai, Chit Hang; Lo, Ming Nok; Cheung, Kit; Tong, Pui Sze; Mok, Kin Ying Boniface; Hardy, John; Guo, Qihao; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Chen, Lei; Fu, Kit Yu; Ip, Nancy Yuk-Yu


Expand All Collapse All


Article 1

Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, v. 12, (1), August 2020, article number e12074
Zhou, Xiaopu; Chen, Yu; Ip, Fanny Chui Fun; Lai, Nicole C.H.; Li, Yuen Tung; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronie M.N.; Cheung, Kit; Tong, Pui Sze; Ko, Ho; Shoai, Maryam; Mok, Kin Ying Boniface; Hardy, John; Mok, Vincent C.T.; Kwok, Timothy C.Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu

Conference paper 1

Evaluation of genetic risk for Alzheimer’s disease in the Hong Kong Chinese population
Alzheimer's Association International Conference (AAIC 2020), Online Conference, 26-30 July 2020
Zhou, Xiaopu


Expand All Collapse All


Article 2

Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease
ACS Chemical Neuroscience, v. 10, (9), August 2019, p. 3986-3996
Chen, Yuewen; Xu, Jinying; Zhou, Xiaopu; Liu, Saijuan; Zhang, Yulin; Ma, Shuangshuang; Fu, Kit Yu; Ip, Nancy Yuk-yu; Chen, Yu
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
Nature Communications, v. 10, (1), December 2019, article number 3310
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Chui Fun Fanny; Chen, Yuewen; Mullapudi, Nandita; Giusti-Rodríguez, Paola; Sullivan, Patrick F.; Hardy,John; Fu, Kit Yu; Li, Yun; Ip, Nancy Yuk-yu

Conference paper 3

Deregulation of IL-33/ST2 signaling in Alzheimer’s disease
Gordon Research Conference on Cognitive Dysfunction in Brain Diseases, Hong Kong, 12-17 May 2019
Jiang, Yuanbing; Zhou, Xiaopu; Wang, Ye; Lai, N.C.H.; Tong, Pui Sze; Mok, V.C.T.; Kwok, T.C.Y.; Ip, Fanny Chui Fun; Fu, Kit Yu; Ip, Nancy Yuk-yu
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
International Alzheimer’s Disease Conference 2019, Hong Kong, 31 May – 1 June 2019
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Kwok, T.C.Y.; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Mullapudi, Nandita; Hardy, J.; Fu, Kit Yu; Li, Y.; Ip, Nancy Yuk-yu
Whole-genome sequencing for Alzheimer’s disease risk in the Chinese population
Gordon Research Conference on Cognitive Dysfunction in Brain Diseases, Hong Kong, 12-17 May 2019
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Mok, V.C.T.; Guo, Q.; Ip, Fanny C.F.; Chen, Y.; Hardy, J.; Li, Y.; Fu, Kit Yu; Ip, Nancy Yuk-yu


Expand All Collapse All


Article 1

Identification of Genetic Risk Factors in The Chinese Population Implicates a Role of the Immune System in Alzheimer’s Disease Pathogenesis
Proceedings of the National Academy of Sciences of the United States of America, v. 115, (8), Feb 2018, p. 1697-1706
Zhou, Xiaopu; Chen, Yu; Mok, Kin Ying Boniface; Zhao, Qianhua; Chen, Keliang; Chen, Yuewen; Hardy, John; Li, Yun; Fu, Kit Yu; Guo, Qihao; Ip, Nancy Yuk-yu

Conference paper 1

Identification of Genetic Risk Factors for Alzheimer’s Disease in The Chinese Population
Alzheimer's Association International Conference (AAIC 2018), Chicago, Illinois, 22-26 July 2018
Zhou, Xiaopu


Expand All Collapse All


Article 1

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu

Conference paper 5

Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu
IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12 - 16 November 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu
IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, The Hong Kong University of Science and Technology, June, 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu
IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, Hong Kong, 12-17 June 2016
Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu
IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu


Expand All Collapse All


Article 2

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling
PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu
Cdk5 regulates activity-dependent gene expression and dendrite development
Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu

Conference paper 2

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development
2015 Modulation of Neural Circuits & Behavior GRC: Neuromodulatory Signaling Pathways that Modify the Function of Circuits, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 21-26 June, 2015
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu
Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development
The 45th Annual Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21 October 2015
Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu


Expand All Collapse All


2016 6

IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
Proceedings of the National Academy of Sciences of the United States of America, v. 113, (19), May 2016, p. 2705-2713
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu Article
Fine Mapping of the APOE Locus by Low-pass Whole-genome Sequencing in Chinese Alzheimer’s Disease Patients
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Zhou, Xiaopu; Chen, Yu; Zhao, Q.; Chu, M.K.M.; Kwok, C.T.; Mok, K.Y.; Zhang, B.; Fu, Kit Yu; Li, Y.; Guo, Q.; Ip, Nancy Yuk-yu Conference paper
IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12 - 16 November 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Yuk-yu Conference paper
IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, The Hong Kong University of Science and Technology, June, 2016
Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-yu Conference paper
IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model
Molecular & Cellular Neurobiology, Gordon Research Conference, Hong Kong, 12-17 June 2016
Zhou, Xiaopu; Ip, Nancy Yuk-yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu Conference paper
IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model
The 46th Annual Meeting of the Society for Neuroscience, San Diego, USA, 12-16 November 2016
Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Yuk-yu Conference paper

2015 4

Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling
PLoS ONE, v. 10, (7), July 2015, article number e0133115
Chen, Yu; Liang, Zhuoyi; Fei, Erkang; Chen, Yuewen; Zhou, Xiaopu; Fang, Weiqun; Fu, Wing-Yu; Fu, Amy Kit Yu; Ip, Nancy Yuk-yu Article
Cdk5 regulates activity-dependent gene expression and dendrite development
Journal of Neuroscience, v. 35, (45), November 2015, p. 15127-15134
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk Yu Article
Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development
2015 Modulation of Neural Circuits & Behavior GRC: Neuromodulatory Signaling Pathways that Modify the Function of Circuits, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 21-26 June, 2015
Liang, Zhuoyi; Ye, Tao; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper
Role of Cdk5 in Activity-Induced Gene Expression and Dendrite Development
The 45th Annual Meeting of the Society for Neuroscience, Chicago, USA, 17 - 21 October 2015
Ye, Tao; Liang, Zhuoyi; Zhou, Xiaopu; Lai, Kwok On; Fu, Kit Yu; Ip, Nancy Yuk-yu Conference paper


No Publications


No Publications









ProjectsFrom January 2020 to December 2022

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All Projects 7 Leading Projects 1 Participating Projects 6

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A Randomized-Controlled Trial of Trazodone on Reducing Plasma sST2 Level and Neurodegeneration Progression in Patients with Amnestic Mild Cognitive Impairment and Obstructive Sleep Apnea


曲唑酮降低轻度认知功能障碍和阻塞性睡眠呼吸暂停患者血浆sST2水平和神经退化的随机对照试验 Participating


Innovation and Technology Fund, Morningside Life Science Limited


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
ZHOU Fred Xiaopu


2021 -




Development Of A Blood-based Proteome Biomarker Panel For Alzheimer's Disease In Chinese


阿尔茨海默病相关血液蛋白质组学生物标志物的研发 Participating


Innovation and Technology Fund


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
FU Amy Kit Yu
ZHOU Fred Xiaopu


2021 -




Regulation of the pathogenesis of Alzheimer's disease by SORL1 genetic variants


SORL1基因突变调控阿尔茨海默症病变发生的分子机制 Leading


Shenzhen Science and Technology Innovation Strategy Research and Technology Transfer Promotion Center


Project Team (HKUST)
ZHOU Fred Xiaopu (Lead)


2021 -




Study on the biomarkers for neurodegenerative diseases


神经退行性疾病的生物标志物研究 Participating


Guangdong Natural Science Foundation


Project Team (HKUST)
FU Amy Kit Yu
IP Nancy Yuk-Yu
ZHOU Fred Xiaopu


2020 -




Modelling and application of risk assessment based on molecular biomakers


基于生物标志物的风险评估模型建立和应用 Participating


Shenzhen Science and Technology Innovation Committee


Project Team (HKUST)
CHEUNG Tom (Lead)
ZHOU Fred Xiaopu


2020 -




Multi-dimensional analysis of biomarkers for Alzheimer's disease in the Chinese population


中国人群阿尔茨海默症多维度生物标志物综合研究 Participating


Ministry of Science and Technology of the People's Republic of China


Project Team (HKUST)
CHEUNG Tom
IP Nancy Yuk-Yu
ZHOU Fred Xiaopu


2019 -




The Research on diagnosis and treatment of Alzheimer's disease


阿尔茨海默症的诊治方法研究 Participating


Department of Science and Technology of Guangdong Province


Project Team (HKUST)
IP Nancy Yuk-Yu (Lead)
CHEUNG Tom
FU Amy Kit Yu
LIU Kai
WONG Yung Hou
WU Zhenguo
ZHOU Fred Xiaopu


2018 -