Robert Kam Ming KO
高锦明
PhD in Pharmacology
The University of British Columbia, 1990

Associate Head and Professor
Division of Life Science

Associate Director of Center for Chinese Medicine Research and Development



(852) 2358 7298
bcrko@ust.hk
Room 5534
Personal Web

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ORCID
0000-0001-6673-438X

Scopus ID
7202689231




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Traditional Chinese herbal medicine
Pharmacological basis of Yang / Qi and Yin / blood Chinese tonifying herbs



Publications

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All Years 221 2022 0 2021 3 2020 3 2019 6 2018 5 2017 4 2016 200

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2021 3

Antioxidant and Immunopotentiating Effects of Cordyceps Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models
Chinese Medicine, v. 12, (1), Mach 2021, p. 1-9
Leung, Hoi Yan; Yan, Choly Tat Ming; Ko, Kam Ming Article
Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice
Evidence-based Complementary and Alternative Medicine, v. 2021, February 2021, article number 8858962
Wang, Xiao-Yan; Song, Xue-Lan; Zhang, Yi; Luo, Gan; Tai, Hai-Chuan; Lin, Zhao-Heng; Zhu, Pei-Li; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Pan, Si-Yuan; Tang, Jin-Fa; Ko, Kam Ming Article
The Use Of Chinese Yang/Qi-Invigorating Tonic Botanical Drugs/Herbal Formulations In Ameliorating Chronic Kidney Disease By Enhancing Mitochondrial Function
Frontiers in Pharmacology, v. 12, 24 June 2021, article number 622498
Tian, Jiayi; Huang, Yuqi; Wu, Tong; Huang, Hsien-Da; Ko, Kam Ming; Zhu, Bao Ting; Chen, Jihang Article

2020 3

A unifying theory of aging between modern medicine and traditional Chinese medicine
Chinese Medicine, v. 11, (2), June 2020, p. 105-112
Cheung, Kai Chit; Leung, Hoi Yan; Ko, Robert Kam Ming Article
Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma
Molecules, v. 25, (18), September 2020, article number 4051
Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Leong, Pou Kuan; Yan, Choly Tat Ming; Ko, Kam Ming Article
Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways
FASEB Journal, v. 34, (3), March 2020, p. 4311-4328
Yu, Xiaodan; Xu, Li Miranda; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Duan, Ran; Dong Ting Xia; Ko, Kam Ming; Tsim, Karl Wah Keung Article

2019 6

48Biochemical Mechanisms of the Anti-Obesity Effect of a Triterpenoid-Enriched Extract of Cynomorium Songaricum in Mice With High-Fat-Diet-Induced Obesity
Phytomedicine, v. 73, July 2020, article number 153038
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Wong, Hoi Shan; Ko, Robert Kam Ming Article
A Chinese Herbal Formulation, Xiao-Er-An-Shen Decoction, Attenuates Tourette Syndrome, Possibly by Reversing Abnormal Changes in Neurotransmitter Levels and Enhancing Antioxidant Status in Mouse Brain
Frontiers in Pharmacology, v. 10, July 2019, article number 812
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Li, Zhonggui; Qiu, Jingyu; Ko, Kam Ming; Chen, Jianping Article
Pharmacological Investigation of “Meridian Tropism” in Three “Shen” Chinese Herbs
Chinese Medicine, v. 10, (4), December 2019, p. 121-135
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming Article
Yang/Qi-invigorating herbs for the prevention and/or treatment of diabetic complications
Longhua Chinese Medicine, v. 2, March 2019, article number 4
Leong, Pou Kuan; Ko, Robert Kam Ming Article
基于脂质代谢组学评价五味子素B诱导的急性高甘油三酯血症小鼠模型
中国药理学通报=Chinese Pharmacological Bulletin, v. 35, (6), 2019, p. 833-839
王晓艳; 储着胜; 张辉; 张书琦; 潘思源; 唐进法; 高锦明 Article
Corylin induces bone differentiation and metabolic profiling: illustration by using cultured osteoblasts and bone micromass
15th International Postgraduate Symposium on Chinese Medicine, IPSCM 2019 第15届国际研究生中医药研讨会, Hong Kong, 15-16 August 2019
Yu, Xiaodan; Xu, Li; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung Conference paper

2018 5

Differences in the mechanisms by which Yang-invigorating and Qi-invigorating Chinese tonifying herbs stimulate mitochondrial ATP generation capacity
Chinese Medicine, v. 9, (2), 2018, p. 63-74
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming Article
Shengmai San: a modern medicine perspective on its remedial effects on Qi and Yin deficiency syndrome in Chinese medicine
Longhua Chinese Medicine, v. 1, 20 September 2018, article number 13
Leong, Pou Kuan; Ko, Robert Kam Ming Article
Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases
Natural Products and Drug Discovery: An Integrated Approach / Edited by: Subhash C. Mandal, Vivekananda Mandal and Tetsuya Konishi. Elsevier, 2018, p. 73-104, Ch. 4
Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming Book chapter
Corylin induced the differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures
The 6th International Symposium on Edible & Medical Plant Resources and the Bioactive Ingredients, ISEPR2018, Nanjing, China, 14-17 October 2018
Yu, Xiaodan; Xu, Li; Yao, Ping; Dai, Kun; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung Conference paper
Stimulatory effects of corylin on differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures
International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2018: Inheritance and Innovation - In Commemoration of the 500th Anniversary of the Birth of Li Shizhen, Hong Kong, Hong Kong, 16-17 August 2018
Yu, Xiaodan; Xu, Li; Yao, Ping; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung Conference paper

2017 4

Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo
Antioxidants, v. 6, (2), June 2017, article number 28
Leong, Pou Kuan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Chan, Lincoln; Ko, Kam Ming Article
Biochemical Mechanism Underlying Hypertriglyceridemia and Hepatic Steatosis/Hepatomegaly Induced by Acute Schisandrin B Treatment in Mice
Lipids in Health and Disease, v. 16, (1), January 2017, p. 1-15
Zhang, Yi; Zhao, Jing; Zhou, Shufeng; Yu, Zhiling; Wang, Xiaoyan; Zhu, Peili; Chu, Zhusheng; Pan, Siyuan; Xie, Ming; Ko, Kamming Article
Inter-organ relationships among gut, lung and skin beyond the pathogenesis of allergies: Relevance to the Zang-Fu Theory in Chinese medicine
Chinese Medicine, v. 8, (3), 2017, article number 78205, p. 73-81
Leung, Hiu Yu Cherie; Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming Article
Ursolic Acid Induces Mitochondrial Biogenesis Through the Activation of AMPK and PGC-1 in C2C12 myotubes: A possible Mechanism Underlying its Beneficial Effect on Exercise Endurance
Food and Function, v. 8, (7), 2017, p. 2425-2436
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wingman; Ko, Robert K M Article

2016 7

A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration
PLoS One, v. 11, (3), March 2016, article number e0149663
Zhang, Liyun; Xiang, Lue; Liu, Yiwen; Venkatraman, Prahatha; Chong, Leelyn; Cho, Jin; Bonilla, Sylvia; Jin, Zi-Bing; Pang, Chi Pui; Ko, Robert K.M.; Ma, Ping; Zhang, Mingzhi; Leung, Yuk Fai Article
An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents
Chinese Medicine, v. 7, December 2016, p. 153-165
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Jihang; Zhu, Huawei; Ning, Jialing; Yang, Yiting; Ma, Chung Wah; Ko, Robert Kam Ming Article
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response
PLoS ONE, v. 11, (5), May 2016, article number e0155879
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Ko, Kam Ming Article
Induction of the Glutathione Antioxidant Response/Glutathione Redox Cycling by Nutraceuticals: Mechanism of Protection against Oxidant-induced Cell Death
Current Trends in Nutraceuticals, v. 1, (1-2), March 2016, p. 1-9
Leong, Pou Kuan; Ko, Robert Kam Ming Article
Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease
Oxidative Medicine and Cellular Longevity, v. 2016, 2016, article number 6171658
Leong, Pou Kuan; Ko, Kam Ming Article
Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective
Chinese Medicine, v. 7, (3), August 2016
Chung, Yin Kwan; Chen, Jihang; Ko, Robert Kam Ming Article
β-Sitosterol increases mitochondrial electron transport by fluidizing mitochondrial membranes and enhances mitochondrial responsiveness to increasing energy demand by the induction of uncoupling in C2C12 myotubes
Journal of Functional Foods, v. 23, May 2016, p. 253-260
Wong, Hoi Shan; Leong, Pou Kuan; Chen, Jihang; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article

2015 17

A cistanches herba fraction/ β -sitosterol causes a redox-sensitive induction of mitochondrial uncoupling and activation of adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 in C2C12 myotubes: A possible mechanism underlying the weight reduction effect
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 142059
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming Article
A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice
Lipids in Health and Disease, v. 14, (1), August 2015, article number 97
Chu, Zhusheng; Yu, Zhiling; Pan, Siyuan; Jia, Zhanhong; Wang, Xiaoyan; Zhang, Yi; Zhu, Peili; Wang, Xiujuan; Ko, Kamming Article
A traditional Chinese medicine approach in treating depression by promoting liver Qi circulation: A western medicine perspective
Chinese Medicine, v. 6, (4), November 2015, p. 187-195
So, Raphaella Wai Lam; Wong, Hoi Shan; Ko, Robert K.M. Article
Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice
Drug Design, Development and Therapy, v. 9, February 2015, p. 923-935
Zhu, Pei-Li; Pan, Si-Yuan; Zhou, Shu-Feng; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming Article
Evaluation of a topical herbal agent for the promotion of bone healing
Evidence-based Complementary and Alternative Medicine, v. 2015, February 2015, article number 905270
Siu, Wingsum; Ko, Chunhay; Lam, Ka Wing; Wat, Elaine C.L.; Shum, Waiting; Lau, Clara; Ko, Kam Ming; Hung, Leung Kim; Lau, David Tai Wai; Leung, Pingchung Article
Hawthorn Nectar Enhances Gastrointestinal Motility as Well as Stimulates Intestinal Amylase and Lipase Activities in Mice
Chinese Medicine, v. 6, September 2015, article number 59435, p. 159-168
Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Poukuan; Leung, Hoiyan; Chan, Wingman; Wong, Hoi Shan; Ko, Robert K.M. Article
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan Article
Lily bulb nectar produces expectorant and anti-tussive activities, and suppresses cigarette smoke-induced inflammatory response in the respiratory tract in mice
Chinese Medicine, v. 6, June 2015, article number 56861, p. 136-146
Wong, Hoi Shan; Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article
Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells
Food and Function, v. 6, (2), February 2015, p. 549-557
Chen, Jihang; Wong, Hoi Shan; Ko, Kam Ming Article
New perspectives on dietary-derived treatments and food safety – Antinomy in a new era
Critical Reviews in Food Science and Nutrition, v. 55, (13), November 2015, p. 1836-1859
Pan, Si-Yuan; Gao, Si-Hua; Lin, Rui-Chao; Zhou, Shu-Feng; Dong, Hong-Guan; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M. Article
Schisandrin B Ameliorates ICV-Infused Amyloid beta Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-kappa B/MAPK and Up-Regulating HSP/Beclin Expression
PLoS One, v. 10, (11), November 2015, article number e0142483
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Arumugam, Somasundaram; Mizuno, Makoto; Nawa, Hiroyuki; Suzuki, Kenji; Ko, Robert K.M.; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya Article
Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo
BioFactors, v. 41, (5), September 2015, p. 314-323
Leong, Pou-Kuan; Ko, Kam-Ming Article
Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity
Drug Design, Development and Therapy, v. 9, April 2015, p. 2001-2027
Zhang, Yi; Zhou, Zhiwei; Jin, Hua; Hu, Chengbin; He, Zhixu; Yu, Zhiling; Ko, Robert K.M.; Yang, Tianxin; Zhang, Xueji; Pan, Siyuan; Zhou, Shufeng Article
Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling
PLoS ONE, v. 10, (3), March 2015, article number e0119214
Thandavarayan, Rajarajan A.; Giridharan, Vijayasree V.; Arumugam, Somasundaram; Suzuki, Kenji; Ko, Kam Ming; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya Article
Yang/Qi invigoration: An herbal therapy for chronic fatigue syndrome with yang deficiency?
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 945901
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Ko, Kam Ming Article
Schisandra Chinensis: An Herb of North Eastern China Origin
Schisandra Chinensis: An Herb of North Eastern China Origin / by Kam-Ming Ko , Jun Yin and Chuixin Qin. Singapore: World Scientific Publishing, 2015.
Ko, Kam Ming; Yin, Jun; Qin, Chuixin Book
An investigation of anti-inflammatory activities produced by schisandrin A and schisandrin B in vitro and in vivo
12th World Congress on Inflammation, Boston, MA, USA, 8-12 August 2015
Leong, Pou Kuan; Ko, Robert K.M. Conference paper

2014 17

Acute and Long-term Treatment with an Herbal Formula V-Vital Capsule Increase Exercise Endurance Capacity in Weight-loaded Swimming Mice
Chinese Medicine, v. 5, (3), September 2014, p. 153-164
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Ji Hang; Wong, Hoi Shan; Ma, Chung Wah; Zou, Shi Yu; Ko, Robert K.M. Article
An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 9, July 2014, p. 211-224
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Ko, Robert Kam Ming Article
An ursolic acid-enriched extract of Cynomorium songaricum protects against carbon tetrachloride hepatotoxicity and gentamicin nephrotoxicity in rats possibly through a mitochondrial pathway: A comparison with ursolic acid
Journal of Functional Foods, v. 7, (1), 2014, p. 330-341
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Chen, Na; Ko, Kam Ming Article
Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 10, September 2014, p. 292-304
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article
Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet
Lipids in Health and Disease, v. 13, (1), March 2014, article number 46
Sun, Nan; Pan, Si-Yuan; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Zhou, Shu-Feng; Ko, Robert K M Article
Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 525340
Pan, Si-Yuan; Litscher, Gerhard; Gao, Si-Hua; Zhou, Shu-Feng; Yu, Zhi-Ling; Chen, Hou-Qi; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ko, Kam-Ming Article
Long-term Treatment with an Herbal Formula MCC Ameliorates Obesity-associated Metabolic Dysfunction in High Fat Diet-induced Obese Mice: a Comparative Study among MCC and Various Combinations of its Constituents
Chinese Medicine, v. 5, (1), March 2014, article number 44280, p. 34-46
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Ma, Chung Wah; Yang, Yi Ting; Ko, Robert K.M. Article
New insights into the chemical and biochemical basis of the "yang-invigorating" action of chinese yang-tonic herbs
Evidence-based Complementary and Alternative Medicine, v. 2014, December 2014, article number 856273
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming Article
Quality Assurance of Chinese Herbal Medicines: Procedure for Multiple-Herb Extraction
AIChE journal, v. 60, (12), December 2014, p. 4014-4026
Lau, Yeuk Tin; Ng, Ka Ming; Chen, Na; Lau, David T.W.; Ko, Robert K.M.; Leung, Ping Chung; Wibowo, Christianto Article
Schisandrin B enhances glutathione redox cycling and protects against β-amyloid-induced apoptosis in human neuroblastoma SH-SY5Y cells: A comparative study of various phytochemicals
The Open Nutraceuticals Journal, v. 7, (1), December 2014 , p. 49-57
Leong, Pou Kuan; Lam,Yeung; Chen, Na; Ko, Kam Ming Article
Supplementation with the Extract of Schisandrae Fructus Pulp, Seed, or Their Combination Influences the Metabolism of Lipids and Glucose in Mice Fed with Normal and Hypercholesterolemic Diet
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 472638
Wang, Xiao-Yan; Yu, Zhi-Ling; Pan, Si-Yuan; Zhang, Yi; Sun, Nan; Zhu, Pei-Li; Jia, Zhan-Hong; Zhou, Shu-Feng; Ko, Kam-Ming Article
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
Drug Design, Development and Therapy, v. 8, September 2014, p. 1429-1439
Zhang, Yi; Pan, Si-Yuan; Zhou, Shu-Feng; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming Article
Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells
Molecules, v. 19, January 2014, p. 1576-1591
Chen, Jihang; Wong, Hoi Shan; Ko, Robert Kam Ming Article
β-Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts
PTR. Phytotherapy research, v. 28, (7), July 2014, p. 999-1006
Wong, Hoi Shan; Chen, Na; Leong, Pou Kuan; Ko, Robert Kam Ming Article
β-Sitosterol Protects against Carbon Tetrachloride Hepatotoxicity but not Gentamicin Nephrotoxicity in Rats via the Induction of Mitochondrial Glutathione Redox Cycling
Molecules, v. 19, (11), October 2014, p. 17649-17662
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming Article
Pharmacological profile of dibenzocyclooctadiene lignans and other active ingredients in Schisadrae Fructus
Schisandra Chinensis: An Herb of North Eastern China Origin / By Kam-Ming Ko, Jun Yin, Chuixin Qin. World Scientific, 2014, p. 97-138, Ch. 4
Ko, Robert K.M.; Chen, Na; Leong, Pou Kuan; Ma, Chung Wah Book chapter
Schisandrin B suppresses the lipopolysaccharide/ATP-induced Inflammasome Activation and Cytotoxicity in Isolated Mouse Peritoneal Macrophages and Cultured RAW264.7 Macrophages via Eliciting Nrf2-driven Antioxidant Response
The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, Hong Kong, 15-16 November 2014
Leong, Pou Kuan; Ko, Kam Ming Conference paper

2013 7

A Novel Mouse Model of Combined Hyperlipidemia Associated With Steatosis and Liver Injury by a Single-Dose Intragastric Administration of Schisandrin B/Cholesterol/Bile Salts Mixture
Journal of Pharmacological Sciences, v. 123, (2), 2013, p. 110-119
Pan, Si-Yuan; Jia, Zhan-Hong; Zhang, Yi; Yu, Qing; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Yu, Zhi-Ling; Ko, Robert K.M. Article
Caspase-3-Dependent Apoptosis of Citreamicin ε-Induced HeLa Cells Is Associated with Reactive Oxygen Species Generation
Chemical Research in Toxicology, v. 26, (7), July 2013, p. 1055-1063
Liu, Lingli; He, Lisheng; Xu, Sharon Ying; Han, Zhuang; Li, Yongxin; Zhong, Jialiang; Guo, Xianrong; Zhang, Xixiang; Ko, Robert K.M.; Qian, Peiyuan Article
Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes
Pharmaceutical Biology, v. 51, (1), 2013, p. 64-73
Wong, Hoi Shan; Ko, Robert K.M. Article
Long-Term Treatment with an Herbal Formula MCC Reduces the Weight Gain in High Fat Diet-Induced Obese Mice
Chinese Medicine, v. 4, (3), September 2013, article number 36112, p. 63-71
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Ma, Chung Wa; Yang, Yiting; Ko, Robert K.M. Article
New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics
Evidence-based Complementary and Alternative Medicine, v. 2013, 2013, article number 627375
Pan, Si-Yuan; Zhou, Shu-Feng; Gao, Si-Hua; Yu, Zhi-Ling; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ma, Dik-Lung; Han, Yi-Fan; Fong, Wang-Fun; Ko, Robert K.M. Article
Schisandrin B enhances hepatic/myocardial glutathione regeneration capacity and protects against oxidant injury in rat livers and hearts
The Open Nutraceuticals Journal, v. 6, (1), 2013, p. 124-128
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling
Evidence-Based Complementary and Alternative Medicine, v. 2013, March 2013, article number 924128
Chen, Jihang; Ko, Robert K.M. Article

2012 15

"Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situ and Rat Hearts ex Vivo
Chinese Medicine, v. 3, (2), June 2012, p. 101-105
Wong, Hoi Shan; Cheung, Weng Fat; Tang, Wai Ling; Ko, Robert K.M. Article
A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs
Chinese Medicine, v. 3, (1), March 2012, article number 18126
Lam, Yeung; Wong, Hoi Shan; Chen, Jihang; Ko, Robert K.M. Article
Beneficial effect of (-)Schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells
BioFactors, v. 38, (3), May/June 2012, p. 219-225
Lam, Yeung; Ko, Robert K.M. Article
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes
Cell Biology International, v. 36, (3), March 2012, p. 321-326
Leong, Pou Kuan; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes
Indian Journal of Pharmacology, v. 44, (2), March 2012, p. 204-209
Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity
Lipids in Health and Disease, v. 11, September 2012, article number 120
Pan, Si-Yuan; Yu, Qing; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Yu, Zhi-Ling; Ko, Robert K.M. Article
Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
Journal of Complementary and Integrative Medicine, v. 9, (1), November 2012
Leung, Hoi Yan; Ko, Robert K.M. Article
Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases
Clinical and Experimental Pharmacology & Physiology, v. 39, (3), March 2012, p. 256-264
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity
Journal of Medicinal Food, v. 15, (7), June 2012, p. 629-638
Lam, Yeung; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
New Perspectives on Complementary and Alternative Medicine: An Overview and Alternative Therapy
Alternative Therapies in Health and Medicine, v. 18, (4), July 2012, p. 20-36
Pan, Si-Yuan; Gao, Si-Hua; Zhou, Shu-Feng; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M. Article
Product Design: A Nanomized Nutraceutical with Enhanced Bioactivity and Bioavailability
Industrial & Engineering Chemistry Research, v. 51, (21), May 2012, p. 7320-7326
Lau, Yeuk Tin; Chen, Na; Ko, Robert K.M.; Ng, Ka Ming Article
Prooxidant-Induced Glutathione Antioxidant Response in Vitro and in Vivo: A Comparative Study between Schisandrin B and Curcumin
Biological and Pharmaceutical Bulletin, v. 35, (4), April 2012, p. 464-472
Leong, Pou Kuan; Chiu, Po Yee; Ko, Robert K.M. Article
Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases
Oxidative Medicine and Cellular Longevity, v. 2012, March 2012, article number 250825
Lam, Yeung; Ko, Robert K.M. Article
Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice
Free Radical Research, v. 46, (1), January 2012, p. 50-60
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Bhilwade, Hari N.; Ko, Robert K.M.; Watanabe, Kenichi; Konishi, Tetsuya Article
五味子及其成分的药理毒理研究
东北道地药材-五味子 - Schisandra chinensis from North East China / 殷军. 中国医药科技出版社, 2012, p. 74-129
Ko, Robert Kam Ming; Chen, Na; Hua, Y.L. Book chapter

2011 20

(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells
BioFactors, v. 37, (1), January/February 2011, p. 51-57
Lam, Yeung; Ko, Robert K.M. Article
‘Yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes
Chinese Medicine, v. 2, March 2011
Wong, Hoi Shan; Leung, Hoi Yan; Ko, Robert K.M. Article
A Proteomic Approach in Investigating the Hepatoprotective Mechanism of Schisandrin B: Role of Raf Kinase Inhibitor Protein
Journal of proteome research, v. 10, (1), January 2011, p. 299-304
Chen, Yan; Ip, Siu-Po; Ko, Robert K.M.; Poon, Terence C.W.; Ng, Eddy W.Y.; Lai, Paul B.S.; Mao, Qing-Qiu; Xian, Yan-Fang; Che, Chun-Tao Article
Acute treatment with Danshen–Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKC?/mK_ATP pathway in rats
Phytomedicine, v. 18, (11), August 2011, p. 916-925
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Co-treatment with shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats
Rejuvenation Research, v. 14, (1), February 2011, p. 17-23
Chiu, Po Yee; Lam, Yeung; Leung, Hoi Yan; Leong, Pou Kuan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M. Article
Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKC?/mK_ATP pathways in H9c2 cardiomyocytes
Phytomedicine, v. 19, (2), January 2012, p. 99-110
Chiu, Po Yee; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zou, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 383, (6), June 2011, p. 585-591
Pan, Si-Yuan; Dong, Hango; Guo, Bao-Feng; Zhang, Yi; Yu, Zhi-Ling; Fong, Wang-Fun; Han, Yi-Fan; Ko, Robert K.M. Article
Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Yu, Zhi-Ling; Dong, Hang; Xiang, Chun-Jing; Fong, Wang-Fun; Ko, Robert K.M. Article
Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes
Chinese Medicine, v. 2, (3), September 2011, p. 103-108
Lau, David T.W.; Poon, Michel K.T.; Leung, Hoi Yan; Ko, Robert K.M. Article
Long-term treatment with danshen-gegen decoction protects the myocardium against Ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK_ATP pathway in rats
Rejuvenation Research, v. 14, (2), May 2011, p. 173-184
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mK_ATP-mediated pathway in rats
Chinese Medicine, v. 6, February 2011, article number 7
Wong, Sze Man; Chiu, Po Yee; Leung, Hoi Yan; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M. Article
Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
Free Radical Research, v. 45, (8), August 2011, p. 950-958
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Sato, Shinji; Ko, Robert K.M.; Konishi, Tetsuya Article
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes
Free Radical Research, v. 45, (4), 2011, p. 483-495
Leong, Pou Kuan; Chiu, Po Yee; Chen, Na; Leung, Hoi Yan; Ko, Kam Ming Article
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells
Molecular and Cellular Biochemistry, v. 350, (1-2), April 2011, p. 237-250
Chiu, Po Yee; Chen, Na; Leong, Po Kuan; Leung, Hoi Yan; Ko, Robert K.M. Article
Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells
BioFactors, v. 37, (6), November/December 2011, p. 439-446
Lam, Yeung; Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts
Fitoterapia, v. 82, (4), June 2011, p. 682-691
Chiu, Po Yee; Lam, Yeung; Yan, Chung Wai; Ko, Robert K.M. Article
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue
Fitoterapia, v. 82, (3), April 2011, p. 393-400
Lam, Yeung; Yan, Chung Wai; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity
Basic & Clinical Pharmacology & Toxicology, v. 109, (4), October 2011, p. 261-265
Pan, Si-Yuan; Zhang, Yi; Guo, Bao-feng; Han, Yi-Fan; Ko, Robert K.M. Article
Tacrine Treatment at High Dose Suppresses the Recognition Memory in Juvenile and Adult Mice with Attention to Hepatotoxicity
Basic & Clinical Pharmacology & Toxicology, v. 108, (6), June 2011, p. 421-427
Pan, Si-Yuan; Guo, Bao-Feng; Zhang, Yi; Yu, Qing; Yu, Zhi-Ling; Dong, Hang; Ye, Yan; Han, Yi-Fan; Ko, Robert K.M. Article

2010 10

A Red Wine Extract Supplement Protects against Apoptosis and Inhibits Changes in Mitochondrial Permeability and Membrane Potential
Journal of Complementary and Integrative Medicine, v. 7, (1), January 2010
Chen, Na; Chiu, Po Yee; Ko, Robert K.M. Article
Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells
Journal of Ethnopharmacology, v. 128, (1), March 2010, p. 116-122
Chen, Meng-Li; Ip, Siu-Po; Tsai, Sam-Hip; Ko, Robert K.M.; Che, Chun-Tao Article
Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins
Pharmaceutical Biology, v. 48, (5), April 2010, p. 512-517
Siu, A.H.L.; Ko, Robert K.M. Article
Long-Term Dietary Supplementation with a Yang-Invigorating Chinese Herbal Formula Increases Lifespan and Mitigates Age-Associated Declines in Mitochondrial Antioxidant Status and Functional Ability of Various Tissues in Male and Female C57BL/6J Mice
Rejuvenation Research, v. 13, (2-3), May 2010, p. 168-171
Ko, Robert K.M.; Chiu, Po Yee; Leung, Hoi Yan; Siu, A.H.L.; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K.T. Article
Long-Term Treatment with a "Yang-Invigorating" Chinese Herbal Formula, Wu-Zi-Yan-Zong-Wan, Reduces Mortality and Liver Oxidative Damage in Chronic Alcohol-Intoxicated Rats
Rejuvenation Research, v. 13, (4), August 2010, p. 459-467
Chen, Meng-Li; Tsai, Sam-Hip; Ip, Siu-Po; Ko, Robert K.M.; Che, Chun-Tao Article
Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity
Journal of Medicinal Food, v. 13, (2), April 2010, p. 427-438
Leong, Pou Kuan; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M. Article
New perspectives on innovative drug discovery: An overview
Journal of Pharmacy and Pharmaceutical Sciences, v. 13, (3), 2010, p. 450-471
Pan, Si-Yuan; Pan, Shan; Yu, Zhi-Ling; Ma, Dik-Lung; Chen, Si-Bao; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M. Article
Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats
Fitoterapia, v. 81, (8), December 2010, p. 1239-1245
Lam, Yeung; Chiu, Po Yee; Leung, Hoi Yan; Chen, Na; Leong, Pou Kuan; Ko, Robert K.M. Article
Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection are Mediated by Reactive Oxidant Species Production in Rat Hearts
Biological and Pharmaceutical Bulletin, v. 33, (5), May 2010, p. 825-829
Chen, Na; Ko, Robert K.M. Article
Antioxidant and anticarcinogenic potential of sesame lignans
Sesame: The genus Sesamum. Medicinal and Aromatic Plants – Industrial Profiles. / Edited by Dorothea Bedigian. Boca Raton : CRC Press, Taylor & Francis Group, 2010, p. 111-131, Ch. 5
Mak, Duncan H.K.; Chiu, Po Yee; Ko, Robert Kam Ming Book chapter

2009 10

An integrative approach to product development-A skin-care cream
Computers & chemical engineering, v, 33, (5), May 2009, p. 1097-1113
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto Article
Comparison Studies of Tacrine and Bis(7)-Tacrine on the Suppression of Scopolamine-Induced Behavioral Changes and Inhibition of Acetylcholinesterase in Mice
Pharmacology, v. 83, (5), 2009, article number PHA2, p. 294-300
Pan, Si-Yuan; Yu, Zhi-Ling; Xiang, Chun-Jing; Dong, Hang; Fang, Hai-Yan; Ko, Kam-Ming Article
Effect of Extraction Solvent on the Bioactivity of an Herbal Formulation
Industrial and Engineering Chemistry Research, v. 48, (10), May 2009, p. 4852-4857
Chan, Kin N.; Lau, Choi C.; Chow, King Lau; Ko, Robert Kam Ming; Tsim, Karl Wah Keung; Ng, Ka Ming Article
Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity
Journal of ethnopharmacology, v. 124, (2), July 2009, p. 316-320
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Xian, Yan-Fang; Che, Chun-Tao Article
Exposure to oscillating high electrical potential and the associated low frequency magnetic field enhances the hepatoprotective action of schisandrin B in vivo and in vitro
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 23
Ko, Kam Ming; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Leung, Hoi Yan; Chiu, Po Yee Article
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
Nucleic acids research, v. 37, (17), September 2009, p. 5678-5689
Nishida, Hiroshi; Tatewaki, Naoto; Nakajima, Yuki; Magara, Taku; Ko, Kam Ming; Hamamori, Yasuo; Konishi, Tetsuya Article
Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: Effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor
Progress in neuro-psychopharmacology & biological psychiatry, v. 33, (7), October 2009, p. 1211-1216
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Che, Chun-Tao Article
Peony Glycosides Protect Against Corticosterone-Induced Neurotoxicity in PC12 Cells
Cellular and molecular neurobiology, v. 29, (5), July 2009, p. 643-647
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Zhao, Ming; Che, Chun-Tao Article
Protective effect of red wine extract supplement against myocardial ischemia/reperfusion injury in rats: Effects on mitochondrial antioxidant and structural parameters
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 21
Ko, Kam Ming; Chen, Na; Chiu, Po Yee Article
Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation-induced Apoptosis and Associated Changes in the Ca-2+-induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in AML12 Hepatocytes
Phytotherapy research, v. 23, (11), November 2009, p. 1592-1602
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Robert Kam Ming Article

2008 13

A `Yang-invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats
Phytotherapy research, v. 22, (1), January 2008, p. 131-133
Poon, Michel Kwong Tat; Chiu, Po Yee; Leung, Hoi Yan; Sin, Ada Hoi Ling; Ko, Kam Ming Article
Herba Cistanche extract enhances mitochondrial ATP generation in rat hearts and H9C2 cells
Pharmaceutical biology, v. 46, (6), October 2008, p. 428-424
Leung, Hoi Yan; Ko, Kam Ming Article
Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice
BioFactors, v. 34, (4), December 2008, p. 331-342
Ko, Kam Ming; Chen, Na; Leung, Hoi Yan; Leong, Eriol P.K.; Poon, Michel K.T.; Chiu, Po Yee Article
Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis
Rejuvenation Research, v. 11, (6), December 2008, p. 991-1000
Zhang, Guang-Qin; Wang, Hui; Liu, Wen-Tao; Dong, Hang; Fong, Wang-Fun; Tang, Li-Min; Xiong, Yun-Hua; Yu, Zhi-Ling; Ko, Kam-Ming Article
Long-term treatment with a yang-invigorating chinese herbal formula produces generalized tissue protection against oxidative damage in rats
Rejuvenation research, v. 11, (1), February 2008, p. 43-62
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Poon, Michel K.T.; Ko, Kam Ming Article
Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
Biological and Pharmaceutical Bulletin, v. 31, (7), July 2008, p. 1387-1391
Chen, Na; Chiu, Po Yee; Ko, Kam Ming Article
Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats
Biological & pharmaceutical bulletin, v. 31, (4), April 2008, p. 602-605
Chiu, Po Yee; Leung, Hoi Yan; Ko, Kam Ming Article
Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 60, (3), March 2008, p. 399-403
Pan, Si-Yuan; Dong, Hang; Zhao, Xing-Ye; Xiang, Chun-Jing; Fang, Hai-Yan; Fong, Wang-Fun; Yu, Zhi-Ling; Ko, Kam-Ming Article
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes
Life Sciences, v. 82, (21-22), May 2008, p. 1092-1101
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Kam Ming Article
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
Biochemical Engineering Journal, v. 42, (1), October 2008, p. 55-60
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Article
Separation and purification of schisandrin B from Fructus schisandrae
Industrial and Engineering Chemistry Research, v. 47, (12), June 2008, p. 4193-4201
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Article
Development of a skin-care cream containing zinc oxide nanoparticles and an herbal extract
2008 AIChE Annual Meeting, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto Conference paper
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
AIChE Annual Meeting, Conference Proceedings, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008, 2008
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Conference paper

2007 6

Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 59, (12), 2007, DEC, p. 1657-1662
Pan, Si-Yuan; Dong, Hang; Yu, Zhi-Ling; Zhao, Xin-Ye; Xiang, Chun-Jing; Wang, Hui; Fong, Wang-Fun; Ko, Kam-Ming Article
Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration
Planta medica, v. 73, (2), 2007, FEB, p. 134-141
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada H.Y.; Poon, Michel K.T.; Dong, Tina Tingxia; Tsim, Karl Wah Keung; Ko, Kam Ming Article
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs
Chinese Medicine, v. 2, 2007
Ko, Kam Ming; Leung, Hoi Yan Article
Evaluation of acute bis(7)-tacrine treatment on behavioral functions in 17-day-old and 30-day-old mice, with attention to drug toxicity
Pharmacology BIOCHEMISTRY and Behavior, v. 86, (4), 2007, APR, p. 778-783
Pan, Si Yuan; Yu, Zhi Ling; Dong, Hang; Lee, Nelson Tsz Kin; Wang, Hui; Fong, Wang Fun; Han, Yi Fan; Ko, Kam Ming Article
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers
Biological & pharmaceutical bulletin, v. 30, (6), 2007, JUN, p. 1108-1112
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Ko, Kam Ming Article
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts
ACTA PHARMACOLOGICA SINICA, v. 28, (10), 2007, OCT, p. 1559-1565
Chiu, Po-Yee; Leung, Hoi-Yan; Siu, Ada Hoi Ling; Poon, Michel Kwong Tat; Ko, Kam-Ming Article

2006 14

(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes
Molecular and cellular biochemistry, v. 289, (1-2), 2006, SEP, p. 185-191
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Mak, Duncan H.F.; Ko, Kam Ming Article
A characteristic pharmacological action of `Yang-invigorating' Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity
Phytomedicine, v. 13, (9-10), 2006, NOV, p. 636-642
Ko, Kam-Ming; Leon, T.Y.Y.; Mak, Duncan H.F.; Chiu, Po-Yee; Du, Ying; Poon, Michel Kwong Tat Article
A novel experimental model of acute hypertriglyceridemia induced by schisandrin B
European journal of pharmacology, v. 537, (1-3), 2006, MAY 10, p. 200-204
Pan, Si Yuan; Dong, Hang; Han, Yi Fan; Li, Wen Yuan; Zhao, Xing Y.; Ko, Kam Ming Article
Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice
European journal of pharmacology, v. 552, (1-3), 2006, DEC 15, p. 170-175
Pan, Si-Yuan; Yang, Rong; Dong, Hang; Yu, Zhi-ling; Ko, Kam-Ming Article
Biochemical basis of the "Qi-invigorating" action of Schisandra berry (Wu-Wei-Zi) in Chinese medicine
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 34, (2), 2006, p. 171-176
Ko, Kam Ming; Chiu, Po Yee Article
Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats
Biogerontology, v. 7, (4), 2006, AUG, p. 199-210
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Ko, Kam Ming Article
Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes
Phytotherapy research, v. 20, (7), 2006, JUL, p. 561-567
Mak, Duncan Hon Fai; Chiu, Po Yee; Dong, Tina Ting Xia; Tsim, Karl Wah Keung; Ko, Kam Ming Article
Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts
Molecular and cellular biochemistry, v. 288, (1-2), 2006, AUG, p. 135-142
Du, Ying; Ko, Kam Ming Article
Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes
Pharmacology, v. 77, (2), 2006, p. 63-70
Chiu, PY; Leung, HY; Poon, MKT; Mak, DHF; Ko, KM Article
Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17-and 30-day-old mice
Pharmacology BIOCHEMISTRY and Behavior, v. 85, (1), 2006, SEP, p. 50-56
Pan, Si Yuan; Han, Yi Fan; Yu, Zhi Ling; Yang, Rong; Dong, Hang; Ko, Kam Ming Article
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia
ACTA PHARMACOLOGICA SINICA, v. 27, (6), 2006, JUN, p. 673-678
Pan, Si Yuan; Yang, Rong; Han, Yi Fan; Dong, Hang; Feng, Xu Dong; Li, Na; Geng, Wei; Ko, Kam Ming Article
Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats
Planta medica, v. 72, (3), 2006, FEB, p. 222-227
Du, Ying; Ko, Kam Ming Article
Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver
Molecular and cellular biochemistry, v. 293, (1-2), 2006, DEC, p. 87-92
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Lee, Susanna S.T.; Ko, Kam Ming Article
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells
BioFactors, v. 26, (4), 2006, p. 221-230
Chiu, Po Yee; Ko, Kam Ming Article

2005 5

A Yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats
Rejuvenation research, v. 8, (4), 2005, WIN, p. 238-247
Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference
Life sciences, v. 77, (22), 2005, OCT 14, p. 2770-2782
Du, Ying; Ko, Kam Ming Article
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver
Life sciences, v. 77, (23), 2005, OCT 21, p. 2887-2895
Chiu, PY; Mak, DHF; Poon, MKT; Ko, KM Article
Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells
Molecular and cellular biochemistry, v. 276, (1-2), 2005, AUG, p. 227-234
Ko, Kam Ming; Chiu, Po Yee Article
A "Yang-invigorating" Chinese herbal suppository preparation relieves symptoms in patients with Parkinson's disease
New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005, 2005, p. 243-246
Ko, KM; Chan, K.; Shek, L.; Yeung, J.; Chui, SH Conference paper

2004 7

A Yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects
Phytotherapy research, v. 18, (7), 2004, JUL, p. 525-530
Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Ng, Timothy TL; Chung, YK; Lam, BYH; Du, Ying; Ko, KM Article
Comparing an in vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs
Phytotherapy research, v. 18, (2), 2004, FEB, p. 149-153
Beissenhirtz, Moritz K.; Kwan, Roger Cheuk Hung; Ko, Kam Ming; Renneberg, Reinhard; Scheller, Frieder W.; Lisdat, Fred Article
Pharmacological basis of `Yang-invigoration' in Chinese medicine
Trends in pharmacological sciences, v. 25, (1), 2004, JAN, p. 3-6
Ko, Kam Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat Article
Pharmacological basis of `Yin-nourishing' and `Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb
Life sciences, v. 76, (4), 2004, DEC 10, p. 385-395
Siu, Kai Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Du, Ying; Ko, KM Article
Processing control of Chinese herbal products: An ultimate approach for quality assurance
Asia-Pacific Biotech News, v. 8, (23), 2004, p. 1338-1341
Ko, Robert Kam Ming; Ng, Ka Ming Article
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats
Molecular and cellular biochemistry, v. 266, (1-2), 2004, NOV, p. 139-144
Chiu, Po Yee; Ko, Kam Ming Article
Deciphering the Myth of Fructus Schisandrae in Traditional Chinese Medicine: Biochemical Basis of its Qi-invigorating Action
Recent Progress in Medicinal Plants Volume 9: Plant Bioactives in Traditional Medicine / J.N. Govil, V.K. Singh, Rajeev Kr. Sharma. Studium Press LLC, 2005, p. 147-163
Ko, K.M.; Chiu, P.Y. Book chapter

2003 10

Challenges in the globalization of Chinese herbal medicine
Asia-Pacific Biotech News., 7:1287-89
Ko, K.M. Article
East meets west in anti-aging medicine
Annal Asia Anti-aging Med. Assoc., 2004:39-44
Ko, K.M. Article
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice
BioFactors, v. 19, (1-2), 2003, p. 33-42
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming Article
Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins
FREE RADICAL BIOLOGY AND MEDICINE, v. 35, (4), 2003, AUG 15, p. 368-380
Chiu, Po Yee; Tang, Man Ho; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Metformin protects against carbon tetrachlordie hepatootoxicity in mice: Enhancement of mitochondrial glutathione redox status
Journal of pharmacological sciences, v. 93, (4), 2003, DEC, p. 501-504
Poon, Michel Kwong Tat; Chiu, Po Yee; Mak, Duncan Hon Fai; Ko, Kam Ming Article
Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury
BioFactors, v. 19, (1-2), 2003, p. 43-51
Chiu, Po Yee; Ko, Kam Ming Article
Schisandrin B and other Dibenzocyclooctadiene lignans. In: Herbal Medicines: Molecular Basis in Health & Diseases Management
Marcel Dekker: New York, Basel, Hong Kong / 289-314
Ko, K.M. Book
Anti-aging effects of a Chinese medicine preparation on elderly male subjects
2nd Asia Pacific Conferenece and Exhibition on Anti-Aging Medicine, Singapore, p.73, September
Ko, K.M. Conference paper
Antioxidant potential of a Chinese Medicine Preparation in vitro and in vivo/ex vivo
2nd Asia Pacific Conference and Exhibition on Anti-Aging Medicine 2003, Singapore, p.50, September
Ko, K.M.; Mak, Duncan H.F.; Poon, Michel K.T. Conference paper
Biochemical, immunological, hormonal and anti-oxidant effects of a Chinese Herbal Suppository, Vigconic HY28, on Elderly Male Subjects - An anti-aging solution?
Anti-Aging World Conference, Paris, France, p.105
Chui, Siu Hon; Ko, Kam Ming Conference paper

2002 10

Antioxidant and immunomodulatory activities of Chinese tonifying herbs
Pharmaceutical biology, v. 40, (5), 2002, AUG, p. 329-335
Yim, Tze Kin; Ko, Kam Ming Article
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin
Planta medica, v. 68, (11), 2002, NOV, p. 951-956
Chiu, Po Yee; Mak, Duncan Hon Fai; Poon, Michel Kong Tat; Ko, Kam Ming Article
Protection against carbon tetrachloride liver toxicity by enantiomers of schisandrin B associated with differential changes in hepatic glutathione antioxidant system in mice
Pharmaceutical biology, v. 40, (4), 2002, p. 298-301
Ko, Kam Ming; Poon, Michel Kwong Tat; Ip, Siu Po; Wu, Kim Article
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice
Planta medica, v. 68, (3), 2002, MAR, p. 217-220
Pan, Si Yuan; Han, Yi Fan; Carlier, Paul R.; Pang, Yuan Ping; Mak, Duncan Hon Fai; Lam, Brian Yee Hong; Ko, Kam Ming Article
Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
Molecular and cellular biochemistry, v. 238, (1-2), 2002, SEP, p. 181-186
Ko, Kam Ming; Lam, Brian Yee Hong Article
Shengmai San
Shengmai San / Edited by Kam-Ming Ko. Taylor & Francis: London, 2002
Ko, Kam Ming Book
Pharmacological studies on Shengmai San
Shengmai San / Editied by Kam-Ming Ko. London: Taylor & Francis, 2002, p. 16-40
Ko, Kam Ming; Mak, Duncan Hon Fai; Yim, Tsz Kin; Yan, Yong Qing Book chapter
A question of quality
Current Drug Discovery, (MAY), 2002, p. 41-42
Ko, Robert Kam Ming Conference paper
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione antioxidant status and induction of heat shock proteins in mice.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p.77
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming Conference paper
Time-dependent enhancement in mitochondrial glutathione antioxidant and functional status by schisandrin B treatment decrease the susceptibility of rats hearts to ischemia-reperfusion injury.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p. 75
Chiu, Po Yee; Ko, Kam Ming Conference paper

2001 5

Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants
Japanese journal of pharmacology, v. 85, (4), 2001, APR, p. 435-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Yiu, Ho Yan Article
Effects of Fructus Ligustri Lucidi extracts on concanavalin A-stimulated proliferation of isolated murine splenocytes
Pharmaceutical biology, v. 39, (2), 2001, p. 146-151
Yim, Tze Kin; Ko, Kam Ming Article
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver
Cell stress & chaperones, v. 6, (1), 2001, JAN, p. 44-48
Ip, Siu Po; Che, Chun Tao; Kong, Yun Cheung; Ko, Kam Ming Article
Hepatoprotective action of an oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice
Phytotherapy research, v. 15, (7), 2001, NOV, p. 589-592
Yim, Tze Kin; Wu, WK; Pak, WF; Ko, Kam Ming Article
Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts
Molecular and cellular biochemistry, v. 220, (1-2), 2001, APR, p. 141-147
Ko, Kam Ming; Yiu, Ho Yan Article

2000 3

Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice
Molecular and cellular biochemistry, v. 205, (1-2), 2000, FEB, p. 111-114
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming Article
Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented `Dang-Gui Decoction for Enriching Blood', a compound formulation, ex vivo
Phytotherapy research, v. 14, (3), 2000, MAY, p. 195-199
Yim, Tze Kin; Wu, WK; Pak, WF; Mak, Duncan Hon Fai; Liang, SM; Ko, Kam Ming Article
Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity
Molecular and cellular biochemistry, v. 208, (1-2), 2000, MAY, p. 151-155
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming Article

1999 2

Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats
Biochemical pharmacology, v. 57, (1), 1999, JAN 1, p. 77-81
Yim, Tze Kin; Ko, Kam Ming Article
Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status
Molecular and cellular biochemistry, v. 196, (1-2), 1999, JUN, p. 151-156
Yim, Tze Kin; Ko, Kam Ming Article

1998 3

In vivo antioxidant mechanism of `Sheng Mai San', a compound formulation
Pharmaceutical biology, v. 36, (3), 1998, JUL, p. 189-193
Yick, Pak Kin; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming Article
Myocardial protective effect of an anthraquinone-containing extract of Polygonum multiflorum ex vivo
Planta medica, v. 64, (7), 1998, OCT, p. 607-611
Yim, Tze Kin; Wu, WK; Mak, Duncan Hon Fai; Ko, Kam Ming Article
Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice
ACTA PHARMACOLOGICA SINICA, v. 19, (4), 1998, JUL, p. 313-316
Ip, Siu Po; Che, Chun Tao; Ko, Kam Ming Article

1997 4

Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and Schisandrin B treatment
Molecular and cellular biochemistry, v. 175, (1-2), 1997, OCT, p. 225-232
Mak, Duncan Hon Fai; Ko, Kam Ming Article
Antioxidant activities of Polygonum multiflorum Thunb, in vivo and in vitro
Phytotherapy research, v. 11, (1), 1997, FEB, p. 42-44
Ip, Siu Po; Tse, ASM; Poon, Michel Kwong Tat; Ko, Kam Ming; Ma, CY Article
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice
Biochemical pharmacology, v. 54, (2), 1997, JUL 15, p. 317-319
Ip, Siu Po; Ma, Cui Ying; Che, Chun Tao; Ko, Kam Ming Article
Protective effect of a lignan-enriched extract of fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy Research, v. 11, (8), 1997, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article

1996 8

Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats
Molecular and cellular biochemistry, v. 162, (2), 1996, SEP 20, p. 153-158
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats
Pharmacology & toxicology, v. 78, (6), 1996, JUN, p. 413-416
Ip, Siu Po; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo
Molecular and cellular biochemistry, v. 165, (2), 1996, DEC 20, p. 161-165
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo
Phytomedicine, v. 3, (2), 1996, SEP, p. 217-221
Li, Pui Chun; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming Article
Protective effect of a lignan-enriched extract of Fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy research, v. 10, (5), 1996, AUG, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article
Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 24, (3-4), 1996, p. 255-262
Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver
FREE RADICAL BIOLOGY AND MEDICINE, v. 21, (5), 1996, p. 709-712
Ip, Siu Po; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming Article
The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene
Biochemical pharmacology, v. 52, (11), 1996, DEC 13, p. 1687-1693
Ip, Siu Po; Ko, Kam Ming Article

1995 4

Effect of a lignan-enriched fructus Schisandrae extract on hepatic glutathione status in rats: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (2), 1995, APR, p. 134-137
Ko, Kam Ming; Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung Article
Effect of Schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (5), 1995, OCT, p. 398-401
Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming Article
Enhancement of hepatic glutathione regeneration capacity by a lignan-enriched extract of fructus schisandrae in rats
Japanese journal of pharmacology, v. 69, (4), 1995, DEC, p. 439-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article
Schisandra Chinensis-derived antioxidant activities in 'Sheng Mai San', a compound formulation, in vivo and in vitro
Phytotherapy research, v. 9, (3), 1995, MAY, p. 203-206
Ko, Kam Ming; Yick, Pak Kin; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung Article

1994 1

Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids
Molecular and Cellular Biochemistry, v. 141, (1), p. 65-70
Ko, Kam Ming; Yick, Pak Kin; Poon, Michael K.T.; Ip, Siu Po Article

1993 1

Impaired hepatic antioxidant status in carbon tetrachloride intoxicated rats: An in vivo model for screening herbal extracts with antioxidant activities
Fitoterapia, v. 64, (6), 1993, p. 539-544
Ko, Kam Ming; Yick, Pak Kin; Chiu, Tillie; Hui, T.Y.; Cheng, Christopher Hon Ki; Kong, Yun Cheung Article

1990 1

Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol
Biochemical Pharmacology, v. 40, Issue 4, 15 August 1990, Pages 803-809
Ko, Kam Ming; Godin, David V. Article


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Article 3

Antioxidant and Immunopotentiating Effects of Cordyceps Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models
Chinese Medicine, v. 12, (1), Mach 2021, p. 1-9
Leung, Hoi Yan; Yan, Choly Tat Ming; Ko, Kam Ming
Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice
Evidence-based Complementary and Alternative Medicine, v. 2021, February 2021, article number 8858962
Wang, Xiao-Yan; Song, Xue-Lan; Zhang, Yi; Luo, Gan; Tai, Hai-Chuan; Lin, Zhao-Heng; Zhu, Pei-Li; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Pan, Si-Yuan; Tang, Jin-Fa; Ko, Kam Ming
The Use Of Chinese Yang/Qi-Invigorating Tonic Botanical Drugs/Herbal Formulations In Ameliorating Chronic Kidney Disease By Enhancing Mitochondrial Function
Frontiers in Pharmacology, v. 12, 24 June 2021, article number 622498
Tian, Jiayi; Huang, Yuqi; Wu, Tong; Huang, Hsien-Da; Ko, Kam Ming; Zhu, Bao Ting; Chen, Jihang


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Article 3

A unifying theory of aging between modern medicine and traditional Chinese medicine
Chinese Medicine, v. 11, (2), June 2020, p. 105-112
Cheung, Kai Chit; Leung, Hoi Yan; Ko, Robert Kam Ming
Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma
Molecules, v. 25, (18), September 2020, article number 4051
Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Leong, Pou Kuan; Yan, Choly Tat Ming; Ko, Kam Ming
Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways
FASEB Journal, v. 34, (3), March 2020, p. 4311-4328
Yu, Xiaodan; Xu, Li Miranda; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Duan, Ran; Dong Ting Xia; Ko, Kam Ming; Tsim, Karl Wah Keung


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Article 5

48Biochemical Mechanisms of the Anti-Obesity Effect of a Triterpenoid-Enriched Extract of Cynomorium Songaricum in Mice With High-Fat-Diet-Induced Obesity
Phytomedicine, v. 73, July 2020, article number 153038
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Wong, Hoi Shan; Ko, Robert Kam Ming
A Chinese Herbal Formulation, Xiao-Er-An-Shen Decoction, Attenuates Tourette Syndrome, Possibly by Reversing Abnormal Changes in Neurotransmitter Levels and Enhancing Antioxidant Status in Mouse Brain
Frontiers in Pharmacology, v. 10, July 2019, article number 812
Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Li, Zhonggui; Qiu, Jingyu; Ko, Kam Ming; Chen, Jianping
Pharmacological Investigation of “Meridian Tropism” in Three “Shen” Chinese Herbs
Chinese Medicine, v. 10, (4), December 2019, p. 121-135
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming
Yang/Qi-invigorating herbs for the prevention and/or treatment of diabetic complications
Longhua Chinese Medicine, v. 2, March 2019, article number 4
Leong, Pou Kuan; Ko, Robert Kam Ming
基于脂质代谢组学评价五味子素B诱导的急性高甘油三酯血症小鼠模型
中国药理学通报=Chinese Pharmacological Bulletin, v. 35, (6), 2019, p. 833-839
王晓艳; 储着胜; 张辉; 张书琦; 潘思源; 唐进法; 高锦明

Conference paper 1

Corylin induces bone differentiation and metabolic profiling: illustration by using cultured osteoblasts and bone micromass
15th International Postgraduate Symposium on Chinese Medicine, IPSCM 2019 第15届国际研究生中医药研讨会, Hong Kong, 15-16 August 2019
Yu, Xiaodan; Xu, Li; Yao, Ping; Kwan, Kin Leung; Liu, Yongxiang; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung


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Article 2

Differences in the mechanisms by which Yang-invigorating and Qi-invigorating Chinese tonifying herbs stimulate mitochondrial ATP generation capacity
Chinese Medicine, v. 9, (2), 2018, p. 63-74
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming
Shengmai San: a modern medicine perspective on its remedial effects on Qi and Yin deficiency syndrome in Chinese medicine
Longhua Chinese Medicine, v. 1, 20 September 2018, article number 13
Leong, Pou Kuan; Ko, Robert Kam Ming

Book chapter 1

Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases
Natural Products and Drug Discovery: An Integrated Approach / Edited by: Subhash C. Mandal, Vivekananda Mandal and Tetsuya Konishi. Elsevier, 2018, p. 73-104, Ch. 4
Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming

Conference paper 2

Corylin induced the differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures
The 6th International Symposium on Edible & Medical Plant Resources and the Bioactive Ingredients, ISEPR2018, Nanjing, China, 14-17 October 2018
Yu, Xiaodan; Xu, Li; Yao, Ping; Dai, Kun; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung
Stimulatory effects of corylin on differentiation, mineralization and metabolic activity in rat osteoblasts and micromass cultures
International Conference of the Modernization of Chinese Medicine & Health Products (ICMCM) 2018: Inheritance and Innovation - In Commemoration of the 500th Anniversary of the Birth of Li Shizhen, Hong Kong, Hong Kong, 16-17 August 2018
Yu, Xiaodan; Xu, Li; Yao, Ping; Dong, Tingxia; Ko, Kam Ming; Tsim, Karl Wah Keung


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Article 4

Acute Pre-/Post-Treatment with 8th Day SOD-Like Supreme (a Free Radical Scavenging Health Product) Protects against Oxidant-Induced Injury in Cultured Cardiomyocytes and Hepatocytes In Vitro as Well as in Mouse Myocardium and Liver In Vivo
Antioxidants, v. 6, (2), June 2017, article number 28
Leong, Pou Kuan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Chan, Lincoln; Ko, Kam Ming
Biochemical Mechanism Underlying Hypertriglyceridemia and Hepatic Steatosis/Hepatomegaly Induced by Acute Schisandrin B Treatment in Mice
Lipids in Health and Disease, v. 16, (1), January 2017, p. 1-15
Zhang, Yi; Zhao, Jing; Zhou, Shufeng; Yu, Zhiling; Wang, Xiaoyan; Zhu, Peili; Chu, Zhusheng; Pan, Siyuan; Xie, Ming; Ko, Kamming
Inter-organ relationships among gut, lung and skin beyond the pathogenesis of allergies: Relevance to the Zang-Fu Theory in Chinese medicine
Chinese Medicine, v. 8, (3), 2017, article number 78205, p. 73-81
Leung, Hiu Yu Cherie; Leong, Pou Kuan; Chen, Jihang; Ko, Robert Kam Ming
Ursolic Acid Induces Mitochondrial Biogenesis Through the Activation of AMPK and PGC-1 in C2C12 myotubes: A possible Mechanism Underlying its Beneficial Effect on Exercise Endurance
Food and Function, v. 8, (7), 2017, p. 2425-2436
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wingman; Ko, Robert K M


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Article 7

A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration
PLoS One, v. 11, (3), March 2016, article number e0149663
Zhang, Liyun; Xiang, Lue; Liu, Yiwen; Venkatraman, Prahatha; Chong, Leelyn; Cho, Jin; Bonilla, Sylvia; Jin, Zi-Bing; Pang, Chi Pui; Ko, Robert K.M.; Ma, Ping; Zhang, Mingzhi; Leung, Yuk Fai
An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents
Chinese Medicine, v. 7, December 2016, p. 153-165
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Jihang; Zhu, Huawei; Ning, Jialing; Yang, Yiting; Ma, Chung Wah; Ko, Robert Kam Ming
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response
PLoS ONE, v. 11, (5), May 2016, article number e0155879
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Ko, Kam Ming
Induction of the Glutathione Antioxidant Response/Glutathione Redox Cycling by Nutraceuticals: Mechanism of Protection against Oxidant-induced Cell Death
Current Trends in Nutraceuticals, v. 1, (1-2), March 2016, p. 1-9
Leong, Pou Kuan; Ko, Robert Kam Ming
Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease
Oxidative Medicine and Cellular Longevity, v. 2016, 2016, article number 6171658
Leong, Pou Kuan; Ko, Kam Ming
Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective
Chinese Medicine, v. 7, (3), August 2016
Chung, Yin Kwan; Chen, Jihang; Ko, Robert Kam Ming
β-Sitosterol increases mitochondrial electron transport by fluidizing mitochondrial membranes and enhances mitochondrial responsiveness to increasing energy demand by the induction of uncoupling in C2C12 myotubes
Journal of Functional Foods, v. 23, May 2016, p. 253-260
Wong, Hoi Shan; Leong, Pou Kuan; Chen, Jihang; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.


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Article 15

A cistanches herba fraction/ β -sitosterol causes a redox-sensitive induction of mitochondrial uncoupling and activation of adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 in C2C12 myotubes: A possible mechanism underlying the weight reduction effect
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 142059
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming
A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice
Lipids in Health and Disease, v. 14, (1), August 2015, article number 97
Chu, Zhusheng; Yu, Zhiling; Pan, Siyuan; Jia, Zhanhong; Wang, Xiaoyan; Zhang, Yi; Zhu, Peili; Wang, Xiujuan; Ko, Kamming
A traditional Chinese medicine approach in treating depression by promoting liver Qi circulation: A western medicine perspective
Chinese Medicine, v. 6, (4), November 2015, p. 187-195
So, Raphaella Wai Lam; Wong, Hoi Shan; Ko, Robert K.M.
Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice
Drug Design, Development and Therapy, v. 9, February 2015, p. 923-935
Zhu, Pei-Li; Pan, Si-Yuan; Zhou, Shu-Feng; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming
Evaluation of a topical herbal agent for the promotion of bone healing
Evidence-based Complementary and Alternative Medicine, v. 2015, February 2015, article number 905270
Siu, Wingsum; Ko, Chunhay; Lam, Ka Wing; Wat, Elaine C.L.; Shum, Waiting; Lau, Clara; Ko, Kam Ming; Hung, Leung Kim; Lau, David Tai Wai; Leung, Pingchung
Hawthorn Nectar Enhances Gastrointestinal Motility as Well as Stimulates Intestinal Amylase and Lipase Activities in Mice
Chinese Medicine, v. 6, September 2015, article number 59435, p. 159-168
Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Poukuan; Leung, Hoiyan; Chan, Wingman; Wong, Hoi Shan; Ko, Robert K.M.
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan
Lily bulb nectar produces expectorant and anti-tussive activities, and suppresses cigarette smoke-induced inflammatory response in the respiratory tract in mice
Chinese Medicine, v. 6, June 2015, article number 56861, p. 136-146
Wong, Hoi Shan; Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.
Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells
Food and Function, v. 6, (2), February 2015, p. 549-557
Chen, Jihang; Wong, Hoi Shan; Ko, Kam Ming
New perspectives on dietary-derived treatments and food safety – Antinomy in a new era
Critical Reviews in Food Science and Nutrition, v. 55, (13), November 2015, p. 1836-1859
Pan, Si-Yuan; Gao, Si-Hua; Lin, Rui-Chao; Zhou, Shu-Feng; Dong, Hong-Guan; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M.
Schisandrin B Ameliorates ICV-Infused Amyloid beta Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-kappa B/MAPK and Up-Regulating HSP/Beclin Expression
PLoS One, v. 10, (11), November 2015, article number e0142483
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Arumugam, Somasundaram; Mizuno, Makoto; Nawa, Hiroyuki; Suzuki, Kenji; Ko, Robert K.M.; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya
Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo
BioFactors, v. 41, (5), September 2015, p. 314-323
Leong, Pou-Kuan; Ko, Kam-Ming
Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity
Drug Design, Development and Therapy, v. 9, April 2015, p. 2001-2027
Zhang, Yi; Zhou, Zhiwei; Jin, Hua; Hu, Chengbin; He, Zhixu; Yu, Zhiling; Ko, Robert K.M.; Yang, Tianxin; Zhang, Xueji; Pan, Siyuan; Zhou, Shufeng
Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling
PLoS ONE, v. 10, (3), March 2015, article number e0119214
Thandavarayan, Rajarajan A.; Giridharan, Vijayasree V.; Arumugam, Somasundaram; Suzuki, Kenji; Ko, Kam Ming; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya
Yang/Qi invigoration: An herbal therapy for chronic fatigue syndrome with yang deficiency?
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 945901
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Ko, Kam Ming

Book 1

Schisandra Chinensis: An Herb of North Eastern China Origin
Schisandra Chinensis: An Herb of North Eastern China Origin / by Kam-Ming Ko , Jun Yin and Chuixin Qin. Singapore: World Scientific Publishing, 2015.
Ko, Kam Ming; Yin, Jun; Qin, Chuixin

Conference paper 1

An investigation of anti-inflammatory activities produced by schisandrin A and schisandrin B in vitro and in vivo
12th World Congress on Inflammation, Boston, MA, USA, 8-12 August 2015
Leong, Pou Kuan; Ko, Robert K.M.


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Article 15

Acute and Long-term Treatment with an Herbal Formula V-Vital Capsule Increase Exercise Endurance Capacity in Weight-loaded Swimming Mice
Chinese Medicine, v. 5, (3), September 2014, p. 153-164
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Ji Hang; Wong, Hoi Shan; Ma, Chung Wah; Zou, Shi Yu; Ko, Robert K.M.
An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 9, July 2014, p. 211-224
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Ko, Robert Kam Ming
An ursolic acid-enriched extract of Cynomorium songaricum protects against carbon tetrachloride hepatotoxicity and gentamicin nephrotoxicity in rats possibly through a mitochondrial pathway: A comparison with ursolic acid
Journal of Functional Foods, v. 7, (1), 2014, p. 330-341
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Chen, Na; Ko, Kam Ming
Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 10, September 2014, p. 292-304
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M.
Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet
Lipids in Health and Disease, v. 13, (1), March 2014, article number 46
Sun, Nan; Pan, Si-Yuan; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Zhou, Shu-Feng; Ko, Robert K M
Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 525340
Pan, Si-Yuan; Litscher, Gerhard; Gao, Si-Hua; Zhou, Shu-Feng; Yu, Zhi-Ling; Chen, Hou-Qi; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ko, Kam-Ming
Long-term Treatment with an Herbal Formula MCC Ameliorates Obesity-associated Metabolic Dysfunction in High Fat Diet-induced Obese Mice: a Comparative Study among MCC and Various Combinations of its Constituents
Chinese Medicine, v. 5, (1), March 2014, article number 44280, p. 34-46
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Ma, Chung Wah; Yang, Yi Ting; Ko, Robert K.M.
New insights into the chemical and biochemical basis of the "yang-invigorating" action of chinese yang-tonic herbs
Evidence-based Complementary and Alternative Medicine, v. 2014, December 2014, article number 856273
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming
Quality Assurance of Chinese Herbal Medicines: Procedure for Multiple-Herb Extraction
AIChE journal, v. 60, (12), December 2014, p. 4014-4026
Lau, Yeuk Tin; Ng, Ka Ming; Chen, Na; Lau, David T.W.; Ko, Robert K.M.; Leung, Ping Chung; Wibowo, Christianto
Schisandrin B enhances glutathione redox cycling and protects against β-amyloid-induced apoptosis in human neuroblastoma SH-SY5Y cells: A comparative study of various phytochemicals
The Open Nutraceuticals Journal, v. 7, (1), December 2014 , p. 49-57
Leong, Pou Kuan; Lam,Yeung; Chen, Na; Ko, Kam Ming
Supplementation with the Extract of Schisandrae Fructus Pulp, Seed, or Their Combination Influences the Metabolism of Lipids and Glucose in Mice Fed with Normal and Hypercholesterolemic Diet
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 472638
Wang, Xiao-Yan; Yu, Zhi-Ling; Pan, Si-Yuan; Zhang, Yi; Sun, Nan; Zhu, Pei-Li; Jia, Zhan-Hong; Zhou, Shu-Feng; Ko, Kam-Ming
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
Drug Design, Development and Therapy, v. 8, September 2014, p. 1429-1439
Zhang, Yi; Pan, Si-Yuan; Zhou, Shu-Feng; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming
Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells
Molecules, v. 19, January 2014, p. 1576-1591
Chen, Jihang; Wong, Hoi Shan; Ko, Robert Kam Ming
β-Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts
PTR. Phytotherapy research, v. 28, (7), July 2014, p. 999-1006
Wong, Hoi Shan; Chen, Na; Leong, Pou Kuan; Ko, Robert Kam Ming
β-Sitosterol Protects against Carbon Tetrachloride Hepatotoxicity but not Gentamicin Nephrotoxicity in Rats via the Induction of Mitochondrial Glutathione Redox Cycling
Molecules, v. 19, (11), October 2014, p. 17649-17662
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming

Book chapter 1

Pharmacological profile of dibenzocyclooctadiene lignans and other active ingredients in Schisadrae Fructus
Schisandra Chinensis: An Herb of North Eastern China Origin / By Kam-Ming Ko, Jun Yin, Chuixin Qin. World Scientific, 2014, p. 97-138, Ch. 4
Ko, Robert K.M.; Chen, Na; Leong, Pou Kuan; Ma, Chung Wah

Conference paper 1

Schisandrin B suppresses the lipopolysaccharide/ATP-induced Inflammasome Activation and Cytotoxicity in Isolated Mouse Peritoneal Macrophages and Cultured RAW264.7 Macrophages via Eliciting Nrf2-driven Antioxidant Response
The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, Hong Kong, 15-16 November 2014
Leong, Pou Kuan; Ko, Kam Ming


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Article 7

A Novel Mouse Model of Combined Hyperlipidemia Associated With Steatosis and Liver Injury by a Single-Dose Intragastric Administration of Schisandrin B/Cholesterol/Bile Salts Mixture
Journal of Pharmacological Sciences, v. 123, (2), 2013, p. 110-119
Pan, Si-Yuan; Jia, Zhan-Hong; Zhang, Yi; Yu, Qing; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Yu, Zhi-Ling; Ko, Robert K.M.
Caspase-3-Dependent Apoptosis of Citreamicin ε-Induced HeLa Cells Is Associated with Reactive Oxygen Species Generation
Chemical Research in Toxicology, v. 26, (7), July 2013, p. 1055-1063
Liu, Lingli; He, Lisheng; Xu, Sharon Ying; Han, Zhuang; Li, Yongxin; Zhong, Jialiang; Guo, Xianrong; Zhang, Xixiang; Ko, Robert K.M.; Qian, Peiyuan
Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes
Pharmaceutical Biology, v. 51, (1), 2013, p. 64-73
Wong, Hoi Shan; Ko, Robert K.M.
Long-Term Treatment with an Herbal Formula MCC Reduces the Weight Gain in High Fat Diet-Induced Obese Mice
Chinese Medicine, v. 4, (3), September 2013, article number 36112, p. 63-71
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Ma, Chung Wa; Yang, Yiting; Ko, Robert K.M.
New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics
Evidence-based Complementary and Alternative Medicine, v. 2013, 2013, article number 627375
Pan, Si-Yuan; Zhou, Shu-Feng; Gao, Si-Hua; Yu, Zhi-Ling; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ma, Dik-Lung; Han, Yi-Fan; Fong, Wang-Fun; Ko, Robert K.M.
Schisandrin B enhances hepatic/myocardial glutathione regeneration capacity and protects against oxidant injury in rat livers and hearts
The Open Nutraceuticals Journal, v. 6, (1), 2013, p. 124-128
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling
Evidence-Based Complementary and Alternative Medicine, v. 2013, March 2013, article number 924128
Chen, Jihang; Ko, Robert K.M.


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Article 14

"Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situ and Rat Hearts ex Vivo
Chinese Medicine, v. 3, (2), June 2012, p. 101-105
Wong, Hoi Shan; Cheung, Weng Fat; Tang, Wai Ling; Ko, Robert K.M.
A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs
Chinese Medicine, v. 3, (1), March 2012, article number 18126
Lam, Yeung; Wong, Hoi Shan; Chen, Jihang; Ko, Robert K.M.
Beneficial effect of (-)Schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells
BioFactors, v. 38, (3), May/June 2012, p. 219-225
Lam, Yeung; Ko, Robert K.M.
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes
Cell Biology International, v. 36, (3), March 2012, p. 321-326
Leong, Pou Kuan; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes
Indian Journal of Pharmacology, v. 44, (2), March 2012, p. 204-209
Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity
Lipids in Health and Disease, v. 11, September 2012, article number 120
Pan, Si-Yuan; Yu, Qing; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Yu, Zhi-Ling; Ko, Robert K.M.
Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
Journal of Complementary and Integrative Medicine, v. 9, (1), November 2012
Leung, Hoi Yan; Ko, Robert K.M.
Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases
Clinical and Experimental Pharmacology & Physiology, v. 39, (3), March 2012, p. 256-264
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity
Journal of Medicinal Food, v. 15, (7), June 2012, p. 629-638
Lam, Yeung; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
New Perspectives on Complementary and Alternative Medicine: An Overview and Alternative Therapy
Alternative Therapies in Health and Medicine, v. 18, (4), July 2012, p. 20-36
Pan, Si-Yuan; Gao, Si-Hua; Zhou, Shu-Feng; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M.
Product Design: A Nanomized Nutraceutical with Enhanced Bioactivity and Bioavailability
Industrial & Engineering Chemistry Research, v. 51, (21), May 2012, p. 7320-7326
Lau, Yeuk Tin; Chen, Na; Ko, Robert K.M.; Ng, Ka Ming
Prooxidant-Induced Glutathione Antioxidant Response in Vitro and in Vivo: A Comparative Study between Schisandrin B and Curcumin
Biological and Pharmaceutical Bulletin, v. 35, (4), April 2012, p. 464-472
Leong, Pou Kuan; Chiu, Po Yee; Ko, Robert K.M.
Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases
Oxidative Medicine and Cellular Longevity, v. 2012, March 2012, article number 250825
Lam, Yeung; Ko, Robert K.M.
Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice
Free Radical Research, v. 46, (1), January 2012, p. 50-60
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Bhilwade, Hari N.; Ko, Robert K.M.; Watanabe, Kenichi; Konishi, Tetsuya

Book chapter 1

五味子及其成分的药理毒理研究
东北道地药材-五味子 - Schisandra chinensis from North East China / 殷军. 中国医药科技出版社, 2012, p. 74-129
Ko, Robert Kam Ming; Chen, Na; Hua, Y.L.


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Article 20

(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells
BioFactors, v. 37, (1), January/February 2011, p. 51-57
Lam, Yeung; Ko, Robert K.M.
‘Yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes
Chinese Medicine, v. 2, March 2011
Wong, Hoi Shan; Leung, Hoi Yan; Ko, Robert K.M.
A Proteomic Approach in Investigating the Hepatoprotective Mechanism of Schisandrin B: Role of Raf Kinase Inhibitor Protein
Journal of proteome research, v. 10, (1), January 2011, p. 299-304
Chen, Yan; Ip, Siu-Po; Ko, Robert K.M.; Poon, Terence C.W.; Ng, Eddy W.Y.; Lai, Paul B.S.; Mao, Qing-Qiu; Xian, Yan-Fang; Che, Chun-Tao
Acute treatment with Danshen–Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKC?/mK_ATP pathway in rats
Phytomedicine, v. 18, (11), August 2011, p. 916-925
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
Co-treatment with shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats
Rejuvenation Research, v. 14, (1), February 2011, p. 17-23
Chiu, Po Yee; Lam, Yeung; Leung, Hoi Yan; Leong, Pou Kuan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M.
Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKC?/mK_ATP pathways in H9c2 cardiomyocytes
Phytomedicine, v. 19, (2), January 2012, p. 99-110
Chiu, Po Yee; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zou, Zhong; Lam, Yeung; Ko, Robert K.M.
Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 383, (6), June 2011, p. 585-591
Pan, Si-Yuan; Dong, Hango; Guo, Bao-Feng; Zhang, Yi; Yu, Zhi-Ling; Fong, Wang-Fun; Han, Yi-Fan; Ko, Robert K.M.
Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Yu, Zhi-Ling; Dong, Hang; Xiang, Chun-Jing; Fong, Wang-Fun; Ko, Robert K.M.
Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes
Chinese Medicine, v. 2, (3), September 2011, p. 103-108
Lau, David T.W.; Poon, Michel K.T.; Leung, Hoi Yan; Ko, Robert K.M.
Long-term treatment with danshen-gegen decoction protects the myocardium against Ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK_ATP pathway in rats
Rejuvenation Research, v. 14, (2), May 2011, p. 173-184
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mK_ATP-mediated pathway in rats
Chinese Medicine, v. 6, February 2011, article number 7
Wong, Sze Man; Chiu, Po Yee; Leung, Hoi Yan; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M.
New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M.
Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
Free Radical Research, v. 45, (8), August 2011, p. 950-958
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Sato, Shinji; Ko, Robert K.M.; Konishi, Tetsuya
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes
Free Radical Research, v. 45, (4), 2011, p. 483-495
Leong, Pou Kuan; Chiu, Po Yee; Chen, Na; Leung, Hoi Yan; Ko, Kam Ming
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells
Molecular and Cellular Biochemistry, v. 350, (1-2), April 2011, p. 237-250
Chiu, Po Yee; Chen, Na; Leong, Po Kuan; Leung, Hoi Yan; Ko, Robert K.M.
Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells
BioFactors, v. 37, (6), November/December 2011, p. 439-446
Lam, Yeung; Leong, Pou Kuan; Chen, Na; Ko, Robert K.M.
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts
Fitoterapia, v. 82, (4), June 2011, p. 682-691
Chiu, Po Yee; Lam, Yeung; Yan, Chung Wai; Ko, Robert K.M.
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue
Fitoterapia, v. 82, (3), April 2011, p. 393-400
Lam, Yeung; Yan, Chung Wai; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M.
Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity
Basic & Clinical Pharmacology & Toxicology, v. 109, (4), October 2011, p. 261-265
Pan, Si-Yuan; Zhang, Yi; Guo, Bao-feng; Han, Yi-Fan; Ko, Robert K.M.
Tacrine Treatment at High Dose Suppresses the Recognition Memory in Juvenile and Adult Mice with Attention to Hepatotoxicity
Basic & Clinical Pharmacology & Toxicology, v. 108, (6), June 2011, p. 421-427
Pan, Si-Yuan; Guo, Bao-Feng; Zhang, Yi; Yu, Qing; Yu, Zhi-Ling; Dong, Hang; Ye, Yan; Han, Yi-Fan; Ko, Robert K.M.


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Article 9

A Red Wine Extract Supplement Protects against Apoptosis and Inhibits Changes in Mitochondrial Permeability and Membrane Potential
Journal of Complementary and Integrative Medicine, v. 7, (1), January 2010
Chen, Na; Chiu, Po Yee; Ko, Robert K.M.
Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells
Journal of Ethnopharmacology, v. 128, (1), March 2010, p. 116-122
Chen, Meng-Li; Ip, Siu-Po; Tsai, Sam-Hip; Ko, Robert K.M.; Che, Chun-Tao
Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins
Pharmaceutical Biology, v. 48, (5), April 2010, p. 512-517
Siu, A.H.L.; Ko, Robert K.M.
Long-Term Dietary Supplementation with a Yang-Invigorating Chinese Herbal Formula Increases Lifespan and Mitigates Age-Associated Declines in Mitochondrial Antioxidant Status and Functional Ability of Various Tissues in Male and Female C57BL/6J Mice
Rejuvenation Research, v. 13, (2-3), May 2010, p. 168-171
Ko, Robert K.M.; Chiu, Po Yee; Leung, Hoi Yan; Siu, A.H.L.; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K.T.
Long-Term Treatment with a "Yang-Invigorating" Chinese Herbal Formula, Wu-Zi-Yan-Zong-Wan, Reduces Mortality and Liver Oxidative Damage in Chronic Alcohol-Intoxicated Rats
Rejuvenation Research, v. 13, (4), August 2010, p. 459-467
Chen, Meng-Li; Tsai, Sam-Hip; Ip, Siu-Po; Ko, Robert K.M.; Che, Chun-Tao
Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity
Journal of Medicinal Food, v. 13, (2), April 2010, p. 427-438
Leong, Pou Kuan; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M.
New perspectives on innovative drug discovery: An overview
Journal of Pharmacy and Pharmaceutical Sciences, v. 13, (3), 2010, p. 450-471
Pan, Si-Yuan; Pan, Shan; Yu, Zhi-Ling; Ma, Dik-Lung; Chen, Si-Bao; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M.
Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats
Fitoterapia, v. 81, (8), December 2010, p. 1239-1245
Lam, Yeung; Chiu, Po Yee; Leung, Hoi Yan; Chen, Na; Leong, Pou Kuan; Ko, Robert K.M.
Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection are Mediated by Reactive Oxidant Species Production in Rat Hearts
Biological and Pharmaceutical Bulletin, v. 33, (5), May 2010, p. 825-829
Chen, Na; Ko, Robert K.M.

Book chapter 1

Antioxidant and anticarcinogenic potential of sesame lignans
Sesame: The genus Sesamum. Medicinal and Aromatic Plants – Industrial Profiles. / Edited by Dorothea Bedigian. Boca Raton : CRC Press, Taylor & Francis Group, 2010, p. 111-131, Ch. 5
Mak, Duncan H.K.; Chiu, Po Yee; Ko, Robert Kam Ming


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Article 10

An integrative approach to product development-A skin-care cream
Computers & chemical engineering, v, 33, (5), May 2009, p. 1097-1113
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto
Comparison Studies of Tacrine and Bis(7)-Tacrine on the Suppression of Scopolamine-Induced Behavioral Changes and Inhibition of Acetylcholinesterase in Mice
Pharmacology, v. 83, (5), 2009, article number PHA2, p. 294-300
Pan, Si-Yuan; Yu, Zhi-Ling; Xiang, Chun-Jing; Dong, Hang; Fang, Hai-Yan; Ko, Kam-Ming
Effect of Extraction Solvent on the Bioactivity of an Herbal Formulation
Industrial and Engineering Chemistry Research, v. 48, (10), May 2009, p. 4852-4857
Chan, Kin N.; Lau, Choi C.; Chow, King Lau; Ko, Robert Kam Ming; Tsim, Karl Wah Keung; Ng, Ka Ming
Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity
Journal of ethnopharmacology, v. 124, (2), July 2009, p. 316-320
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Xian, Yan-Fang; Che, Chun-Tao
Exposure to oscillating high electrical potential and the associated low frequency magnetic field enhances the hepatoprotective action of schisandrin B in vivo and in vitro
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 23
Ko, Kam Ming; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Leung, Hoi Yan; Chiu, Po Yee
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
Nucleic acids research, v. 37, (17), September 2009, p. 5678-5689
Nishida, Hiroshi; Tatewaki, Naoto; Nakajima, Yuki; Magara, Taku; Ko, Kam Ming; Hamamori, Yasuo; Konishi, Tetsuya
Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: Effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor
Progress in neuro-psychopharmacology & biological psychiatry, v. 33, (7), October 2009, p. 1211-1216
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Che, Chun-Tao
Peony Glycosides Protect Against Corticosterone-Induced Neurotoxicity in PC12 Cells
Cellular and molecular neurobiology, v. 29, (5), July 2009, p. 643-647
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Zhao, Ming; Che, Chun-Tao
Protective effect of red wine extract supplement against myocardial ischemia/reperfusion injury in rats: Effects on mitochondrial antioxidant and structural parameters
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 21
Ko, Kam Ming; Chen, Na; Chiu, Po Yee
Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation-induced Apoptosis and Associated Changes in the Ca-2+-induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in AML12 Hepatocytes
Phytotherapy research, v. 23, (11), November 2009, p. 1592-1602
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Robert Kam Ming


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Article 11

A `Yang-invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats
Phytotherapy research, v. 22, (1), January 2008, p. 131-133
Poon, Michel Kwong Tat; Chiu, Po Yee; Leung, Hoi Yan; Sin, Ada Hoi Ling; Ko, Kam Ming
Herba Cistanche extract enhances mitochondrial ATP generation in rat hearts and H9C2 cells
Pharmaceutical biology, v. 46, (6), October 2008, p. 428-424
Leung, Hoi Yan; Ko, Kam Ming
Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice
BioFactors, v. 34, (4), December 2008, p. 331-342
Ko, Kam Ming; Chen, Na; Leung, Hoi Yan; Leong, Eriol P.K.; Poon, Michel K.T.; Chiu, Po Yee
Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis
Rejuvenation Research, v. 11, (6), December 2008, p. 991-1000
Zhang, Guang-Qin; Wang, Hui; Liu, Wen-Tao; Dong, Hang; Fong, Wang-Fun; Tang, Li-Min; Xiong, Yun-Hua; Yu, Zhi-Ling; Ko, Kam-Ming
Long-term treatment with a yang-invigorating chinese herbal formula produces generalized tissue protection against oxidative damage in rats
Rejuvenation research, v. 11, (1), February 2008, p. 43-62
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Poon, Michel K.T.; Ko, Kam Ming
Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
Biological and Pharmaceutical Bulletin, v. 31, (7), July 2008, p. 1387-1391
Chen, Na; Chiu, Po Yee; Ko, Kam Ming
Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats
Biological & pharmaceutical bulletin, v. 31, (4), April 2008, p. 602-605
Chiu, Po Yee; Leung, Hoi Yan; Ko, Kam Ming
Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 60, (3), March 2008, p. 399-403
Pan, Si-Yuan; Dong, Hang; Zhao, Xing-Ye; Xiang, Chun-Jing; Fang, Hai-Yan; Fong, Wang-Fun; Yu, Zhi-Ling; Ko, Kam-Ming
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes
Life Sciences, v. 82, (21-22), May 2008, p. 1092-1101
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Kam Ming
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
Biochemical Engineering Journal, v. 42, (1), October 2008, p. 55-60
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming
Separation and purification of schisandrin B from Fructus schisandrae
Industrial and Engineering Chemistry Research, v. 47, (12), June 2008, p. 4193-4201
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming

Conference paper 2

Development of a skin-care cream containing zinc oxide nanoparticles and an herbal extract
2008 AIChE Annual Meeting, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
AIChE Annual Meeting, Conference Proceedings, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008, 2008
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming


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Article 6

Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 59, (12), 2007, DEC, p. 1657-1662
Pan, Si-Yuan; Dong, Hang; Yu, Zhi-Ling; Zhao, Xin-Ye; Xiang, Chun-Jing; Wang, Hui; Fong, Wang-Fun; Ko, Kam-Ming
Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration
Planta medica, v. 73, (2), 2007, FEB, p. 134-141
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada H.Y.; Poon, Michel K.T.; Dong, Tina Tingxia; Tsim, Karl Wah Keung; Ko, Kam Ming
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs
Chinese Medicine, v. 2, 2007
Ko, Kam Ming; Leung, Hoi Yan
Evaluation of acute bis(7)-tacrine treatment on behavioral functions in 17-day-old and 30-day-old mice, with attention to drug toxicity
Pharmacology BIOCHEMISTRY and Behavior, v. 86, (4), 2007, APR, p. 778-783
Pan, Si Yuan; Yu, Zhi Ling; Dong, Hang; Lee, Nelson Tsz Kin; Wang, Hui; Fong, Wang Fun; Han, Yi Fan; Ko, Kam Ming
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers
Biological & pharmaceutical bulletin, v. 30, (6), 2007, JUN, p. 1108-1112
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Ko, Kam Ming
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts
ACTA PHARMACOLOGICA SINICA, v. 28, (10), 2007, OCT, p. 1559-1565
Chiu, Po-Yee; Leung, Hoi-Yan; Siu, Ada Hoi Ling; Poon, Michel Kwong Tat; Ko, Kam-Ming


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Article 14

(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes
Molecular and cellular biochemistry, v. 289, (1-2), 2006, SEP, p. 185-191
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Mak, Duncan H.F.; Ko, Kam Ming
A characteristic pharmacological action of `Yang-invigorating' Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity
Phytomedicine, v. 13, (9-10), 2006, NOV, p. 636-642
Ko, Kam-Ming; Leon, T.Y.Y.; Mak, Duncan H.F.; Chiu, Po-Yee; Du, Ying; Poon, Michel Kwong Tat
A novel experimental model of acute hypertriglyceridemia induced by schisandrin B
European journal of pharmacology, v. 537, (1-3), 2006, MAY 10, p. 200-204
Pan, Si Yuan; Dong, Hang; Han, Yi Fan; Li, Wen Yuan; Zhao, Xing Y.; Ko, Kam Ming
Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice
European journal of pharmacology, v. 552, (1-3), 2006, DEC 15, p. 170-175
Pan, Si-Yuan; Yang, Rong; Dong, Hang; Yu, Zhi-ling; Ko, Kam-Ming
Biochemical basis of the "Qi-invigorating" action of Schisandra berry (Wu-Wei-Zi) in Chinese medicine
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 34, (2), 2006, p. 171-176
Ko, Kam Ming; Chiu, Po Yee
Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats
Biogerontology, v. 7, (4), 2006, AUG, p. 199-210
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Ko, Kam Ming
Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes
Phytotherapy research, v. 20, (7), 2006, JUL, p. 561-567
Mak, Duncan Hon Fai; Chiu, Po Yee; Dong, Tina Ting Xia; Tsim, Karl Wah Keung; Ko, Kam Ming
Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts
Molecular and cellular biochemistry, v. 288, (1-2), 2006, AUG, p. 135-142
Du, Ying; Ko, Kam Ming
Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes
Pharmacology, v. 77, (2), 2006, p. 63-70
Chiu, PY; Leung, HY; Poon, MKT; Mak, DHF; Ko, KM
Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17-and 30-day-old mice
Pharmacology BIOCHEMISTRY and Behavior, v. 85, (1), 2006, SEP, p. 50-56
Pan, Si Yuan; Han, Yi Fan; Yu, Zhi Ling; Yang, Rong; Dong, Hang; Ko, Kam Ming
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia
ACTA PHARMACOLOGICA SINICA, v. 27, (6), 2006, JUN, p. 673-678
Pan, Si Yuan; Yang, Rong; Han, Yi Fan; Dong, Hang; Feng, Xu Dong; Li, Na; Geng, Wei; Ko, Kam Ming
Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats
Planta medica, v. 72, (3), 2006, FEB, p. 222-227
Du, Ying; Ko, Kam Ming
Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver
Molecular and cellular biochemistry, v. 293, (1-2), 2006, DEC, p. 87-92
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Lee, Susanna S.T.; Ko, Kam Ming
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells
BioFactors, v. 26, (4), 2006, p. 221-230
Chiu, Po Yee; Ko, Kam Ming


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Article 4

A Yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats
Rejuvenation research, v. 8, (4), 2005, WIN, p. 238-247
Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel Kwong Tat; Ko, Kam Ming
Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference
Life sciences, v. 77, (22), 2005, OCT 14, p. 2770-2782
Du, Ying; Ko, Kam Ming
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver
Life sciences, v. 77, (23), 2005, OCT 21, p. 2887-2895
Chiu, PY; Mak, DHF; Poon, MKT; Ko, KM
Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells
Molecular and cellular biochemistry, v. 276, (1-2), 2005, AUG, p. 227-234
Ko, Kam Ming; Chiu, Po Yee

Conference paper 1

A "Yang-invigorating" Chinese herbal suppository preparation relieves symptoms in patients with Parkinson's disease
New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005, 2005, p. 243-246
Ko, KM; Chan, K.; Shek, L.; Yeung, J.; Chui, SH


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Article 6

A Yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects
Phytotherapy research, v. 18, (7), 2004, JUL, p. 525-530
Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Ng, Timothy TL; Chung, YK; Lam, BYH; Du, Ying; Ko, KM
Comparing an in vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs
Phytotherapy research, v. 18, (2), 2004, FEB, p. 149-153
Beissenhirtz, Moritz K.; Kwan, Roger Cheuk Hung; Ko, Kam Ming; Renneberg, Reinhard; Scheller, Frieder W.; Lisdat, Fred
Pharmacological basis of `Yang-invigoration' in Chinese medicine
Trends in pharmacological sciences, v. 25, (1), 2004, JAN, p. 3-6
Ko, Kam Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat
Pharmacological basis of `Yin-nourishing' and `Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb
Life sciences, v. 76, (4), 2004, DEC 10, p. 385-395
Siu, Kai Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Du, Ying; Ko, KM
Processing control of Chinese herbal products: An ultimate approach for quality assurance
Asia-Pacific Biotech News, v. 8, (23), 2004, p. 1338-1341
Ko, Robert Kam Ming; Ng, Ka Ming
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats
Molecular and cellular biochemistry, v. 266, (1-2), 2004, NOV, p. 139-144
Chiu, Po Yee; Ko, Kam Ming

Book chapter 1

Deciphering the Myth of Fructus Schisandrae in Traditional Chinese Medicine: Biochemical Basis of its Qi-invigorating Action
Recent Progress in Medicinal Plants Volume 9: Plant Bioactives in Traditional Medicine / J.N. Govil, V.K. Singh, Rajeev Kr. Sharma. Studium Press LLC, 2005, p. 147-163
Ko, K.M.; Chiu, P.Y.


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Article 6

Challenges in the globalization of Chinese herbal medicine
Asia-Pacific Biotech News., 7:1287-89
Ko, K.M.
East meets west in anti-aging medicine
Annal Asia Anti-aging Med. Assoc., 2004:39-44
Ko, K.M.
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice
BioFactors, v. 19, (1-2), 2003, p. 33-42
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming
Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins
FREE RADICAL BIOLOGY AND MEDICINE, v. 35, (4), 2003, AUG 15, p. 368-380
Chiu, Po Yee; Tang, Man Ho; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ko, Kam Ming
Metformin protects against carbon tetrachlordie hepatootoxicity in mice: Enhancement of mitochondrial glutathione redox status
Journal of pharmacological sciences, v. 93, (4), 2003, DEC, p. 501-504
Poon, Michel Kwong Tat; Chiu, Po Yee; Mak, Duncan Hon Fai; Ko, Kam Ming
Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury
BioFactors, v. 19, (1-2), 2003, p. 43-51
Chiu, Po Yee; Ko, Kam Ming

Book 1

Schisandrin B and other Dibenzocyclooctadiene lignans. In: Herbal Medicines: Molecular Basis in Health & Diseases Management
Marcel Dekker: New York, Basel, Hong Kong / 289-314
Ko, K.M.

Conference paper 3

Anti-aging effects of a Chinese medicine preparation on elderly male subjects
2nd Asia Pacific Conferenece and Exhibition on Anti-Aging Medicine, Singapore, p.73, September
Ko, K.M.
Antioxidant potential of a Chinese Medicine Preparation in vitro and in vivo/ex vivo
2nd Asia Pacific Conference and Exhibition on Anti-Aging Medicine 2003, Singapore, p.50, September
Ko, K.M.; Mak, Duncan H.F.; Poon, Michel K.T.
Biochemical, immunological, hormonal and anti-oxidant effects of a Chinese Herbal Suppository, Vigconic HY28, on Elderly Male Subjects - An anti-aging solution?
Anti-Aging World Conference, Paris, France, p.105
Chui, Siu Hon; Ko, Kam Ming


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Article 5

Antioxidant and immunomodulatory activities of Chinese tonifying herbs
Pharmaceutical biology, v. 40, (5), 2002, AUG, p. 329-335
Yim, Tze Kin; Ko, Kam Ming
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin
Planta medica, v. 68, (11), 2002, NOV, p. 951-956
Chiu, Po Yee; Mak, Duncan Hon Fai; Poon, Michel Kong Tat; Ko, Kam Ming
Protection against carbon tetrachloride liver toxicity by enantiomers of schisandrin B associated with differential changes in hepatic glutathione antioxidant system in mice
Pharmaceutical biology, v. 40, (4), 2002, p. 298-301
Ko, Kam Ming; Poon, Michel Kwong Tat; Ip, Siu Po; Wu, Kim
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice
Planta medica, v. 68, (3), 2002, MAR, p. 217-220
Pan, Si Yuan; Han, Yi Fan; Carlier, Paul R.; Pang, Yuan Ping; Mak, Duncan Hon Fai; Lam, Brian Yee Hong; Ko, Kam Ming
Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
Molecular and cellular biochemistry, v. 238, (1-2), 2002, SEP, p. 181-186
Ko, Kam Ming; Lam, Brian Yee Hong

Book 1

Shengmai San
Shengmai San / Edited by Kam-Ming Ko. Taylor & Francis: London, 2002
Ko, Kam Ming

Book chapter 1

Pharmacological studies on Shengmai San
Shengmai San / Editied by Kam-Ming Ko. London: Taylor & Francis, 2002, p. 16-40
Ko, Kam Ming; Mak, Duncan Hon Fai; Yim, Tsz Kin; Yan, Yong Qing

Conference paper 3

A question of quality
Current Drug Discovery, (MAY), 2002, p. 41-42
Ko, Robert Kam Ming
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione antioxidant status and induction of heat shock proteins in mice.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p.77
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming
Time-dependent enhancement in mitochondrial glutathione antioxidant and functional status by schisandrin B treatment decrease the susceptibility of rats hearts to ischemia-reperfusion injury.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p. 75
Chiu, Po Yee; Ko, Kam Ming


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Article 5

Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants
Japanese journal of pharmacology, v. 85, (4), 2001, APR, p. 435-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Yiu, Ho Yan
Effects of Fructus Ligustri Lucidi extracts on concanavalin A-stimulated proliferation of isolated murine splenocytes
Pharmaceutical biology, v. 39, (2), 2001, p. 146-151
Yim, Tze Kin; Ko, Kam Ming
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver
Cell stress & chaperones, v. 6, (1), 2001, JAN, p. 44-48
Ip, Siu Po; Che, Chun Tao; Kong, Yun Cheung; Ko, Kam Ming
Hepatoprotective action of an oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice
Phytotherapy research, v. 15, (7), 2001, NOV, p. 589-592
Yim, Tze Kin; Wu, WK; Pak, WF; Ko, Kam Ming
Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts
Molecular and cellular biochemistry, v. 220, (1-2), 2001, APR, p. 141-147
Ko, Kam Ming; Yiu, Ho Yan


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Article 3

Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice
Molecular and cellular biochemistry, v. 205, (1-2), 2000, FEB, p. 111-114
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming
Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented `Dang-Gui Decoction for Enriching Blood', a compound formulation, ex vivo
Phytotherapy research, v. 14, (3), 2000, MAY, p. 195-199
Yim, Tze Kin; Wu, WK; Pak, WF; Mak, Duncan Hon Fai; Liang, SM; Ko, Kam Ming
Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity
Molecular and cellular biochemistry, v. 208, (1-2), 2000, MAY, p. 151-155
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming


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Article 2

Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats
Biochemical pharmacology, v. 57, (1), 1999, JAN 1, p. 77-81
Yim, Tze Kin; Ko, Kam Ming
Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status
Molecular and cellular biochemistry, v. 196, (1-2), 1999, JUN, p. 151-156
Yim, Tze Kin; Ko, Kam Ming


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Article 3

In vivo antioxidant mechanism of `Sheng Mai San', a compound formulation
Pharmaceutical biology, v. 36, (3), 1998, JUL, p. 189-193
Yick, Pak Kin; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming
Myocardial protective effect of an anthraquinone-containing extract of Polygonum multiflorum ex vivo
Planta medica, v. 64, (7), 1998, OCT, p. 607-611
Yim, Tze Kin; Wu, WK; Mak, Duncan Hon Fai; Ko, Kam Ming
Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice
ACTA PHARMACOLOGICA SINICA, v. 19, (4), 1998, JUL, p. 313-316
Ip, Siu Po; Che, Chun Tao; Ko, Kam Ming


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Article 4

Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and Schisandrin B treatment
Molecular and cellular biochemistry, v. 175, (1-2), 1997, OCT, p. 225-232
Mak, Duncan Hon Fai; Ko, Kam Ming
Antioxidant activities of Polygonum multiflorum Thunb, in vivo and in vitro
Phytotherapy research, v. 11, (1), 1997, FEB, p. 42-44
Ip, Siu Po; Tse, ASM; Poon, Michel Kwong Tat; Ko, Kam Ming; Ma, CY
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice
Biochemical pharmacology, v. 54, (2), 1997, JUL 15, p. 317-319
Ip, Siu Po; Ma, Cui Ying; Che, Chun Tao; Ko, Kam Ming
Protective effect of a lignan-enriched extract of fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy Research, v. 11, (8), 1997, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po


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Article 8

Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats
Molecular and cellular biochemistry, v. 162, (2), 1996, SEP 20, p. 153-158
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats
Pharmacology & toxicology, v. 78, (6), 1996, JUN, p. 413-416
Ip, Siu Po; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo
Molecular and cellular biochemistry, v. 165, (2), 1996, DEC 20, p. 161-165
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo
Phytomedicine, v. 3, (2), 1996, SEP, p. 217-221
Li, Pui Chun; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming
Protective effect of a lignan-enriched extract of Fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy research, v. 10, (5), 1996, AUG, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po
Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 24, (3-4), 1996, p. 255-262
Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming
Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver
FREE RADICAL BIOLOGY AND MEDICINE, v. 21, (5), 1996, p. 709-712
Ip, Siu Po; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming
The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene
Biochemical pharmacology, v. 52, (11), 1996, DEC 13, p. 1687-1693
Ip, Siu Po; Ko, Kam Ming


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Article 4

Effect of a lignan-enriched fructus Schisandrae extract on hepatic glutathione status in rats: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (2), 1995, APR, p. 134-137
Ko, Kam Ming; Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung
Effect of Schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (5), 1995, OCT, p. 398-401
Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming
Enhancement of hepatic glutathione regeneration capacity by a lignan-enriched extract of fructus schisandrae in rats
Japanese journal of pharmacology, v. 69, (4), 1995, DEC, p. 439-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po
Schisandra Chinensis-derived antioxidant activities in 'Sheng Mai San', a compound formulation, in vivo and in vitro
Phytotherapy research, v. 9, (3), 1995, MAY, p. 203-206
Ko, Kam Ming; Yick, Pak Kin; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung


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Article 1

Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids
Molecular and Cellular Biochemistry, v. 141, (1), p. 65-70
Ko, Kam Ming; Yick, Pak Kin; Poon, Michael K.T.; Ip, Siu Po


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Article 1

Impaired hepatic antioxidant status in carbon tetrachloride intoxicated rats: An in vivo model for screening herbal extracts with antioxidant activities
Fitoterapia, v. 64, (6), 1993, p. 539-544
Ko, Kam Ming; Yick, Pak Kin; Chiu, Tillie; Hui, T.Y.; Cheng, Christopher Hon Ki; Kong, Yun Cheung


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Article 1

Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol
Biochemical Pharmacology, v. 40, Issue 4, 15 August 1990, Pages 803-809
Ko, Kam Ming; Godin, David V.


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2016 7

A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration
PLoS One, v. 11, (3), March 2016, article number e0149663
Zhang, Liyun; Xiang, Lue; Liu, Yiwen; Venkatraman, Prahatha; Chong, Leelyn; Cho, Jin; Bonilla, Sylvia; Jin, Zi-Bing; Pang, Chi Pui; Ko, Robert K.M.; Ma, Ping; Zhang, Mingzhi; Leung, Yuk Fai Article
An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents
Chinese Medicine, v. 7, December 2016, p. 153-165
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Jihang; Zhu, Huawei; Ning, Jialing; Yang, Yiting; Ma, Chung Wah; Ko, Robert Kam Ming Article
Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response
PLoS ONE, v. 11, (5), May 2016, article number e0155879
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Leung, Hoi Yan; Ko, Kam Ming Article
Induction of the Glutathione Antioxidant Response/Glutathione Redox Cycling by Nutraceuticals: Mechanism of Protection against Oxidant-induced Cell Death
Current Trends in Nutraceuticals, v. 1, (1-2), March 2016, p. 1-9
Leong, Pou Kuan; Ko, Robert Kam Ming Article
Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease
Oxidative Medicine and Cellular Longevity, v. 2016, 2016, article number 6171658
Leong, Pou Kuan; Ko, Kam Ming Article
Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective
Chinese Medicine, v. 7, (3), August 2016
Chung, Yin Kwan; Chen, Jihang; Ko, Robert Kam Ming Article
β-Sitosterol increases mitochondrial electron transport by fluidizing mitochondrial membranes and enhances mitochondrial responsiveness to increasing energy demand by the induction of uncoupling in C2C12 myotubes
Journal of Functional Foods, v. 23, May 2016, p. 253-260
Wong, Hoi Shan; Leong, Pou Kuan; Chen, Jihang; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article

2015 17

A cistanches herba fraction/ β -sitosterol causes a redox-sensitive induction of mitochondrial uncoupling and activation of adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 in C2C12 myotubes: A possible mechanism underlying the weight reduction effect
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 142059
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming Article
A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice
Lipids in Health and Disease, v. 14, (1), August 2015, article number 97
Chu, Zhusheng; Yu, Zhiling; Pan, Siyuan; Jia, Zhanhong; Wang, Xiaoyan; Zhang, Yi; Zhu, Peili; Wang, Xiujuan; Ko, Kamming Article
A traditional Chinese medicine approach in treating depression by promoting liver Qi circulation: A western medicine perspective
Chinese Medicine, v. 6, (4), November 2015, p. 187-195
So, Raphaella Wai Lam; Wong, Hoi Shan; Ko, Robert K.M. Article
Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice
Drug Design, Development and Therapy, v. 9, February 2015, p. 923-935
Zhu, Pei-Li; Pan, Si-Yuan; Zhou, Shu-Feng; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming Article
Evaluation of a topical herbal agent for the promotion of bone healing
Evidence-based Complementary and Alternative Medicine, v. 2015, February 2015, article number 905270
Siu, Wingsum; Ko, Chunhay; Lam, Ka Wing; Wat, Elaine C.L.; Shum, Waiting; Lau, Clara; Ko, Kam Ming; Hung, Leung Kim; Lau, David Tai Wai; Leung, Pingchung Article
Hawthorn Nectar Enhances Gastrointestinal Motility as Well as Stimulates Intestinal Amylase and Lipase Activities in Mice
Chinese Medicine, v. 6, September 2015, article number 59435, p. 159-168
Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Poukuan; Leung, Hoiyan; Chan, Wingman; Wong, Hoi Shan; Ko, Robert K.M. Article
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan Article
Lily bulb nectar produces expectorant and anti-tussive activities, and suppresses cigarette smoke-induced inflammatory response in the respiratory tract in mice
Chinese Medicine, v. 6, June 2015, article number 56861, p. 136-146
Wong, Hoi Shan; Zou, Shiyu; Li, Jiangping; Ma, Chungwah; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article
Mitochondrial reactive oxygen species production mediates ursolic acid-induced mitochondrial uncoupling and glutathione redox cycling, with protection against oxidant injury in H9c2 cells
Food and Function, v. 6, (2), February 2015, p. 549-557
Chen, Jihang; Wong, Hoi Shan; Ko, Kam Ming Article
New perspectives on dietary-derived treatments and food safety – Antinomy in a new era
Critical Reviews in Food Science and Nutrition, v. 55, (13), November 2015, p. 1836-1859
Pan, Si-Yuan; Gao, Si-Hua; Lin, Rui-Chao; Zhou, Shu-Feng; Dong, Hong-Guan; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M. Article
Schisandrin B Ameliorates ICV-Infused Amyloid beta Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-kappa B/MAPK and Up-Regulating HSP/Beclin Expression
PLoS One, v. 10, (11), November 2015, article number e0142483
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Arumugam, Somasundaram; Mizuno, Makoto; Nawa, Hiroyuki; Suzuki, Kenji; Ko, Robert K.M.; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya Article
Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo
BioFactors, v. 41, (5), September 2015, p. 314-323
Leong, Pou-Kuan; Ko, Kam-Ming Article
Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: Implications for its hepatotoxicity
Drug Design, Development and Therapy, v. 9, April 2015, p. 2001-2027
Zhang, Yi; Zhou, Zhiwei; Jin, Hua; Hu, Chengbin; He, Zhixu; Yu, Zhiling; Ko, Robert K.M.; Yang, Tianxin; Zhang, Xueji; Pan, Siyuan; Zhou, Shufeng Article
Schisandrin B Prevents Doxorubicin Induced Cardiac Dysfunction by Modulation of DNA Damage, Oxidative Stress and Inflammation through Inhibition of MAPK/p53 Signaling
PLoS ONE, v. 10, (3), March 2015, article number e0119214
Thandavarayan, Rajarajan A.; Giridharan, Vijayasree V.; Arumugam, Somasundaram; Suzuki, Kenji; Ko, Kam Ming; Krishnamurthy, Prasanna; Watanabe, Kenichi; Konishi, Tetsuya Article
Yang/Qi invigoration: An herbal therapy for chronic fatigue syndrome with yang deficiency?
Evidence-based Complementary and Alternative Medicine, v. 2015, 2015, article number 945901
Leong, Pou Kuan; Wong, Hoi Shan; Chen, Jihang; Ko, Kam Ming Article
Schisandra Chinensis: An Herb of North Eastern China Origin
Schisandra Chinensis: An Herb of North Eastern China Origin / by Kam-Ming Ko , Jun Yin and Chuixin Qin. Singapore: World Scientific Publishing, 2015.
Ko, Kam Ming; Yin, Jun; Qin, Chuixin Book
An investigation of anti-inflammatory activities produced by schisandrin A and schisandrin B in vitro and in vivo
12th World Congress on Inflammation, Boston, MA, USA, 8-12 August 2015
Leong, Pou Kuan; Ko, Robert K.M. Conference paper

2014 17

Acute and Long-term Treatment with an Herbal Formula V-Vital Capsule Increase Exercise Endurance Capacity in Weight-loaded Swimming Mice
Chinese Medicine, v. 5, (3), September 2014, p. 153-164
Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Chen, Ji Hang; Wong, Hoi Shan; Ma, Chung Wah; Zou, Shi Yu; Ko, Robert K.M. Article
An ursolic acid-enriched Cynomorium songarium extract attenuates high fat diet-induced obesity in mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 9, July 2014, p. 211-224
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Ko, Robert Kam Ming Article
An ursolic acid-enriched extract of Cynomorium songaricum protects against carbon tetrachloride hepatotoxicity and gentamicin nephrotoxicity in rats possibly through a mitochondrial pathway: A comparison with ursolic acid
Journal of Functional Foods, v. 7, (1), 2014, p. 330-341
Chen, Jihang; Wong, Hoi Shan; Leung, Hoi Yan; Leong, Pou Kuan; Chan, Wing Man; Chen, Na; Ko, Kam Ming Article
Cistanches Herba reduces the weight gain in high fat diet-induced obese mice possibly through mitochondrial uncoupling
Journal of Functional Foods, v. 10, September 2014, p. 292-304
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert K.M. Article
Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet
Lipids in Health and Disease, v. 13, (1), March 2014, article number 46
Sun, Nan; Pan, Si-Yuan; Zhang, Yi; Wang, Xiao-Yan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Zhou, Shu-Feng; Ko, Robert K M Article
Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 525340
Pan, Si-Yuan; Litscher, Gerhard; Gao, Si-Hua; Zhou, Shu-Feng; Yu, Zhi-Ling; Chen, Hou-Qi; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ko, Kam-Ming Article
Long-term Treatment with an Herbal Formula MCC Ameliorates Obesity-associated Metabolic Dysfunction in High Fat Diet-induced Obese Mice: a Comparative Study among MCC and Various Combinations of its Constituents
Chinese Medicine, v. 5, (1), March 2014, article number 44280, p. 34-46
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Chan, Wing Man; Ma, Chung Wah; Yang, Yi Ting; Ko, Robert K.M. Article
New insights into the chemical and biochemical basis of the "yang-invigorating" action of chinese yang-tonic herbs
Evidence-based Complementary and Alternative Medicine, v. 2014, December 2014, article number 856273
Chen, Jihang; Wong, Hoi Shan; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Kam Ming Article
Quality Assurance of Chinese Herbal Medicines: Procedure for Multiple-Herb Extraction
AIChE journal, v. 60, (12), December 2014, p. 4014-4026
Lau, Yeuk Tin; Ng, Ka Ming; Chen, Na; Lau, David T.W.; Ko, Robert K.M.; Leung, Ping Chung; Wibowo, Christianto Article
Schisandrin B enhances glutathione redox cycling and protects against β-amyloid-induced apoptosis in human neuroblastoma SH-SY5Y cells: A comparative study of various phytochemicals
The Open Nutraceuticals Journal, v. 7, (1), December 2014 , p. 49-57
Leong, Pou Kuan; Lam,Yeung; Chen, Na; Ko, Kam Ming Article
Supplementation with the Extract of Schisandrae Fructus Pulp, Seed, or Their Combination Influences the Metabolism of Lipids and Glucose in Mice Fed with Normal and Hypercholesterolemic Diet
Evidence-based Complementary and Alternative Medicine, v. 2014, 2014, article number 472638
Wang, Xiao-Yan; Yu, Zhi-Ling; Pan, Si-Yuan; Zhang, Yi; Sun, Nan; Zhu, Pei-Li; Jia, Zhan-Hong; Zhou, Shu-Feng; Ko, Kam-Ming Article
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
Drug Design, Development and Therapy, v. 8, September 2014, p. 1429-1439
Zhang, Yi; Pan, Si-Yuan; Zhou, Shu-Feng; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Chu, Zhu-Sheng; Yu, Zhi-Ling; Ko, Kam-Ming Article
Ursolic Acid-Enriched Herba Cynomorii Extract Induces Mitochondrial Uncoupling and Glutathione Redox Cycling Through Mitochondrial Reactive Oxygen Species Generation: Protection Against Menadione Cytotoxicity in H9c2 Cells
Molecules, v. 19, January 2014, p. 1576-1591
Chen, Jihang; Wong, Hoi Shan; Ko, Robert Kam Ming Article
β-Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts
PTR. Phytotherapy research, v. 28, (7), July 2014, p. 999-1006
Wong, Hoi Shan; Chen, Na; Leong, Pou Kuan; Ko, Robert Kam Ming Article
β-Sitosterol Protects against Carbon Tetrachloride Hepatotoxicity but not Gentamicin Nephrotoxicity in Rats via the Induction of Mitochondrial Glutathione Redox Cycling
Molecules, v. 19, (11), October 2014, p. 17649-17662
Wong, Hoi Shan; Chen, Jihang; Leong, Pou Kuan; Leung, Hoi Yan; Chan, Wing Man; Ko, Robert Kam Ming Article
Pharmacological profile of dibenzocyclooctadiene lignans and other active ingredients in Schisadrae Fructus
Schisandra Chinensis: An Herb of North Eastern China Origin / By Kam-Ming Ko, Jun Yin, Chuixin Qin. World Scientific, 2014, p. 97-138, Ch. 4
Ko, Robert K.M.; Chen, Na; Leong, Pou Kuan; Ma, Chung Wah Book chapter
Schisandrin B suppresses the lipopolysaccharide/ATP-induced Inflammasome Activation and Cytotoxicity in Isolated Mouse Peritoneal Macrophages and Cultured RAW264.7 Macrophages via Eliciting Nrf2-driven Antioxidant Response
The 8th Pong Ding Yuen International Symposium on Traditional Chinese Medicine cum The 2nd International Chinese Symposium on Free Radical Research & The 6th Symposium for Three Districts of Cross-straits on Free Radical Research, Hong Kong, 15-16 November 2014
Leong, Pou Kuan; Ko, Kam Ming Conference paper

2013 7

A Novel Mouse Model of Combined Hyperlipidemia Associated With Steatosis and Liver Injury by a Single-Dose Intragastric Administration of Schisandrin B/Cholesterol/Bile Salts Mixture
Journal of Pharmacological Sciences, v. 123, (2), 2013, p. 110-119
Pan, Si-Yuan; Jia, Zhan-Hong; Zhang, Yi; Yu, Qing; Wang, Xiao-Yan; Sun, Nan; Zhu, Pei-Li; Yu, Zhi-Ling; Ko, Robert K.M. Article
Caspase-3-Dependent Apoptosis of Citreamicin ε-Induced HeLa Cells Is Associated with Reactive Oxygen Species Generation
Chemical Research in Toxicology, v. 26, (7), July 2013, p. 1055-1063
Liu, Lingli; He, Lisheng; Xu, Sharon Ying; Han, Zhuang; Li, Yongxin; Zhong, Jialiang; Guo, Xianrong; Zhang, Xixiang; Ko, Robert K.M.; Qian, Peiyuan Article
Herba Cistanches stimulates cellular glutathione redox cycling by reactive oxygen species generated from mitochondrial respiration in H9c2 cardiomyocytes
Pharmaceutical Biology, v. 51, (1), 2013, p. 64-73
Wong, Hoi Shan; Ko, Robert K.M. Article
Long-Term Treatment with an Herbal Formula MCC Reduces the Weight Gain in High Fat Diet-Induced Obese Mice
Chinese Medicine, v. 4, (3), September 2013, article number 36112, p. 63-71
Leong, Pou Kuan; Leung, Hoi Yan; Wong, Hoi Shan; Chen, Jihang; Ma, Chung Wa; Yang, Yiting; Ko, Robert K.M. Article
New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics
Evidence-based Complementary and Alternative Medicine, v. 2013, 2013, article number 627375
Pan, Si-Yuan; Zhou, Shu-Feng; Gao, Si-Hua; Yu, Zhi-Ling; Zhang, Shuo-Feng; Tang, Min-Ke; Sun, Jian-Ning; Ma, Dik-Lung; Han, Yi-Fan; Fong, Wang-Fun; Ko, Robert K.M. Article
Schisandrin B enhances hepatic/myocardial glutathione regeneration capacity and protects against oxidant injury in rat livers and hearts
The Open Nutraceuticals Journal, v. 6, (1), 2013, p. 124-128
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling
Evidence-Based Complementary and Alternative Medicine, v. 2013, March 2013, article number 924128
Chen, Jihang; Ko, Robert K.M. Article

2012 15

"Qi-Invigorating” Chinese Tonic Herbs (Shens) Stimulate Mitochondrial ATP Generation Capacity in H9c2 Cardiomyocytes in Situ and Rat Hearts ex Vivo
Chinese Medicine, v. 3, (2), June 2012, p. 101-105
Wong, Hoi Shan; Cheung, Weng Fat; Tang, Wai Ling; Ko, Robert K.M. Article
A Hypothetical Anti-Aging Mechanism of “Yang-Invigorating” Chinese Tonic Herbs
Chinese Medicine, v. 3, (1), March 2012, article number 18126
Lam, Yeung; Wong, Hoi Shan; Chen, Jihang; Ko, Robert K.M. Article
Beneficial effect of (-)Schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells
BioFactors, v. 38, (3), May/June 2012, p. 219-225
Lam, Yeung; Ko, Robert K.M. Article
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes
Cell Biology International, v. 36, (3), March 2012, p. 321-326
Leong, Pou Kuan; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes
Indian Journal of Pharmacology, v. 44, (2), March 2012, p. 204-209
Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity
Lipids in Health and Disease, v. 11, September 2012, article number 120
Pan, Si-Yuan; Yu, Qing; Zhang, Yi; Wang, Xiao-Yan; Sun, Nan; Yu, Zhi-Ling; Ko, Robert K.M. Article
Long-Term Treatment with a Health Product (Squina Diacylglyceryl Ether) Enhances Innate and Adaptive Immunity in Mice
Journal of Complementary and Integrative Medicine, v. 9, (1), November 2012
Leung, Hoi Yan; Ko, Robert K.M. Article
Mitochondrial decay in ageing: 'Qi-invigorating' schisandrin B as a hormetic agent for mitigating age-related diseases
Clinical and Experimental Pharmacology & Physiology, v. 39, (3), March 2012, p. 256-264
Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity
Journal of Medicinal Food, v. 15, (7), June 2012, p. 629-638
Lam, Yeung; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
New Perspectives on Complementary and Alternative Medicine: An Overview and Alternative Therapy
Alternative Therapies in Health and Medicine, v. 18, (4), July 2012, p. 20-36
Pan, Si-Yuan; Gao, Si-Hua; Zhou, Shu-Feng; Tang, Min-Ke; Yu, Zhi-Ling; Ko, Robert K.M. Article
Product Design: A Nanomized Nutraceutical with Enhanced Bioactivity and Bioavailability
Industrial & Engineering Chemistry Research, v. 51, (21), May 2012, p. 7320-7326
Lau, Yeuk Tin; Chen, Na; Ko, Robert K.M.; Ng, Ka Ming Article
Prooxidant-Induced Glutathione Antioxidant Response in Vitro and in Vivo: A Comparative Study between Schisandrin B and Curcumin
Biological and Pharmaceutical Bulletin, v. 35, (4), April 2012, p. 464-472
Leong, Pou Kuan; Chiu, Po Yee; Ko, Robert K.M. Article
Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases
Oxidative Medicine and Cellular Longevity, v. 2012, March 2012, article number 250825
Lam, Yeung; Ko, Robert K.M. Article
Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice
Free Radical Research, v. 46, (1), January 2012, p. 50-60
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Bhilwade, Hari N.; Ko, Robert K.M.; Watanabe, Kenichi; Konishi, Tetsuya Article
五味子及其成分的药理毒理研究
东北道地药材-五味子 - Schisandra chinensis from North East China / 殷军. 中国医药科技出版社, 2012, p. 74-129
Ko, Robert Kam Ming; Chen, Na; Hua, Y.L. Book chapter

2011 20

(-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells
BioFactors, v. 37, (1), January/February 2011, p. 51-57
Lam, Yeung; Ko, Robert K.M. Article
‘Yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes
Chinese Medicine, v. 2, March 2011
Wong, Hoi Shan; Leung, Hoi Yan; Ko, Robert K.M. Article
A Proteomic Approach in Investigating the Hepatoprotective Mechanism of Schisandrin B: Role of Raf Kinase Inhibitor Protein
Journal of proteome research, v. 10, (1), January 2011, p. 299-304
Chen, Yan; Ip, Siu-Po; Ko, Robert K.M.; Poon, Terence C.W.; Ng, Eddy W.Y.; Lai, Paul B.S.; Mao, Qing-Qiu; Xian, Yan-Fang; Che, Chun-Tao Article
Acute treatment with Danshen–Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKC?/mK_ATP pathway in rats
Phytomedicine, v. 18, (11), August 2011, p. 916-925
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Co-treatment with shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats
Rejuvenation Research, v. 14, (1), February 2011, p. 17-23
Chiu, Po Yee; Lam, Yeung; Leung, Hoi Yan; Leong, Pou Kuan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M. Article
Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKC?/mK_ATP pathways in H9c2 cardiomyocytes
Phytomedicine, v. 19, (2), January 2012, p. 99-110
Chiu, Po Yee; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zou, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 383, (6), June 2011, p. 585-591
Pan, Si-Yuan; Dong, Hango; Guo, Bao-Feng; Zhang, Yi; Yu, Zhi-Ling; Fong, Wang-Fun; Han, Yi-Fan; Ko, Robert K.M. Article
Ethanol Extract of Fructus Schisandrae Decreases Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet, with Attention to Acute Toxicity
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Yu, Zhi-Ling; Dong, Hang; Xiang, Chun-Jing; Fong, Wang-Fun; Ko, Robert K.M. Article
Immunopotentiating Activity of Dendrobium Species in Mouse Splenocytes
Chinese Medicine, v. 2, (3), September 2011, p. 103-108
Lau, David T.W.; Poon, Michel K.T.; Leung, Hoi Yan; Ko, Robert K.M. Article
Long-term treatment with danshen-gegen decoction protects the myocardium against Ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK_ATP pathway in rats
Rejuvenation Research, v. 14, (2), May 2011, p. 173-184
Chiu, Po Yee; Wong, Sze Man; Leung, Hoi Yan; Leong, Pou Kuan; Chen, Na; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mK_ATP-mediated pathway in rats
Chinese Medicine, v. 6, February 2011, article number 7
Wong, Sze Man; Chiu, Po Yee; Leung, Hoi Yan; Zhou, Limin; Zuo, Zhong; Lam, Yeung; Ko, Robert K.M. Article
New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development
Evidence-Based Complementary and Alternative Medicine, v. 2011, 2011
Pan, Si-Yuan; Chen, Si-Bao; Dong, Hong-Guang; Yu, Zhi-Ling; Dong, Ji-Cui; Long, Zhi-Xian; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M. Article
Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice
Free Radical Research, v. 45, (8), August 2011, p. 950-958
Giridharan, Vijayasree V.; Thandavarayan, Rajarajan A.; Sato, Shinji; Ko, Robert K.M.; Konishi, Tetsuya Article
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes
Free Radical Research, v. 45, (4), 2011, p. 483-495
Leong, Pou Kuan; Chiu, Po Yee; Chen, Na; Leung, Hoi Yan; Ko, Kam Ming Article
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells
Molecular and Cellular Biochemistry, v. 350, (1-2), April 2011, p. 237-250
Chiu, Po Yee; Chen, Na; Leong, Po Kuan; Leung, Hoi Yan; Ko, Robert K.M. Article
Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells
BioFactors, v. 37, (6), November/December 2011, p. 439-446
Lam, Yeung; Leong, Pou Kuan; Chen, Na; Ko, Robert K.M. Article
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts
Fitoterapia, v. 82, (4), June 2011, p. 682-691
Chiu, Po Yee; Lam, Yeung; Yan, Chung Wai; Ko, Robert K.M. Article
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue
Fitoterapia, v. 82, (3), April 2011, p. 393-400
Lam, Yeung; Yan, Chung Wai; Chiu, Po Yee; Leung, Hoi Yan; Ko, Robert K.M. Article
Tacrine and Bis(7)-Tacrine Attenuate Cycloheximide-Induced Amnesia in Mice, with Attention to Acute Toxicity
Basic & Clinical Pharmacology & Toxicology, v. 109, (4), October 2011, p. 261-265
Pan, Si-Yuan; Zhang, Yi; Guo, Bao-feng; Han, Yi-Fan; Ko, Robert K.M. Article
Tacrine Treatment at High Dose Suppresses the Recognition Memory in Juvenile and Adult Mice with Attention to Hepatotoxicity
Basic & Clinical Pharmacology & Toxicology, v. 108, (6), June 2011, p. 421-427
Pan, Si-Yuan; Guo, Bao-Feng; Zhang, Yi; Yu, Qing; Yu, Zhi-Ling; Dong, Hang; Ye, Yan; Han, Yi-Fan; Ko, Robert K.M. Article

2010 10

A Red Wine Extract Supplement Protects against Apoptosis and Inhibits Changes in Mitochondrial Permeability and Membrane Potential
Journal of Complementary and Integrative Medicine, v. 7, (1), January 2010
Chen, Na; Chiu, Po Yee; Ko, Robert K.M. Article
Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells
Journal of Ethnopharmacology, v. 128, (1), March 2010, p. 116-122
Chen, Meng-Li; Ip, Siu-Po; Tsai, Sam-Hip; Ko, Robert K.M.; Che, Chun-Tao Article
Herba Cistanche extract enhances mitochondrial glutathione status and respiration in rat hearts, with possible induction of uncoupling proteins
Pharmaceutical Biology, v. 48, (5), April 2010, p. 512-517
Siu, A.H.L.; Ko, Robert K.M. Article
Long-Term Dietary Supplementation with a Yang-Invigorating Chinese Herbal Formula Increases Lifespan and Mitigates Age-Associated Declines in Mitochondrial Antioxidant Status and Functional Ability of Various Tissues in Male and Female C57BL/6J Mice
Rejuvenation Research, v. 13, (2-3), May 2010, p. 168-171
Ko, Robert K.M.; Chiu, Po Yee; Leung, Hoi Yan; Siu, A.H.L.; Chen, Na; Leong, Eriol Pou Kwan; Poon, Michel K.T. Article
Long-Term Treatment with a "Yang-Invigorating" Chinese Herbal Formula, Wu-Zi-Yan-Zong-Wan, Reduces Mortality and Liver Oxidative Damage in Chronic Alcohol-Intoxicated Rats
Rejuvenation Research, v. 13, (4), August 2010, p. 459-467
Chen, Meng-Li; Tsai, Sam-Hip; Ip, Siu-Po; Ko, Robert K.M.; Che, Chun-Tao Article
Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity
Journal of Medicinal Food, v. 13, (2), April 2010, p. 427-438
Leong, Pou Kuan; Chen, Na; Chiu, Po Yee; Leung, Hoi Yan; Ma, Chung Wah; Tang, Qing Tao; Ko, Robert K.M. Article
New perspectives on innovative drug discovery: An overview
Journal of Pharmacy and Pharmaceutical Sciences, v. 13, (3), 2010, p. 450-471
Pan, Si-Yuan; Pan, Shan; Yu, Zhi-Ling; Ma, Dik-Lung; Chen, Si-Bao; Fong, Wang-Fun; Han, Yifan; Ko, Robert K.M. Article
Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats
Fitoterapia, v. 81, (8), December 2010, p. 1239-1245
Lam, Yeung; Chiu, Po Yee; Leung, Hoi Yan; Chen, Na; Leong, Pou Kuan; Ko, Robert K.M. Article
Schisandrin B-Induced Glutathione Antioxidant Response and Cardioprotection are Mediated by Reactive Oxidant Species Production in Rat Hearts
Biological and Pharmaceutical Bulletin, v. 33, (5), May 2010, p. 825-829
Chen, Na; Ko, Robert K.M. Article
Antioxidant and anticarcinogenic potential of sesame lignans
Sesame: The genus Sesamum. Medicinal and Aromatic Plants – Industrial Profiles. / Edited by Dorothea Bedigian. Boca Raton : CRC Press, Taylor & Francis Group, 2010, p. 111-131, Ch. 5
Mak, Duncan H.K.; Chiu, Po Yee; Ko, Robert Kam Ming Book chapter

2009 10

An integrative approach to product development-A skin-care cream
Computers & chemical engineering, v, 33, (5), May 2009, p. 1097-1113
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto Article
Comparison Studies of Tacrine and Bis(7)-Tacrine on the Suppression of Scopolamine-Induced Behavioral Changes and Inhibition of Acetylcholinesterase in Mice
Pharmacology, v. 83, (5), 2009, article number PHA2, p. 294-300
Pan, Si-Yuan; Yu, Zhi-Ling; Xiang, Chun-Jing; Dong, Hang; Fang, Hai-Yan; Ko, Kam-Ming Article
Effect of Extraction Solvent on the Bioactivity of an Herbal Formulation
Industrial and Engineering Chemistry Research, v. 48, (10), May 2009, p. 4852-4857
Chan, Kin N.; Lau, Choi C.; Chow, King Lau; Ko, Robert Kam Ming; Tsim, Karl Wah Keung; Ng, Ka Ming Article
Effects of peony glycosides on mice exposed to chronic unpredictable stress: Further evidence for antidepressant-like activity
Journal of ethnopharmacology, v. 124, (2), July 2009, p. 316-320
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Xian, Yan-Fang; Che, Chun-Tao Article
Exposure to oscillating high electrical potential and the associated low frequency magnetic field enhances the hepatoprotective action of schisandrin B in vivo and in vitro
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 23
Ko, Kam Ming; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Leung, Hoi Yan; Chiu, Po Yee Article
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
Nucleic acids research, v. 37, (17), September 2009, p. 5678-5689
Nishida, Hiroshi; Tatewaki, Naoto; Nakajima, Yuki; Magara, Taku; Ko, Kam Ming; Hamamori, Yasuo; Konishi, Tetsuya Article
Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: Effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor
Progress in neuro-psychopharmacology & biological psychiatry, v. 33, (7), October 2009, p. 1211-1216
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Che, Chun-Tao Article
Peony Glycosides Protect Against Corticosterone-Induced Neurotoxicity in PC12 Cells
Cellular and molecular neurobiology, v. 29, (5), July 2009, p. 643-647
Mao, Qing-Qiu; Ip, Siu-Po; Ko, Kam-Ming; Tsai, Sam-Hip; Zhao, Ming; Che, Chun-Tao Article
Protective effect of red wine extract supplement against myocardial ischemia/reperfusion injury in rats: Effects on mitochondrial antioxidant and structural parameters
Journal of Complementary and Integrative Medicine, v. 6, (1), 2009, article number 21
Ko, Kam Ming; Chen, Na; Chiu, Po Yee Article
Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation-induced Apoptosis and Associated Changes in the Ca-2+-induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in AML12 Hepatocytes
Phytotherapy research, v. 23, (11), November 2009, p. 1592-1602
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Robert Kam Ming Article

2008 13

A `Yang-invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats
Phytotherapy research, v. 22, (1), January 2008, p. 131-133
Poon, Michel Kwong Tat; Chiu, Po Yee; Leung, Hoi Yan; Sin, Ada Hoi Ling; Ko, Kam Ming Article
Herba Cistanche extract enhances mitochondrial ATP generation in rat hearts and H9C2 cells
Pharmaceutical biology, v. 46, (6), October 2008, p. 428-424
Leung, Hoi Yan; Ko, Kam Ming Article
Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice
BioFactors, v. 34, (4), December 2008, p. 331-342
Ko, Kam Ming; Chen, Na; Leung, Hoi Yan; Leong, Eriol P.K.; Poon, Michel K.T.; Chiu, Po Yee Article
Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis
Rejuvenation Research, v. 11, (6), December 2008, p. 991-1000
Zhang, Guang-Qin; Wang, Hui; Liu, Wen-Tao; Dong, Hang; Fong, Wang-Fun; Tang, Li-Min; Xiong, Yun-Hua; Yu, Zhi-Ling; Ko, Kam-Ming Article
Long-term treatment with a yang-invigorating chinese herbal formula produces generalized tissue protection against oxidative damage in rats
Rejuvenation research, v. 11, (1), February 2008, p. 43-62
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Chen, Na; Poon, Michel K.T.; Ko, Kam Ming Article
Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
Biological and Pharmaceutical Bulletin, v. 31, (7), July 2008, p. 1387-1391
Chen, Na; Chiu, Po Yee; Ko, Kam Ming Article
Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats
Biological & pharmaceutical bulletin, v. 31, (4), April 2008, p. 602-605
Chiu, Po Yee; Leung, Hoi Yan; Ko, Kam Ming Article
Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 60, (3), March 2008, p. 399-403
Pan, Si-Yuan; Dong, Hang; Zhao, Xing-Ye; Xiang, Chun-Jing; Fang, Hai-Yan; Fong, Wang-Fun; Yu, Zhi-Ling; Ko, Kam-Ming Article
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes
Life Sciences, v. 82, (21-22), May 2008, p. 1092-1101
Chiu, Po Yee; Luk, Ka Fai; Leung, Hoi Yan; Ng, Ka Ming; Ko, Kam Ming Article
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
Biochemical Engineering Journal, v. 42, (1), October 2008, p. 55-60
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Article
Separation and purification of schisandrin B from Fructus schisandrae
Industrial and Engineering Chemistry Research, v. 47, (12), June 2008, p. 4193-4201
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Article
Development of a skin-care cream containing zinc oxide nanoparticles and an herbal extract
2008 AIChE Annual Meeting, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008
Cheng, Yuen Shan; Lam, Ka Wing; Ng, Ka Ming; Ko, Robert Kam Ming; Wibowo, Christianto Conference paper
Separation and purification of (-)schisandrin B from schisandrin B stereoisomers
AIChE Annual Meeting, Conference Proceedings, AIChE 100, Philadelphia, PA, United States, 16-21 November 2008, 2008
Luk, Ka Fai; Ko, Robert Kam Ming; Ng, Ka Ming Conference paper

2007 6

Bicyclol, a synthetic dibenzocyclooctadiene derivative, decreases hepatic lipids but increases serum triglyceride level in normal and hypercholesterolaemic mice
Journal of Pharmacy and Pharmacology, v. 59, (12), 2007, DEC, p. 1657-1662
Pan, Si-Yuan; Dong, Hang; Yu, Zhi-Ling; Zhao, Xin-Ye; Xiang, Chun-Jing; Wang, Hui; Fong, Wang-Fun; Ko, Kam-Ming Article
Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: Role of glutathione synthesis and regeneration
Planta medica, v. 73, (2), 2007, FEB, p. 134-141
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada H.Y.; Poon, Michel K.T.; Dong, Tina Tingxia; Tsim, Karl Wah Keung; Ko, Kam Ming Article
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs
Chinese Medicine, v. 2, 2007
Ko, Kam Ming; Leung, Hoi Yan Article
Evaluation of acute bis(7)-tacrine treatment on behavioral functions in 17-day-old and 30-day-old mice, with attention to drug toxicity
Pharmacology BIOCHEMISTRY and Behavior, v. 86, (4), 2007, APR, p. 778-783
Pan, Si Yuan; Yu, Zhi Ling; Dong, Hang; Lee, Nelson Tsz Kin; Wang, Hui; Fong, Wang Fun; Han, Yi Fan; Ko, Kam Ming Article
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers
Biological & pharmaceutical bulletin, v. 30, (6), 2007, JUN, p. 1108-1112
Chiu, Po Yee; Leung, Hoi Yan; Siu, Ada Hoi Ling; Poon, Michel Kong Tat; Ko, Kam Ming Article
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts
ACTA PHARMACOLOGICA SINICA, v. 28, (10), 2007, OCT, p. 1559-1565
Chiu, Po-Yee; Leung, Hoi-Yan; Siu, Ada Hoi Ling; Poon, Michel Kwong Tat; Ko, Kam-Ming Article

2006 14

(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes
Molecular and cellular biochemistry, v. 289, (1-2), 2006, SEP, p. 185-191
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Mak, Duncan H.F.; Ko, Kam Ming Article
A characteristic pharmacological action of `Yang-invigorating' Chinese tonifying herbs: Enhancement of myocardial ATP-generation capacity
Phytomedicine, v. 13, (9-10), 2006, NOV, p. 636-642
Ko, Kam-Ming; Leon, T.Y.Y.; Mak, Duncan H.F.; Chiu, Po-Yee; Du, Ying; Poon, Michel Kwong Tat Article
A novel experimental model of acute hypertriglyceridemia induced by schisandrin B
European journal of pharmacology, v. 537, (1-3), 2006, MAY 10, p. 200-204
Pan, Si Yuan; Dong, Hang; Han, Yi Fan; Li, Wen Yuan; Zhao, Xing Y.; Ko, Kam Ming Article
Bifendate treatment attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice
European journal of pharmacology, v. 552, (1-3), 2006, DEC 15, p. 170-175
Pan, Si-Yuan; Yang, Rong; Dong, Hang; Yu, Zhi-ling; Ko, Kam-Ming Article
Biochemical basis of the "Qi-invigorating" action of Schisandra berry (Wu-Wei-Zi) in Chinese medicine
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 34, (2), 2006, p. 171-176
Ko, Kam Ming; Chiu, Po Yee Article
Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats
Biogerontology, v. 7, (4), 2006, AUG, p. 199-210
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Ko, Kam Ming Article
Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes
Phytotherapy research, v. 20, (7), 2006, JUL, p. 561-567
Mak, Duncan Hon Fai; Chiu, Po Yee; Dong, Tina Ting Xia; Tsim, Karl Wah Keung; Ko, Kam Ming Article
Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts
Molecular and cellular biochemistry, v. 288, (1-2), 2006, AUG, p. 135-142
Du, Ying; Ko, Kam Ming Article
Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes
Pharmacology, v. 77, (2), 2006, p. 63-70
Chiu, PY; Leung, HY; Poon, MKT; Mak, DHF; Ko, KM Article
Evaluation of acute tacrine treatment on passive-avoidance response, open-field behavior, and toxicity in 17-and 30-day-old mice
Pharmacology BIOCHEMISTRY and Behavior, v. 85, (1), 2006, SEP, p. 50-56
Pan, Si Yuan; Han, Yi Fan; Yu, Zhi Ling; Yang, Rong; Dong, Hang; Ko, Kam Ming Article
High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia
ACTA PHARMACOLOGICA SINICA, v. 27, (6), 2006, JUN, p. 673-678
Pan, Si Yuan; Yang, Rong; Han, Yi Fan; Dong, Hang; Feng, Xu Dong; Li, Na; Geng, Wei; Ko, Kam Ming Article
Oleanolic acid protects against myocardial ischemia-reperfusion injury by enhancing mitochondrial antioxidant mechanism mediated by glutathione and alpha-tocopherol in rats
Planta medica, v. 72, (3), 2006, FEB, p. 222-227
Du, Ying; Ko, Kam Ming Article
Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver
Molecular and cellular biochemistry, v. 293, (1-2), 2006, DEC, p. 87-92
Chiu, Po Yee; Leung, Hoi Yan; Poon, Michel K.T.; Lee, Susanna S.T.; Ko, Kam Ming Article
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells
BioFactors, v. 26, (4), 2006, p. 221-230
Chiu, Po Yee; Ko, Kam Ming Article

2005 5

A Yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats
Rejuvenation research, v. 8, (4), 2005, WIN, p. 238-247
Leung, Hoi Yan; Chiu, Po Yee; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference
Life sciences, v. 77, (22), 2005, OCT 14, p. 2770-2782
Du, Ying; Ko, Kam Ming Article
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver
Life sciences, v. 77, (23), 2005, OCT 21, p. 2887-2895
Chiu, PY; Mak, DHF; Poon, MKT; Ko, KM Article
Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells
Molecular and cellular biochemistry, v. 276, (1-2), 2005, AUG, p. 227-234
Ko, Kam Ming; Chiu, Po Yee Article
A "Yang-invigorating" Chinese herbal suppository preparation relieves symptoms in patients with Parkinson's disease
New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005, 2005, p. 243-246
Ko, KM; Chan, K.; Shek, L.; Yeung, J.; Chui, SH Conference paper

2004 7

A Yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects
Phytotherapy research, v. 18, (7), 2004, JUL, p. 525-530
Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Ng, Timothy TL; Chung, YK; Lam, BYH; Du, Ying; Ko, KM Article
Comparing an in vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying herbs
Phytotherapy research, v. 18, (2), 2004, FEB, p. 149-153
Beissenhirtz, Moritz K.; Kwan, Roger Cheuk Hung; Ko, Kam Ming; Renneberg, Reinhard; Scheller, Frieder W.; Lisdat, Fred Article
Pharmacological basis of `Yang-invigoration' in Chinese medicine
Trends in pharmacological sciences, v. 25, (1), 2004, JAN, p. 3-6
Ko, Kam Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat Article
Pharmacological basis of `Yin-nourishing' and `Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb
Life sciences, v. 76, (4), 2004, DEC 10, p. 385-395
Siu, Kai Ming; Mak, Duncan Hon Fai; Chiu, Po Yee; Poon, Michel Kwong Tat; Du, Ying; Ko, KM Article
Processing control of Chinese herbal products: An ultimate approach for quality assurance
Asia-Pacific Biotech News, v. 8, (23), 2004, p. 1338-1341
Ko, Robert Kam Ming; Ng, Ka Ming Article
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats
Molecular and cellular biochemistry, v. 266, (1-2), 2004, NOV, p. 139-144
Chiu, Po Yee; Ko, Kam Ming Article
Deciphering the Myth of Fructus Schisandrae in Traditional Chinese Medicine: Biochemical Basis of its Qi-invigorating Action
Recent Progress in Medicinal Plants Volume 9: Plant Bioactives in Traditional Medicine / J.N. Govil, V.K. Singh, Rajeev Kr. Sharma. Studium Press LLC, 2005, p. 147-163
Ko, K.M.; Chiu, P.Y. Book chapter

2003 10

Challenges in the globalization of Chinese herbal medicine
Asia-Pacific Biotech News., 7:1287-89
Ko, K.M. Article
East meets west in anti-aging medicine
Annal Asia Anti-aging Med. Assoc., 2004:39-44
Ko, K.M. Article
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice
BioFactors, v. 19, (1-2), 2003, p. 33-42
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming Article
Hepatoprotective mechanism of schisandrin B: Role of mitochondrial glutathione antioxidant status and heat shock proteins
FREE RADICAL BIOLOGY AND MEDICINE, v. 35, (4), 2003, AUG 15, p. 368-380
Chiu, Po Yee; Tang, Man Ho; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Metformin protects against carbon tetrachlordie hepatootoxicity in mice: Enhancement of mitochondrial glutathione redox status
Journal of pharmacological sciences, v. 93, (4), 2003, DEC, p. 501-504
Poon, Michel Kwong Tat; Chiu, Po Yee; Mak, Duncan Hon Fai; Ko, Kam Ming Article
Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury
BioFactors, v. 19, (1-2), 2003, p. 43-51
Chiu, Po Yee; Ko, Kam Ming Article
Schisandrin B and other Dibenzocyclooctadiene lignans. In: Herbal Medicines: Molecular Basis in Health & Diseases Management
Marcel Dekker: New York, Basel, Hong Kong / 289-314
Ko, K.M. Book
Anti-aging effects of a Chinese medicine preparation on elderly male subjects
2nd Asia Pacific Conferenece and Exhibition on Anti-Aging Medicine, Singapore, p.73, September
Ko, K.M. Conference paper
Antioxidant potential of a Chinese Medicine Preparation in vitro and in vivo/ex vivo
2nd Asia Pacific Conference and Exhibition on Anti-Aging Medicine 2003, Singapore, p.50, September
Ko, K.M.; Mak, Duncan H.F.; Poon, Michel K.T. Conference paper
Biochemical, immunological, hormonal and anti-oxidant effects of a Chinese Herbal Suppository, Vigconic HY28, on Elderly Male Subjects - An anti-aging solution?
Anti-Aging World Conference, Paris, France, p.105
Chui, Siu Hon; Ko, Kam Ming Conference paper

2002 10

Antioxidant and immunomodulatory activities of Chinese tonifying herbs
Pharmaceutical biology, v. 40, (5), 2002, AUG, p. 329-335
Yim, Tze Kin; Ko, Kam Ming Article
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin
Planta medica, v. 68, (11), 2002, NOV, p. 951-956
Chiu, Po Yee; Mak, Duncan Hon Fai; Poon, Michel Kong Tat; Ko, Kam Ming Article
Protection against carbon tetrachloride liver toxicity by enantiomers of schisandrin B associated with differential changes in hepatic glutathione antioxidant system in mice
Pharmaceutical biology, v. 40, (4), 2002, p. 298-301
Ko, Kam Ming; Poon, Michel Kwong Tat; Ip, Siu Po; Wu, Kim Article
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice
Planta medica, v. 68, (3), 2002, MAR, p. 217-220
Pan, Si Yuan; Han, Yi Fan; Carlier, Paul R.; Pang, Yuan Ping; Mak, Duncan Hon Fai; Lam, Brian Yee Hong; Ko, Kam Ming Article
Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain
Molecular and cellular biochemistry, v. 238, (1-2), 2002, SEP, p. 181-186
Ko, Kam Ming; Lam, Brian Yee Hong Article
Shengmai San
Shengmai San / Edited by Kam-Ming Ko. Taylor & Francis: London, 2002
Ko, Kam Ming Book
Pharmacological studies on Shengmai San
Shengmai San / Editied by Kam-Ming Ko. London: Taylor & Francis, 2002, p. 16-40
Ko, Kam Ming; Mak, Duncan Hon Fai; Yim, Tsz Kin; Yan, Yong Qing Book chapter
A question of quality
Current Drug Discovery, (MAY), 2002, p. 41-42
Ko, Robert Kam Ming Conference paper
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione antioxidant status and induction of heat shock proteins in mice.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p.77
Tang, Man Ho; Chiu, Po Yee; Ko, Kam Ming Conference paper
Time-dependent enhancement in mitochondrial glutathione antioxidant and functional status by schisandrin B treatment decrease the susceptibility of rats hearts to ischemia-reperfusion injury.
2nd International Symposium on Antioxidants in Nutrition & Therapy: Mechanisms in Physiology-Pathology-Pharmacology, Society for Free Radical Research, Bali, Indonesia, October 2-4, p. 75
Chiu, Po Yee; Ko, Kam Ming Conference paper

2001 5

Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants
Japanese journal of pharmacology, v. 85, (4), 2001, APR, p. 435-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Yiu, Ho Yan Article
Effects of Fructus Ligustri Lucidi extracts on concanavalin A-stimulated proliferation of isolated murine splenocytes
Pharmaceutical biology, v. 39, (2), 2001, p. 146-151
Yim, Tze Kin; Ko, Kam Ming Article
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver
Cell stress & chaperones, v. 6, (1), 2001, JAN, p. 44-48
Ip, Siu Po; Che, Chun Tao; Kong, Yun Cheung; Ko, Kam Ming Article
Hepatoprotective action of an oleanolic acid-enriched extract of Ligustrum lucidum fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice
Phytotherapy research, v. 15, (7), 2001, NOV, p. 589-592
Yim, Tze Kin; Wu, WK; Pak, WF; Ko, Kam Ming Article
Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts
Molecular and cellular biochemistry, v. 220, (1-2), 2001, APR, p. 141-147
Ko, Kam Ming; Yiu, Ho Yan Article

2000 3

Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice
Molecular and cellular biochemistry, v. 205, (1-2), 2000, FEB, p. 111-114
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming Article
Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented `Dang-Gui Decoction for Enriching Blood', a compound formulation, ex vivo
Phytotherapy research, v. 14, (3), 2000, MAY, p. 195-199
Yim, Tze Kin; Wu, WK; Pak, WF; Mak, Duncan Hon Fai; Liang, SM; Ko, Kam Ming Article
Schisandrin B protects against menadione-induced hepatotoxicity by enhancing DT-diaphorase activity
Molecular and cellular biochemistry, v. 208, (1-2), 2000, MAY, p. 151-155
Ip, Siu Po; Yiu, Ho Yan; Ko, Kam Ming Article

1999 2

Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats
Biochemical pharmacology, v. 57, (1), 1999, JAN 1, p. 77-81
Yim, Tze Kin; Ko, Kam Ming Article
Schisandrin B protects against myocardial ischemia-reperfusion injury by enhancing myocardial glutathione antioxidant status
Molecular and cellular biochemistry, v. 196, (1-2), 1999, JUN, p. 151-156
Yim, Tze Kin; Ko, Kam Ming Article

1998 3

In vivo antioxidant mechanism of `Sheng Mai San', a compound formulation
Pharmaceutical biology, v. 36, (3), 1998, JUL, p. 189-193
Yick, Pak Kin; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming Article
Myocardial protective effect of an anthraquinone-containing extract of Polygonum multiflorum ex vivo
Planta medica, v. 64, (7), 1998, OCT, p. 607-611
Yim, Tze Kin; Wu, WK; Mak, Duncan Hon Fai; Ko, Kam Ming Article
Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice
ACTA PHARMACOLOGICA SINICA, v. 19, (4), 1998, JUL, p. 313-316
Ip, Siu Po; Che, Chun Tao; Ko, Kam Ming Article

1997 4

Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and Schisandrin B treatment
Molecular and cellular biochemistry, v. 175, (1-2), 1997, OCT, p. 225-232
Mak, Duncan Hon Fai; Ko, Kam Ming Article
Antioxidant activities of Polygonum multiflorum Thunb, in vivo and in vitro
Phytotherapy research, v. 11, (1), 1997, FEB, p. 42-44
Ip, Siu Po; Tse, ASM; Poon, Michel Kwong Tat; Ko, Kam Ming; Ma, CY Article
Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice
Biochemical pharmacology, v. 54, (2), 1997, JUL 15, p. 317-319
Ip, Siu Po; Ma, Cui Ying; Che, Chun Tao; Ko, Kam Ming Article
Protective effect of a lignan-enriched extract of fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy Research, v. 11, (8), 1997, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article

1996 8

Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats
Molecular and cellular biochemistry, v. 162, (2), 1996, SEP 20, p. 153-158
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats
Pharmacology & toxicology, v. 78, (6), 1996, JUN, p. 413-416
Ip, Siu Po; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo
Molecular and cellular biochemistry, v. 165, (2), 1996, DEC 20, p. 161-165
Mak, Duncan Hon Fai; Ip, Siu Po; Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo
Phytomedicine, v. 3, (2), 1996, SEP, p. 217-221
Li, Pui Chun; Mak, Duncan Hon Fai; Poon, Michel Kwong Tat; Ip, Siu Po; Ko, Kam Ming Article
Protective effect of a lignan-enriched extract of Fructus schisandrae on physical exercise induced muscle damage in rats
Phytotherapy research, v. 10, (5), 1996, AUG, p. 450-452
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article
Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats
AMERICAN JOURNAL OF CHINESE MEDICINE, v. 24, (3-4), 1996, p. 255-262
Li, Pui Chun; Poon, Michel Kwong Tat; Ko, Kam Ming Article
Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver
FREE RADICAL BIOLOGY AND MEDICINE, v. 21, (5), 1996, p. 709-712
Ip, Siu Po; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming Article
The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene
Biochemical pharmacology, v. 52, (11), 1996, DEC 13, p. 1687-1693
Ip, Siu Po; Ko, Kam Ming Article

1995 4

Effect of a lignan-enriched fructus Schisandrae extract on hepatic glutathione status in rats: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (2), 1995, APR, p. 134-137
Ko, Kam Ming; Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung Article
Effect of Schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity
Planta medica, v. 61, (5), 1995, OCT, p. 398-401
Ip, Siu Po; Poon, Michel Kwong Tat; Wu, S.S.; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung; Ko, Kam Ming Article
Enhancement of hepatic glutathione regeneration capacity by a lignan-enriched extract of fructus schisandrae in rats
Japanese journal of pharmacology, v. 69, (4), 1995, DEC, p. 439-442
Ko, Kam Ming; Mak, Duncan Hon Fai; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu Po Article
Schisandra Chinensis-derived antioxidant activities in 'Sheng Mai San', a compound formulation, in vivo and in vitro
Phytotherapy research, v. 9, (3), 1995, MAY, p. 203-206
Ko, Kam Ming; Yick, Pak Kin; Poon, Michel Kwong Tat; Che, Chun Tao; Ng, Kam Hung; Kong, Yun Cheung Article

1994 1

Prooxidant and antioxidant effects of trolox on ferric ion-induced oxidation of erythrocyte membrane lipids
Molecular and Cellular Biochemistry, v. 141, (1), p. 65-70
Ko, Kam Ming; Yick, Pak Kin; Poon, Michael K.T.; Ip, Siu Po Article

1993 1

Impaired hepatic antioxidant status in carbon tetrachloride intoxicated rats: An in vivo model for screening herbal extracts with antioxidant activities
Fitoterapia, v. 64, (6), 1993, p. 539-544
Ko, Kam Ming; Yick, Pak Kin; Chiu, Tillie; Hui, T.Y.; Cheng, Christopher Hon Ki; Kong, Yun Cheung Article

1990 1

Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol
Biochemical Pharmacology, v. 40, Issue 4, 15 August 1990, Pages 803-809
Ko, Kam Ming; Godin, David V. Article


No Publications






Teaching Assignment

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2021-22 Winter 1 2021-22 Fall 5 2020-21 Summer 1 2020-21 Spring 7 2020-21 Winter 0 2020-21 Fall 9

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ENTR4904U Student-led Entrepreneurship Acceleration Project


ENTR4903T Student-led Entrepreneurship Acceleration Project
LIFS2720 Biochemistry Laboratory
LIFS4760 Biochemistry of Diseases
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS6114E Current Topics in Biotechnology and Traditional Chinese Medicine


LIFS3510 Junior Research Project I


BIBU4850 Biotechnology and Business Project Research
LIFS2220 Biochemistry II
LIFS3520 Junior Research Project II
LIFS4960 Biological Science Capstone Project
LIFS4961 Biochemistry and Cell Biology Capstone Project
LIFS4981 Biochemistry and Cell Biology Project Research II
LIFS6111N Life Science Postgraduate Student Seminar


BIBU4850 Biotechnology and Business Project Research
BTEC5550 Nutraceuticals and Transgenic Products
LIFS2720 Biochemistry Laboratory
LIFS2820 Biochemical Laboratory Techniques
LIFS4960 Biological Science Capstone Project
LIFS4963 Biotechnology Capstone Project
LIFS4971 Biochemistry and Cell Biology Project Research I
LIFS6114D Current Topics in Biotechnology and Traditional Chinese Medicine
SCIE3500 IRE Research Project I


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 30 January 2022)

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Current RPGs

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Doctor of Philosophy LEUNG, Hoi Yan
Life Science( 2019 - )









ProjectsFrom January 2020 to December 2022

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All Projects 1

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No Projects.
Hong Kong Branch of National Engineering Research Center for Tissue Restoration & Reconstruction


国家人体组织功能重建工程技术研究中心香港分中心 Participating


Innovation and Technology Fund


Project Team (HKUST)
SUN Jianwei (Lead)
CHAU Ying
GUO Zhihong
HSING I-ming
IP Nancy Yuk-Yu
JIA Guocheng
KO Robert Kam Ming
KWOK Ryan Tsz Kin
LAM Wing Yip
LIANG Chun
LIN Nian
LUO Zhengtang
MI Yongli
TSIM Karl Wah Keung
WILLIAMS Ian Duncan
WU Hongkai
WU Zhenguo
YAN Henry He
YAN Yan
YANG Jinglei
YAO Shuhuai


2015 -