Dr.ZHANG, Jiangwen

Associate Professor, School of Biological Sciences, Faculty of Science, HKU

BSc(Wuhan University); MPhil (Johns Hopkins University); PhD (Johns Hopkins University, School of Medicine)

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[javascript protected email address]
2299 0341
2559 9114
KBSB 7N06

Teaching Areas

Omics and Systems Biology
Genetics
Stem cell and Regenerative Biology
From molecules to cells

Research Interests

Cancer
Epigenetics/genetic of cancer
Bioinformatics
Gene regulatory network
Signaling pathways
Cancer omics
Cancer drug development

Current Research

Non-coding RNA in cancer
Chromatin remodeler in cancer
microRNA in cancer
Drug combination against cancer
Cancer gene database
Cancer genetics
Omics tool development

Research Team

Eva Chiu Technician, School of Biological Sciences
Beibei Ru PhD candidate, School of Biological Sciences
Yin Tong PhD candidate, School of Biological Sciences
Qingzheng Kang PhD candidate, School of Biological Sciences
Yunxing Huang PhD candidate, School of Biological Sciences

Publications and News

Ru B*, Sun J*, Kang Q, Tong Y, Zhang J. (2018) A framework for identifying dysregulated chromatin regulators as master regulators in human cancer. Bioinformatics. bty836. (*co-first author)
Chen M, Zhang J, Berger AH, Diolombi MS, Ng C, Fung J, Bronson RT, Castillo-Martin M, Thin TH, Cordon-Cardo C, Plevin R, Pandolfi PP. (2018) Compound haploinsufficiency of DOK2 and DUSP4 cooperates to promote lung tumorigenesis. Journal of Clinical Investigation. (accepted)
Ru B, Tong Y, Zhang J. (2018) MR4Cancer: a web server prioritizing master regulators for cancer. Bioinformatics. bty658
Tong Y*, Sun J*, Wong CF, Kang Q, Ru B, Wong CN, Chan AS, Leung SY, Zhang J. (2018) MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis. Genome Biology. 19:73. (*co-first author)
Tong Y, Ru B, Zhang J. (2018) miRNACancerMAP: an integrative web server inferring miRNA regulation network for cancer. Bioinformatics. bty320.
Ru B, Sun J, Tong Y, Wong CN, Chandra A, Tang ATS, Chow LKY, Wun WL, Levitskaya Z, Zhang J. (2018) CR2Cancer: a database for chromatin regulators in human cancer. Nucleic Acids Research. 46(D1):D918-D924.
Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM, Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB, Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M, Cordon-Cardo C, Pandolfi PP. (2018) An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nature Genetics. 50:206-18.
Bezzi M, Seitzer N, Ishikawa T, Reschke M, Chen M, Wang G, Mitchell C, Ng C, Katon J, Lunardi A, Signoretti S, Clohessy JG, Zhang J, Pandolfi PP. (2018) Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. Nature Medicine. 24:165-75.
Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy J, Berry K, Victor J, Yin Q, Yuan Z, Wei W, Pandolfi PP. (2018) Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nature Communications. 9:159.