Faculty Staff
Dr Li, Xuan

BEng, MMed (SWJTU); PhD (HK)





General Information
Title

Post-doctoral Fellow in Nanomedicine for Oral/Periodontal Care


Division

Periodontology & Implant Dentistry


E-mail

llx815@hku.hk
>


Research profile

HKU Scholars Hub
>


Research Theme

Craniofacial Regeneration




Category
Publications Professional Societies Grants Invited Lectures and Keynote Speeches


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Publications
Article
Chung ACK, Li X, Li WC, Wang T, Lee HK, Jin L, Cai Z, Leung KCF. Mass spectrometry imaging and monitoring of in vivo glutathione-triggered cisplatin release from nanoparticles in the kidneys , Nanoscale Advances 2020; 2: 5857-5865 doi:10.1039/D0NA00708K
WANG C, Cheng T, Li X, Jin L. Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses, Antimicrobial Agents and Chemotherapy 2020; 64(6): article no. e02529-19 doi:10.1128/AAC.02529-19
Li X, Huang R, Tang FK, Li WC, Wong SSW, Leung KCF, Jin L. Red-Emissive Guanylated Polyene-Functionalized Carbon Dots Arm Oral Epithelia against Invasive Fungal Infections, ACS Applied Materials & Interfaces 2019; 11: 46591-46603 doi:10.1021/acsami.9b18003
Leung KCF, Li XB, Li X, Lee SF, Yu JC, Mendes PM, Hermann KE, Van Hove MA. Soft Nanohand Grabs a Growing Nanoparticle, Materials Chemistry Frontiers 2019; 3(8): 1555-1564 doi:10.1039/C9QM00132H
Li X, Li X, Wang S, Leung CFK, Zhang C, Jin L. Infiltration and Profiles of Mesoporous Silica Nanoparticles in Dentinal Tubules, ACS Biomaterials Science & Engineering 2018; 4: 1428-1436 doi:10.1021/acsbiomaterials.7b00919
Lan X, She J, Lin D, Xu Y, Li X, Yang W, Lui VWY, Jin L, Xie X, Su Y. Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy, ACS Applied Materials & Interfaces 2018; 10(39): 33060-33069 doi:10.1021/acsami.8b12926
LI X, Luo W, Ng TC, Leung PC, Zhang C, Leung CFK, Jin L. Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells, Nanoscale 2017; 9: 12897-12907 doi:10.1039/C7NR02546G
Leung KCF, Seneviratne CJ, Li X, Leung PC, Lau CBS, Wong CH, Pang KY, Wong CW, Wat E, Jin L. Synergistic Antibacterial Effects of Nanoparticles Encapsulated with Scutellaria baicalensis and Pure Chlorhexidine on Oral Bacterial Biofilms, Nanomaterials 2016; 6: 61-61 doi:10.3390/nano**
LI X, Pang KY, Ng TW, Leung PC, Zhang C, Leung KCF, Jin L. Cellular Interactions and Formation of an Epithelial “Nanocoating-Like Barrier” with Mesoporous Silica Nanoparticles, Nanomaterials 2016; 6: 192-192 doi:10.3390/nano**
LI X, Wong CH, Ng TW, Zhang C, Leung KCF, Jin L. The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions, International Journal of Nanomedicine 2016; 11: 2471-2471 doi:10.2147/IJN.S105681
Wang Sheng, Guo Lan Ping, Xie Teng, Yang Jian, Tang Jin Fu, Li Xuan, Wang Xiao, Huang Lu Qi. Different secondary metabolic responses to MeJA treatment in shikonin-proficient and shikonin-deficient cell lines from Arnebia euchroma (Royle) Johnst, Plant Cell, Tissue and Organ Culture 2014; 119(3): 587-598 doi:10.1007/s11240-014-0558-5
Seneviratne CJ, Leung CFK, Wong CH, Lee SF, LI X, Leung PC, Lau CBS, Wat E, Jin L. Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms, PLoS ONE 2014; 9: e103234-e103234 doi:10.1371/journal.pone.**
Li Xuan, Yue Hong, Wang Sheng, Huang Lu Qi, Ma Jiong, Guo Lan Ping. Research of different effects on activity of plant antioxidant enzymes, Zhongguo Zhongyao Zazhi 2013; 38(7): 973-978 doi:10.4268/cjcmm**
Guo Lan Ping, Wang Sheng, Zhang Ji, Yang Guang, Zhao Man Xi, Ma Wei Feng, Zhang Xiao Bo, Li Xuan, Han Bang Xing, Chen Nai Fu, Huang Lu Qi. Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism, Science China Life Sciences 2013; 56(11): 1047-1056 doi:10.1007/s11427-013-4562-5
Li Xuan, Wang Sheng, Guo Lanping, Huang Luqi. Effect of cadmium in the soil on growth, secondary metabolites and metal uptake in Salvia miltiorrhiza, Toxicological and Environmental Chemistry 2013; 95(9): 1525-1538 doi:10.1080/**.2014.887717
Li Xuan, Zhao Manxi, Guo Lanping, Huang Luqi. Effect of cadmium on photosynthetic pigments, lipid peroxidation, antioxidants, and artemisinin in hydroponically grown Artemisia annua, Journal of Environmental Sciences (China) 2012; 24(8): 1511-1518 doi:10.1016/S1001-0742(11)60920-0
Wang Sheng, Li Xuan, Jiang Chao, Guo Lan Ping. Advances in studies on genes related to shikonin and its derivatives biosynthesis and signal transduction, Chinese Traditional and Herbal Drugs 2012; 43(6): 1219-1225
Zhou Jie, Fang Lei, Li Xuan, Guo Lanping, Huang Luqi. Jasmonic acid (JA) acts as a signal molecule in LaCl3-induced baicalin synthesis in Scutellaria baicalensis seedlings, Biological Trace Element Research 2012; 148(3): 392-395 doi:10.1007/s12011-012-9379-8
Conference Paper
Wang C, Li X, Cheng T, Jin L. Metronidazole-tolerant Porphyromonas gingivalis persisters dampen cytokine expression in HGECs, Journal of Dental Research (Spec Issue) 2019; 98(Spec Iss A): abstract no. 2313-abstract no. 2313
PG Thesis
Li Xuan Mesoporous silica nanoparticle-encapsulated antimicrobials and Chinese herbal extracts : controlling oral microbes, modulating immuno-inflammatory response & perspectives[PG Thesis]. Pokfulam, Hong Kong: The University of Hong Kong; 2017.

Professional Societies
06/2020-06/2023: MRSC. Royal Society of Chemistry.

Grants
Project Title: A pioneering study on nano-reinforced multifunctional ‘barrier’ of human gingival epithelia loaded with nanoparticles-based antimicrobials and immunoinflammatory modulators
Grant Type: General Research Fund (GRF)
Funding Year: 2018
Amount: HKD**
Principal Investigator: Professor Jin, Lijian
Co-investigator(s): Dr Leung Ken Cham-fai, Dr Li Xuan

Invited Lectures and Keynote Speeches
31 July 2020: Nano-based drug delivery system for oral/periodontal healthcare: An update and perspective. 1st ‘Young Researchers Forum of IADR - Asia Pacific Region’.