中醫內科學、中藥藥理學、神經退行性疾病及心腦血管疾病專家
limin@hkbu.edu.hk
李敏教授，為香港浸會大學中醫藥學院副院長、中醫學學士及生物醫學理學士（榮譽）學位及中醫學碩士學位課程主任及高智明伉儷柏金遜症研究中心主任。李敏教授1985年大學本科畢業獲得醫學學士學位，1988年獲得醫學碩士學位，1998年獲得日中醫學會笹川醫學獎學金留學日本，2001年獲得西醫學博士學位。李敏教授於中國大陸、日本和香港從事中醫臨床、教學和研究工作近三十年，曾先後從師於中國大陸著名中醫專家鄧鐵濤教授、熊繼柏教授。2007年李敏教授獲得由中國中醫藥學會頒發的“全國首屆傑出女中醫師”稱號，2013年獲得香港浸會大學優秀教師獎。李敏教授目前主要從事神經系統退行性疾病包括柏金遜症和阿氏海默症的中醫臨床治療與基礎研究工作。李敏教授的課題組先後開展了中藥複方治療柏金遜症、阿氏海默症的隨機對照雙盲的臨床研究，從中藥中篩選小分子天然自噬誘導劑治療神經退行性疾病的分子藥理研究及治療神經退行性疾病的中藥新藥研發工作。
目前，李敏教授課題組的研究方向為：(1) 中藥複方治療柏金遜症和阿氏海默症的隨機雙盲對照的臨床研究和中西藥合用的相互作用及安全性研究；(2) 中藥複方、提取物和中藥活性組分的神經保護效果和作用機制的研究; (3) 中藥複方、提取物和中藥活性組分保護心腦血管內皮細胞的藥效及作用機理研究。具體資訊可以瀏覽李敏教授的實驗室主頁:http://cpdr.hkbu.edu.hk
精選出版物Google Scholar Citations: 10,192; h-index: 32; i10-index: 83 (July, 2020)
[*, corresponding author(s); †, contribution equally/sharing first authorship]
Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Wang ZY, Cheung KH, Song JX*, Durairajan SSK* & Li M* (2021) “ Qingyangshen mitigates Amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease”. Phytomed. 3 July 2021.doi:10.1016/j.phymed.2021.153648
Tong BCK, Wu JX, Huang SY, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi SK, Sreenivasmurthy SG, Zhu Z, Su CF, Liu J, Song JX, Lu JH, Tan JQ, Pan WD, Li M* & Cheung KH*(2021) “ Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease”. Autophagy. 29 June 2021. doi:10.1080/15548627.2021.1945220
Yang CB, Liu J, Tong BCK, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi SK, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M*(2021) “TFEB, a master regulator of autophagy and biogenesis, unexpected promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2”. Acta Pharmacologica Sinica. 2 June 2021, doi:10.1038 /s41401- 021-00711-7
Wu MY, Cai CZ, Yang CB, Yue ZY, Chen Y, Bian ZX, Li M* & Lu JH* (2021) “Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts”. Neural. Regen. Res. 13 April 2021. doi:10.4103/1673-5374.317973
Su CF, Jiang L, Zhang XW, Iyaswamy A, Li M* (2021) “Resveratrol in Rodent Models of Parkinson’s Disease: A Systematic Review of Experimental Studies”. Frontiers in Pharma. 22 April 2021. doi: 10.3389/fphar.2021.644219
Chen LL, Huang YJ, Yu X, Lu JH, Jia WT, Song JX, Liu LF, Wang YC, Huang YY, Xie JX, Li M*. (2021) Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease. Frontiers in Pharmacology, 2021, 12; 363.
Zheng XY, Jiang YM, Lin WJ, Lu KJ, Wei WJ, Cui SY, Li M, Xu NG, Tang CZ*, Song JX* (2020) “Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of transcription factor EB”, Autophagy. 10 Feb. 2021. doi:10.1080/15548627.2021.1886720
Klionsky DJ, (…), Li M, (…), Lu JH, (…), Song JX, (…), et al. (2021) “Guidelines for the use and interpretation of assays for monitoring autophagy”, Autophagy2021 Jan 2; 17(1):1-382.
Wang ZY#, Liu J#, Zhu Z, Su CF, Sreenivasmurthy SG, Iyaswamy A, Lu JH, Chen G, Song JX, Li M* (2020) “Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: a mechanism review”. Biomedicine & Pharmacotherapy, 133(2021) 110968
Cai CZ#, Yang CB#, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su HX, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue ZY, Li M* & Lu JH.* (2020) “NRBF2 is a Rab7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of Rab7 for degradation”. Autophagy 2020, doi:10.1080/15548627.2020.1760623
Wang XL , Wang CK, Chan HN, Iyaswamy A, Krishnamoorthi SK, Li M, Li HW*, Wong MS*.(2020) “Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation”, Talanta, https://doi.org/10.1016/j.talanta.2020.121830.
Song JX#, Liu J#, Jiang YM, Wang ZY, Li M.* (2020) “Transcription factor EB: An emerging drug target for neurodegenerative disorders”. Drug Discov.Today, doi:10.1016/j.drudis.2020.10.013
Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammella AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY*, Durairajan SSK* & Li M*. (2020) “Yuan-Hu Zhi Tong Prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of Alzheimer’s disease”. Frontiers in Pharmacology, 25 Sept. 2020. doi: 10.3389/fphar.2020.584770, PMID: 584770
Yuen CS, Chua KK, Lau WH, Zhuang ZY, Chow HY, Li M.* (2020) “The effect of conduction exercise and self-acupressure in treatment of Parkinson’s disease: a pilot study”, eCAM. 22 July 2020. Doi:10.1155/2020/7950131 〔IF: 2.064〕
Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M* & Durairajan SSK* (2020) “A mechanistic review on medicinal mushrooms-derived bioactive compounds: potential mycotherapy for alleviating neurological disorders”. Planta Med. 2020 July 14. doi:10.1055/a-1177-4834
Wang SQ, Wang N, Zheng YF, Yang BW, Liu PX, Zhang FX, Li M, Song JX, Chang X, Wang ZY*. (2020) “Caveolin-1 inhibits breast cancer stem cells via c-Myc-mediated metabolic reprogramming”, Cell Death & Disease, 2020 June 11. doi: 10.1038/s41419-020-2667-x
Malampati S, Song JX, Tong BCK, Nalluri A, Yang CB, Wang ZY, Cheung KH, Sreenivasmurthy SG, Zhu Z, Liu J, Krishnamoorthi S, Iyaswamy A, Cheung KH, Lu JH, Li M.* (2020) “Targeting Aggrephagy for the Treatment of Alzheimer’s Disease”. Cells. 2020 Jan 28;9(2):311.doi: 10.3390/cells9020311.
Wu MY, Liu L, Wang EJ, Xiao HT, Cai CZ, Wang J, Su HX, Wang YT, Tan JQ, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M*, Chen Y*, Bian ZX*, Lu JH.* (2020) “PI3KC3 subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation”. Autophagy, 2020 Mar 11. doi: 10.1080/15548627. 2020.1741332. [Epub ahead of print]
Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar S, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH. (2020) “Chronic oral administration of AdipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model”.Mol Psychiatry. 2020 Mar 4. doi: 10.1038/ s41380-020-0701-0.
Ardah MT, Ghanem SS, Abdulla SA, Lv G, Emara MM, Paleologou KE, Vaikath NN, Lu JH, Li M, Vekrellis K, Eliezer D, El-Agnaf OMA. (2020) “Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts”. BMC Complement Med Ther. 2020 Mar 6;20(1):73. doi: 10.1186/s12906-020-2849-1
Wang ZY, Yang CB, Liu J, Tong BCK, Zhu Z, Malampati S, Sreenivasmurthy SG, Cheung KH, Iyaswamy A, Su CF, Lu JH, Song JX *& Li M.* (2020) “A curcumin derivative activates TFEB and protects against Parkinsonian neurotoxicity in vitro”. Inter. J. Mol. Sci. 2020, 21, 1515; doi:10.3390/ijms21041515
Yang CB, Zhu Z, Tong BCT, Iyaswamy A, Xie WJ, Zhu Y, Sreenivasmurthy SG, Senthilkumar K, Cheung KH, Song JX, Zhang HJ, Li M.* (2020) “A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38”. Redox Biology, 2020. Jan 28:101445. doi:10.1016/j.redox.2020.101445.
Liu JY, Liu C, Zhang JF, Zhang YM, Liu KY, Song JX, Sreenivasmurthy SG, Wang ZY, Shi YS, Chu CC, Zhang Y, Wu CS, Deng XH, Liu XY, Song J, Zhuang RQ, Huang SQ, Zhang PF, Li M*, Wen L*, Zhang YW, Liu G.*(2020) “A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease”. ACS Nano, 6 Feb. 2020. DOI: 10.1021/ acsnano.9b06453 Epub 2020 Feb 10. PMID: 32027482
Ji F, Zhu Z, Zhang M, Zhang H, Zhu L, Cai X, Liu W, Song J, Li M*, Cai Z*. (2020) “ 6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat” . Sci Total Environ. 2020 Apr 1;711:135184. doi: 10.1016/j.scitotenv.2019.135184. Epub 2019 Nov 23. PMID: 32000351
Zhuang XX, Wang SF, Tan Y, Song JX, Zhu Z, Wang ZY, Wu MY, Cai CZ, Huang ZJ, Tan JQ, Su HX, Li M, Lu JH*. (2020) “Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models.” Cell Death Dis. 2020 Feb 18;11(2):128. doi: 10.1038/s41419-020-2322-6.
Dong Y, Hu YJ, Li M, Feng D, Song JX, Li M, Medina DL, Tan JQ, Zhang ZH, Sarkar S, Yue ZY, Zong WX, Lu JH*. (2019) “Chemical Autophagy Modulators: a Systematic Review Focusing on Methodology”, Autophagy 2020 Feb;16(2):195-202. doi: 10.1080/15548627.2019.1704119. Epub 2019 Dec 23. PMID: 31841063
Song JX, Malampati S, Zeng Y, Yang CB, Cheung KH, Sreenivasmurthy SG, Wang ZY, Iyaswamy A, Lu JH, Tong BCK, Zhu Z, Shang WB, Tang CT, Xu NG, Li M.* (2019) “A novel TFEB activator ameliorates APP and Tau pathology and improves cognitive deficits in Alzheimer disease transgenic mice”, Aging Cell doi:10.1111/acel.13069
Iyaswamy A, Krishnamoorthi Senthil K, Song JX, Yang CB, Kaliyamoorthy V, Sreenivasmurthy SG, Wang ZY, Malampati S, Durairajan SSK, Li M.*(2020) “ NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-beta and tau pathology in experimental Alzheimer's disease models.” J. Food and Drug Analysis 2020 Jan; 28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. PMID: 31883601
Wang N, Yang BW, Muhetaer G, Wang SQ, Zheng YF, Lu JH, Li M., Zhang FX, Situ HL, Lin Y, Wang ZY*. (2019) “XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy” Biomedicine & Pharmacotherapy 2019 Dec; 120:109519. doi: 10.1016/ j.biopha.2019.109519. Epub 2019 Oct 17. PMID:31629951
Cai CZ,Zhou HF, Yuan NN, Wu MY, Wang SF, Lee MY, Wang YT, Yang CB, Li M, Tan JQ, Lu JH.* (2019) “Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation”, Phytomedicine. 2019, 61. 152842.
Wu AJ, Tong BC, Huang AS, Li M, Cheung KH. (2019) “Mitochondrial calcium signaling as a therapeutic target for Alzheimer's disease ”, Curr Alzheimer Res. 2019 Dec 9. doi: 10.2174/1567210091302. [Epub ahead of print] PMID: 31820698
Naushad M, Durairajan SSD, Bera AK, Senapati S, Li M.* (2019) “Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimer?s Disease”, Planta Med. 2019, 85:1-10.doi:10.1.55/ a-1019-9819 Review. PMID: 31618777
Zheng YF, Liu PX, Wang N, Wang SQ, Yang BW, Li M, Chen JP, Situ HL, Xie MQ, Lin Y, WangZY*(2019) “Betulinic acid suppresses breast cancer metastasis by targeting GRP78-mediated glycolysis and ER stress apoptotic pathway.” Oxidative Med. & Cellular Longevity. 2019 July, Volume 2019, Article ID 8781690, https://doi.org/10.1155/2019/8781690
Wan YP, Lu GH, Zhang JF,* Wang ZY, Li XZ, Chen R, Cui X, Huang ZM, Xiao YF, Chelora J, Zhang WJ, Liu YH, Li M, Xie HY, Lee CS*(2019) “A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy.” Adv. Funct. Mater. 2019 July, 1903436. doi: 10.1002/adfm.201903436
Ji F, Wei J, Luan H, Li M, Cai Z. (2019) “Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics”, Ecotoxicol Environ Saf. 2019 Nov 30; 184:109606. doi: 10.1016/j.ecoenv. 2019. 109606. Epub 2019 Aug 28. PMID: 31472382
Yuen CS, Chua KK, Lau WH, Zhuang ZY, Chow HY, Li M.* (2019) “The effect of conduction exercise and self-acupressure in treatment of Parkinson’s disease: Protocol for a pilot study”, J. Tradi. Chi. Med. Sci. https://doi.org/10.1016/ j.jtcms.2019.07.001.
Ji FF, Sreenivasmurthy SG, Wei J, Shao X, Luan H, Zhu L, Song JX, Liu LF,Li M*, Cai ZW*.(2019) “Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis.” J Hazard Mater. 2019 Jun 6; 378:120738. doi: 10.1016/j.jhazmat. 2019.06.015
Su C, Yang C, Gong M, Ke Y, Yuan P, Wang X,Li M, Zheng X, Feng W.(2019) “Antidiabetic Activity and Potential Mechanism of Amentoflavone in Diabetic Mice”, Molecules. 2019 Jun 11; 24(11). pii: E2184. doi: 10.3390/ molecules 24112184
Yuan NN, Cai CZ, Wu MY, Su HX,Li M, Lu JH.(2019) “Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies.” BMC Complement Altern Med. 2019 May 23;19(1):109. doi: 10.1186/s12906-019-2510-z.
Krishnakumar V, Durairajan SSK*, Alagarasu K, Li M*, Dash AP. (2019) “Recent Updates on Mouse Models for Human Immunodeficiency, Influenza, and Dengue Viral Infections.” Viruses, 2019 Mar 13; 11(3). pii: E252. doi: 10.3390/ v11030252.
Yang B, Wang N, Wang S, Li X, Zheng Y, Li M, Song J, Zhang F, Mei W, Lin Y, Wang Z. (2019) “Network-pharmacology-based identi?cation of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.” Biomed Pharmacother. 2019 Apr; 112:108607. doi: 10.1016/j.biopha.2019.108607. Epub 2019 Feb 20〔Impact Factor: 3.743〕
Zhu Z, Yang CB, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Liu J, Wang ZY, Song JX, Lu JH, Li M.* (2019) “Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease.”, Inter. J. Mol. Sci. 2019 Feb 8;20(3). pii: E728. doi: 10.3390/ijms20030728.
Wang J, Wu MY, Tan JQ, Li M, Lu JH. (2019) “High content screening for drug discovery from traditional Chinese medicine. ” Chin Med. 2019 Feb 28;14:5. doi: 10.1186/s13020-019-0228-y. eCollection 2019.
Krishnakumar V, Durairajan SSK*, Alagarasu K, Li M*, Dash AP. (2019) “Recent Updates on Mouse Models for Pandemic and Epidemic ViralInfections”, Viruses, 2019 Mar 13; 11(3). pii: E252. doi: 10.3390/v11030252.
Yang B, Wang N, Wang S, Li X, Zheng Y, Li M, Song J, Zhang F, Mei W, Lin Y, Wang Z. (2019) “Network-pharmacology-based identi?cation of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis. ”, Biomed Pharmacother. 2019 Apr; 112:108607. doi: 10.1016/j.biopha.2019.108607.
Yuan NN, Cai CZ, Wu MY, Su HX, Li M, Ren JY, Tan JQ, Lu JH.* (2019) “Canthin-6-one accelerates alpha-synuclein degradation by enhancing UPS activity: drug target identification by CRISPR-Cas9 whole genome-wide screening technology”, Front. Pharmacol. 28 January 2019, https://doi.org/ 10.3389/fphar. 2019.00016
Wang ZY, Sravan GS, Song JX, Liu JY*, Li M.*(2018) “Strategies for Brain-targeting Liposomal Delivery of Small Hydrophobic Molecules in the Treatment of Neurodegenerative Diseases”, Drug Discovery Today, Volume 24, Number 2, February 2 , 2019, https://doi.org/10.1016/j.drudis.2018.11.001
Tong BC, Wu AJ, Li M, Cheung KH. (2018) “Calcium signaling in Alzheimer's disease & therapies”, Biochim Biophys Acta Mol Cell Res. 2018 Jul 27. pii: S0167-4889(18)30208-8. doi: 10.1016/j.bbamcr.2018.07.018.
Wang ZY, Wang N, Liu WP, Zhang YF, Wang SQ, Yang BW, Li M, Song JX, Zhang FX, Zhang XT, Wang Q*. (2018) “CXCL1 derived from tumor-associated macrophages promotes breast cancer metastasis via activating NF-κB/SOX4 signaling”, Cell Death and Dis. 2018 Aug 29; 9(9):880. doi: 10.1038/s41419-018-0876-3.
Zhong LL,Cheng CW,Kun W,Dai L,Hu DD,Ning ZW,Xiao HT,Lin CY.,Zhao L,Huang T,Tian K,Chan KH,Lam TW,Chen XR,Wong CT,Li M,Lu AP,Wu JC,Bian ZX.* (2018)“Efficacy of MaZiRenWan, a Chinese Herbal Medicine, in Patients With Functional Constipation in a Randomized Controlled Trial”, Clin Gastroenterol Hepatol.2018 Apr 11. doi: 10.1016/j.cgh.2018.04.005.
Zou J, † Chen ZG,† Liang CQ, † Fu YM, Wei XB, Lu JJ, Pan MQ, Guo Y, Liao XY, Xie HF, Wu DB, Li M, Liang LH,* Wang PH,* Wang Q.* (2018) “Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson’s Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage”. Aging Dis.2018 Feb 1;9(1):51-65. doi: 10.14336/ AD.2017.0416
Yang CB, Cai CZ, Song JX, Tan JQ, Iyaswamy A, Wu MY, Durairajan SSK, Chen LL, Yue ZY, Li M,* & Lu JH.*(2017) “NRBF2 regulates amyloid precursor protein C-terminal fragments (APP-CTFs) degradation via autophagy modulation”, Autophagy 2017;13(12):2028-2040. doi: 10.1080/ 15548627.2017.1379633.
Chen LL, † Wang YB, † Song JX, † Deng WK, Lu JH, Ma LL, Yang CB, Li M,* & Xue Y.* (2017) “Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy”. Autophagy 2017, 13:11, 1969-1980. doi: 10.1080/15548627.2017.1371393
Wu MY, Wang SF, Cai CZ, Tan JQ,Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH.(2017) “Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity”.Oncotarget. 2017 Sep 8;8(44):77673-77684. doi: 10.18632/oncotarget.20767. eCollection 2017 Sep 29.
Lan T.H., Xu D.P., Huang M.T., Song J.X., Wu H.L., Li M. *(2017) “Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF/p38MAPK and SDF-1/CXCR4 activation”. Sci. Rep. 2017 Oct 12;7(1): 13061. doi: 10.1038/s41598-017-13436-7
Wang S.F., Liu L.F., Wu M.Y., Cai C.Z., Su H.X., Tan J.Q., Lu J.H.*, Li M.* (2017) “Baicalein prevents 6-OHDA/Ascorbic acid-induced calcium-dependent dopaminergic neuronal cells death”, Sci. Rep. 2017, 16 August 2017; doi:10.1038/ s41598-017-07142-7
Ji F.F., Luan H.M., Huang Y.Y., Cai Z.W.* & Li M.* (2017) “MS?Based Metabolomics fortheInvestigation ofNeuro?Metabolic Changes Associated withBDE?47 Exposure inC57BL/6 Mice”, J. Anal. Test. 2017, 1:233-244 doi: 10.1007/s41664-017-0026-4
Durairajan S.S.K.*¶, Iyaswamy A¶, Shetty G.S., Kammella A.K., Malampati S., Shang W.B., Yang C.B., Song J.X., Chung S., Huang J.D., Ilango K., Li M.* (2017) “A modified formulation of Huang-lian-Jie-Tu Tang reduces memory impairments and β-Amyloid plaques in a triple transgenic mouse model of Alzheimer’s disease”, Sci. Rep. 2017,7 Articlenumber:6238, doi: 1.1.38/ s41598-017-06217-9
Wang Z.Y., Liu J.Y., Yang C.B., Malampati S. , Huang Y.Y., Li M.X., Li M. * & Song J.X.* (2017) “Neuroprotective natural products for the treatment of Parkinson’s disease by targeting the autophagy-lysosome pathway”, Phytother Res.2017;31(8):1119-1127. doi:10.1002/ptr.5834
Sreenivasmurthy G.S., Liu J.Y., Song J.X., Yang C.B., Malampati S., Wang Z.Y., Huang Y.Y., Li M. * (2017) “Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease”, Int. J. Mol. Sci. 2017 ;18(2). doi: 10.3390/ijms18020272
Durairajan S.S.K.*, Chirasani V.R., Shetty G.S., Iyaswamy A., Malampati S., Song J.X., Liu L.F., Huang J.D., Senapati S., Li M.* (2017) “Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity”, Cur. Alzhei. Res. 2017;14(11):1229-1237. doi: 10.2174/ 1567217103003
Chua K.K., Wong A., Kwan W.L., Song J.X., Chen L.L., Chan L.T., Bian Z.X., Mok V.* & Li M.* (2016) “A Pilot Randomized Controlled Trial of Chinese Medicine (Di-Tan Decoction) in Alzheimer’s disease”. J. Alzheimer Dis. & Parkins. 2017. doi:10.1155/2017/ 1902708
Wang S.F., Cai C.Z., Wu M.Y., Li M.,* Lu J.H.* (2016) “Autophagy modulators from traditional Chinese medicine: mechanisms and therapeutic potentials for cancer and neurodegenerative diseases”, J. Ethnopharma. 2016. doi: 10.1016/ j.jep. 2016.10.069. PMID:27793785
Song J.X., Sun Y.R., Peluso I., Zeng Y., Yu X., Lu J.H., Liu L.F., Xu Z., Wang M.Z., Liu L.F., Huang Y.Y., Chen L.L., Durairajan S.S.K., Zhang H.J., Zhou B., Zhang H.Q., Lu A.P., Ballabio A., Guo Z.H.*, Diego M.,* & Li M.*(2016) “An novel TFEB activator promotes autophagy and lysosomal biogenesis in rat brain independent of mTOR inhibition”. Autophagy 2016; 12(8):1372-89. doi: 10.1080/15548627.2016. .1179404
Tang Z., Liu L.F., Li Y.L., Dong J.Y., Li M., Huang J.D., Lin S.H., Cai Z.W.* (2016) “Urinary Metabolomics Reveals AlterationsofAromatic Amino Acid MetabolismofAlzheimer's Diseasein theTransgenic CRND8 Mice”. Curr. Alzheimer Res. 2016; 13(7):764-76.
Nie S., Chong K., Li M.* (2016) “A study in general education: How a field trip for Chinese tea tasting motivates students’ learning”, Inter.J.Hum. Soc. Sci. & Edu. 2016, 3(1): 125-135.
Klionsky D.J., (…), Li M., (…), Lu J.H., (…), Song J.X., (…), et al. (2016) “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)”. Autophagy2016; 12(1):1-222.
Liu L.F., Song J.X., Lu J.H., Huang Y.Y., Chen L. L., Duriarajan S.S.K., Han Q.B., Li M.* (2015) “Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease”. Sci. Rep. 2015; doi: 10.1038/srep16862.
Friedemann T., Li M.,† Fei J.,† Schumacher U., Song J.X., Schröder S.* (2015)“Hypothesis driven screening of Chinese herbs for promoting neuroprotection”, Special Issue on “The Art and Science of Traditional Medicine” Part3: The Global Impact of Traditional Medicine. Science (Special issue), 2015; S69-71.
Luan H.M., Liu L.F., Tang Z., Mok V. C.T., Li M.,* Cai Z.W.* (2015) “Elevated excretion of biopyrrin as a new marker for idiopathic Parkinson's disease”, ParkinsonismRelat. Disord. 2015; doi: http://dx.doi.org/10.1016/ j. parkreldis. 2015.09.009
Chen L., Song J.X., Luo Y.M., Li M.,* Gao L.* (2015) “Individualized Traditional Chinese Medicine Treatment of Acute Stroke”, Science (Special Issue: Translational Medicine at Capital Medical University: Investigating Major Chronic Disease) 17 July, 2015; P68-71.
Luan H.M., Liu L.F., Tang Z., Zhang M.W., Chua K.K., Song J.X., Mok V. C.T., Li M.,* Cai Z.W.* (2015) “Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson's disease”, Sci. Rep.2015; doi:10.1038/srep13888
Durairajan SSK*, Li M*,Malampatti S, Zhang Y, Huang Y, Liu LF, Song, JX, Chen LL, Zeng Y, Senapati, S. (2015) “Protopine, A promising novel histone deacetylase 6 inhibitor reduces tauopathy in vitroandin vivo”, Neurodegener. Dis. 2015; 15(Suppl. 1): 352-1969-Page1579.
Nie S., Chong K., Thadani R.D., Li M.* (2015) “Lifestyle Changes through Chinese Medicine Education on Health Maintenance and Food Therapy among College Students”, Inter. J. Develop. Res. 2015; 5(6): 4762-4767.
Chua K.K., Wong A., Kwan W.L., Song J.X., Chen L.L., Chan L.T., Lu J.H., Mok V.,* Li M.* (2015) “The efficacy and safety of the Chinese herbal medicine Di-Tan Decoction on Alzheimer’s disease: study protocol for a randomized controlled trial”, Trials 2015, 16:199. DOI: 10.1186/s13063-015-0716-z
Ardah M.T., Paleologou K.E., Lv G.H., Khair S.B.A., Lu J.H., Al-Hayani A.A., Eliezer D., Li M., El-Agnaf O.M.A.*(2015) “Ginsenoside RB1 Inhibits Fibrillation and Toxicity of Alpha-synuclein and Disaggregates Preformed Fibrils”, Neurobiol. of Dis. 2015; 74:89-101.
Gao X.Y., Teng Y.L., Luo J.T., Huang L.G., Li M., Zhang Z.H., Ma Y.C., Ma L.* (2015) “The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions”, RNA Biology 2015; DOI:10.4161/ rna.36100.
Li J.J., Chua K.K., Li M.* (2015) “Constitutional Study of Parkinson’s Disease Patients Based on Traditional Chinese Medicine Pattern Differentiation”, Integra. Med. Inter. 2015; DOI: 10.1159/000369530.
Luan HM,† Liu LF,† Meng N, Tang Z, Chua KK, Chen LL, Song JX, Mok V, Xie LX, Li M,* Cai ZW.* (2015) “LC-MS-based Urinary Metabolite Signatures in Idiopathic Parkinson's Disease”, J. Proteome Res. 2015; 14, 467-478.
Chua KK, Chen LL, Liu LF, Duriarajan SSK, Lu JH, Li M.* (2014) “The Efficacy of Classical Chinese Medicine Formula Di-tan Decoction for Alzheimer’s disease”, Chin. J. Integr. Med. 2014; DOI: 10.1007/s11655-013- 1346.
Zhang XB, Wang L, Li M. (2014) “The Literature Review of Chinese Medicine on the Treatment of Fatty Liver”, Hong Kong J. Tradit. Chin. Med. (Chin.) 2014; 9(4): 75-78.
Mok CT, Chua KK, Lau YK, Chan KW, Chan KH, Tse KP, Chen LL, Man SC, Wong A, Chan A, Bian ZX, Wu J, Li M.* (2014) “Randomized Clinical Trial Evaluating Effects of Traditional Chinese Medicine (Jia-Wei-Liu-Jun-Zi Tang) for Non-motor Symptoms in Parkinson’s Disease”, Mov. Disord. 2014; 29 (Suppl.1): P571
Lu JH, He LQ, Wang QJ, Behrends C, Chait BT, Yamamura K, Friedman SL, Fiel MI, Li M, Yue ZY. (2014) “NRBF2 Regulates Autophagy and Prevents Liver Lesions Through Modulating Beclin 1/Atg
Chen LL, Song JX, Lu JH, Yuan ZW, Liu LF, Duriarajan SSK, Li M.* (2014) “Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-synuclein via Akt/mTOR Pathway”, J. Neuroimmune. Pharma. 2014; 9:380-387.
Durairajan SSK*, Huang YY, Yuen PY, Chen LL, Kwok KY, Liu LF, Song JX, Han QB, Xue L, Chung SK, Huang JD, Baum L, Senapati S, Li M.* (2014)“Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-beta Precursor Protein Processing in Alzheimer's Disease Models ”, PLoS ONE 2014; 3(9): e92954.
Song JX, Lu JH, Liu LF, Chen LL, Durairajan SSK, Yue ZY, Zhang HQ*., Li M. * (2014) “HMGB1 is Involved in Autophagy Inhibition Caused by Alpha-synuclein Overexpression: a Process Modulated by the Natural Autophagy Inducer Corynoxine B”, Autophagy. 2014; 10(1):144-154.
Lin SH, Kanawati B, Liu LF, Witting M., Li M., Huang JD, Schmitt-Kopplin P, Cai ZW. (2014) “Ultrahigh Resolution Mass Spectrometry-based Metabolic Characterization Reveals Cerebellum as a Disturbed Region in Two Animal Models”, Talanta. 2014; 118: 45-53.
Kwok KY, Xu J, Ho HM, Chen HB, Li M, Lang Y, Han QB. (2013)“Quality Evaluation of Commercial Huang-Lian-Jie-Du-Tang based on Simultaneous Determination of Fourteen Major Chemical Constituents using High Performance Liquid Chromatography”, J. Pharm. Biomed. Anal. 2013; 85:239-244.
Chua KK, Gao J, Kum WF, Li M.* (2013) “Impact of Treatment-related Dyskinesias and Non-motor Symptoms on Quality of Life in Chinese Patients with Idiopathic Parkinson’s Disease”, Inter. J. Integra. Med. 2013; DOI: 10. 5772/56777
Si YW, Chua KK, Li M. * (2013) “Literature review of the treatment of Chinese medicine on Motor Symptoms and Non-Symptoms of Parkinson’s disease”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2013; 8(4): 27-29.
Durairajan SSK,* Huang YY, Chen LL, Song JX, Li M.* (2013). “Corynoxine isomers decrease levels of amyloid-beta peptide and amyloid-beta precursor protein by promoting autophagy and lysosome biogenesis”, Mol. Neurodegen. 2013; (Suppl. 1):P16. DOI: 10.1186/1750-1326-8-S1-P16.
Lin SH, Kanawati B, Liu LF, Liu HD, Witting M, Li M., Huang JD, Schmitt-Kopplin P, Cai ZW.* (2013)“Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice”, Anal Bioanal Chem. 2013; 405 (15): 5105-17.
Durairajan SSK*, Chen LL, Song JX, Baum L, Li M.* (2013). “Corynoxine B, a Novel Autophagy Enhancer, Promotes the Clearance of Mutant Tau Aggregation in vitro and in vivo”, Neurodegen. Dis. 2013; Vol. 1, (Suppl.1): P120.
Pung L, Wang XJ, Li M, Xue L. (2013) “The role of APP in Alzheimer’s disease”, Advances in Alzheimer’s Dis. 2013; 2 (2):60-65.
Yuan YM, Li M.* (2013) “Literature review of Chinese medicated diet for hypertension”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2013, 8(2): 66-69.
Li M.* (2013) “The commonly used ten Chinese medicines on the clinical treatment of dementia”, Hong Kong J. Tradit. Chin. Med. (Chin.) 2013; 8(1): 55-58.
Lu JH, Song JX, Durairajan SSK, Liu LF, Li M.* (2012) “Chinese herbal medicinal Corynoxine B promotes the clearance of pathogenic protein aggregations associated with Parkinson’s disease via inducing autophagy”, ACTA Biophysica Sinica. (Suppl.1) 2012; 28(7):21.
Durairajan SSK, Liu LF, Lu JH, Chen LL, Yuan QJ, Chung SK, Huang L, Li XS, Huang JD, Li M.* (2012) “Berberine Ameliorates Beta-amyloid Pathology, Gliosis and Cognitive Impairment in an Alzheimer's Disease Transgenic Mouse Model”, Neurobiol. Aging 2012; 33: 2903-2919.
Lu JH, Tan JQ, Durairajan SSK, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY,* Li M.* (2012) “Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy”, Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.)
Chua KK, Chau CS, Li M.* (2012) “Experimental and clinical research literature review of Tianma Gouteng Yin on the treatment of Parkinson's disease”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2012; 7(4): 66-70.
Chua KK, Li M.* (2012) “Literature Review and Data Analysis of Di-tan Decoction on Experimental and Clinical Study of Dementia”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2012; 7(2): 72-75.
Man SC, Chan KW, Lu JH, Durairajan SSK, Liu LF, Li M. * (2012) “Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia”, Evid. Based Complement. Alternat. Med. 2012; DOI:10.1155/ecam/2012/426215.
Hui ML, Chua KK, Li M.* (2011) “A literature Review on the Treatment of Chinese Medicine in Neurodegenerative Diseases through Supplying Kidney Qi, Promote Blood Circulation and Dispel Phlegm”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2011; 6(4): 35-40.
Liu LF, Durairajan SSK, Lu JH, Koo I, Li M. * (2011) “In Vitro Screening on Amyloid Precursor Protein Modulation of Plants used in Ayurvedic and Traditional Chinese Medicine for Memory Improvement”, J. Ethnopharmacol. 2011; DOI: 10.1016/j.jep.2011.08.065.
Duriarajan SSK, Liu LF, Lu JH, Koo I, Chung SK, Maruyama K, Huang JD, Li M.* (2011) “Beberine Inhibits Abeta Production, Plaque Formation, Gliosis and Cognitive Deterioration in a Transgenic Mouse Model of Alzheimer’s disease”, Neurodegener. Dis. 2011; 8 (Suppl.1), DOI: 10.1159/ 000327701.
Durairajan SSK, Liu LF, Lu JH, Koo I, Maruyama K, Chung SK, Huang JD,* Li M.* (2011) “Stimulation of Non-amyloidogenic Processing of Amyloid Precursor Protein by Cryptotanshinone Involves Activation and Translocation of
Lu JH, Ardah MT, Durairajan SSK, Liu LF, Xie LX, Fong WF, Hasan MY, Huang JD, El-Agnaf MA Omar,* Li M.* (2011) “Baicalein Inhibits Formation of Alpha-synuclein Oligomers within Living Cells and Prevents Abeta Fibrillation and Oligomerization”, ChemBioChem. 2011; 12:615-624.
Kum WF, Durairajan SSK, Bian ZX, Lam YC, Man SC, Xie LX, Lu JH, Huang XZ, Li M.* (2011) “Treatment of Idiopathic Parkinson’s Disease with Traditional Chinese Herbal Medicine: A Randomized Placebo-Controlled Pilot Clinical Study”, Evid. Based Complement. Alternat. Med. 2011; 724353.
Li M. * (2010) “The knowledge of Chinese medicine and its treatment strategies to the dementia”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2010, 5(4): 10-14.
Xie LX, Durairajan SSK, Lu JH, Liu CL, Kum WF, Wu WK, Han D, Liao FL, Huang JD, Li M.* (2010) “The Effect of Salvianolic acid B Combined with Laminar Shear Stress on TNF-alpha stimulated Adhesion Molecule Expression in Human Aortic Endothelial Cells”, Clin. Hemorhe. Mecro. 2010; 44:245-258.
Chan WH, Li M.* (2010) “The Study of the Pathogenesis and Applications of Prescriptions of Palpitation from Ancient Literatures”, Hong Kong J. Tradi. Chin. Med. (Chin.) 2010; 5(2): 16-18.
Chan WS†, Durairajan SSK†, Lu JH, Xie LX, Wang Y, Kum WF, Koo I, Yung KKL, Li M.* (2009) “The Neuroprotective Effects of Astragaloside IV (AS-IV) in 6-OHDA-treated Nigral Primary Cell Culture”, Neurochem. Int. 2009; 55: 414-422.
Kum WF, Gao J, Durairajan SSK, Man SC, Xie LX, Lu JH, Fong WL, Li M.* (2009) “Risk Factors in Development of Motor Complications in Chinese Patients with Idiopathic Parkinson’s disease”, J. Clin. Neurosci. 2009; 16: 1034-1037.
Lam YC, Kum WF, Lu JH, Durairajan SSK, Man SC, Xu M, Zhang XF, Huang XZ, Li M.* (2008) “Efficacy and Safety of Acupuncture for Idiopathic Parkinson’s disease: A Systematic Review”, J. Altern. Complem. Med. 2008; 14(6): 663-671.
Xie LX, Durairajan SSK, Liu CL, Lu JH, Kum WF, Huang JD, Liao FL, Li M.* (2008) “The Effect of Salvianolic Acid B on TNF-a-stimulated Adhesion Molecule Expression under Flow Condition in Endothelial Cells”, Biorheology 2008; 45(1, 2): Suppl.42-43.
Wang Z, Li M, Wu WK, Tan HM, Geng DF. (2008) “Ginsenoside Rb1 Preconditioning Protects against Myocardial Infarction after Regional Ischemia and Reperfusion by Activation of Phosphatidylinositol-3-kinase Signal Transduction”, Cardiovasc Drugs Ther. 2008; 22(6):443-452.
Man SC, Durairajan SSK, Kum WF, Lu JH, Huang JD, Cheng CF, Chung V, Xu M, Li M. * (2008) “Systematic Review of the Efficacy and Safety of Herbal Medicines for Alzheimer’s Disease”, J. Alzheimer’s Dis. 2008; 14(2): 209-223.
Li M*, Zhao MQ, Durairajan SSK, Xie LX, Zhang HX, Kum WF, Goto S, Liao FL. (2008) “Protective Effect of Tetramethylpyrazine and Salvianolic Acid B on Apoptosis of Rat Cerebral Microvascular Endothelial Cell under High Shear Stress”, Clin. Hemorhe. Mecro. 2008; 38:177-187.
Durairajan SSK, Yuan QJ, Xie LX, Chan WS, Kum WF, Koo I, Liu CL, Song YQ, Huang JD.*, Klein WL, Li M.* (2008) “Salvianolic Acid B Inhibits Aβ Fibril Formation, Disaggregates Preformed Fibrils, and Protects Against Aβ-induced Cytotoxicity”, Neurochem. Int. 2008; 52: 741-750.
Zhang HQ, Yau YF, Wong MS, Man OY, He YY, Chan N, Li M. (2008) “Chinese Medicine Formula DSQRL versus Glucocorticoids for the Treatment of Experimental Pulmonary Fibrosis”, J. Ethnopharmacol. 2008; 116: 318-324.
Liu CL, Xie LX, Li M,* Kumar DSS, Goto S, Huang JD.* (2007) “Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling”, PLoS ONE 2007; DOI: 10.1371/ journal.pone.0001321. 2007.12.19
Zhang HQ, Yau YF, Szeto KY, Chan WT, Wong J, Li M. (2007) “Therapeutic Effect of Chinese Medicine Formula DSQRL on Experimental Pulmonary Fibrosis”, J. Ethnopharmacol. 2007; 109: 543-546.
Chung V, Liu L, Bian ZX, Zhao ZZ, Fong WL, Kum WF, Gao J, Li M.* (2006) “The Efficacy and Safety of Herbal Medicines for Idiopathic Parkinson’s Disease: a Systematic Review”, Mov. Disord. 2006; 21: 1709-1715.
Liao FL, Li M, Han D, Cao J, Chen KJ. (2006) “Biomechanopharmacology – a New Borderline Discipline”, Trends. Pharmacol. Sci. 2006; 27:287-289.
Bian ZX, Zhang GS, Wong KL, Hu XG, Liu L, Yang ZJ, Li M. (2006) “Inhibitory Effects of Magnolol on Distal Colon of Guinea Pig in Vitro”, Biol. Pharm. Bull. 2006; 29: 790-795.
Zhao C, Li M, Luo YF, Wu WK. (2006) “Isolation and Structural Characterization of an Immunostimulating Polysaccharide from Fuzi, Aconitum carmichaeli”, Carbohydrate Res. 2006; 341: 485-491.
Leung CY, Liu L, Wong Ricky NS, Zeng YY, Li M, Zhou H. (2005) “Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK and NF-κB transcription factor”, J. Biochem. Biophys. Res. Commun. 2005; 338:1920-1927.
Liao FL, Cao J, Li M, You Y. (2005) “The Methodology in Biomechanopharmacology”, Biorheology 2005; 42: Suppl. 58-59.
Li M,* Zhao MQ, Zhang HX, Goto S, Wu WK, Liao FL. (2005) “Anti-apoptosis Effects of Tetramethylpyrazine and Salvianolic Acid B on Rat Cerebral Microvascular Endothelial Cells under High Shear Stress”, Biorheology 2005; 42: Suppl. 57.
Jiang ZH, Wang JR, Li M, Liu ZQ, Chau KY, Zhao C, Liu L.(2005) “Two Novel Hemiterpene Glucosides with Potent Anti-Platelet Aggregation Activities from Ilex Pubescens”, J. Nat. Prod. 2005; 68: 397-399.
Bian ZX, Liu L, Li M. (2004) “The Treatment of TCM on Post-SARS Syndrome”, J. Trad. Chin. Med. (Chin.) 2004; 45(3):236.
Li M.,* Zhao C., Wong Ricky N.S., Goto S., Wang Z.M., Liao F.L. (2004) “Inhibition of Shear-induced Platelet Aggregation in Rat by Tetramethylpyrazine and Salvianolic acid B”, Clin. Hemorheol. Microcirc.2004; 31:97-103.
Li M,* Wu WK, Liu L, Liao FL, Handa S, Goto S. (2004) “Specific Inhibiting Effects of Ilexonin A on von Willebrand Factor-dependent Platelet Aggregation Under High Shear Rate”, Chin. Med. J.,(Eng.). 2004; 117: 241-246 .
Goto S, Tamura N, Li M, Handa M, Ikeda Y, Handa S, Ruggeri ZM. (2003) “Different Effects of Various Anti-GPIIb-IIIa Agents on Shear-Induced Platelet Activation and Expression of Procoagulant Activity”, J. Thromb. Haemost. 2003; 1: 2022-2030.
Li M,* Liu L, Zhang XH, Yeh ML, Liao FL. (2003) “Correlation between Shear Induced Platelet Aggregation and Viscosity Parameter for Platelet-rich Plasma”, Clin. Hemorheol Microcirc. 2003; 28:259-261.
Li M,* Liao FL, Handa S, Goto S, Liu L. (2002) “Characteristics of the Chinese Herbal Medicines, Ligustrazine Hydrochloride on Platelet Thrombus Formation Occurring Under Flow”, Biorheology 2002; 39: Suppl.463.
Izumi Y, Li M. (2001) “The Initial Exploration of Chinese Medical Diagnosis (II)”. East. Med. (Jap.) 2001; 17: 71-76.
Izumi Y, Li M. (2001) “The Initial Exploration of Chinese Medical Diagnosis (I)”. East. Med. (Jap.) 2001; 16: 73-77.
Izumi Y, Li M. (2001) “The Entrance of Learning Chinese Medicine”. J. Kanagawa Med. Society. (Jap.) 2001; 27:185-192.
Izumi Y, Li M. (2001) “The Chinese Medical Treatment on Neurological Disease”. Clin. Neurosci. (Jap.) 2001; 19: 144-145.
Li M, Handa S, Ikeda Y, Goto S. (2001) “Specific Inhibiting Characteristics of Tetramethylpyrazine, one of the Active Ingredients of the Chinese Herbal Medicine ‘Chuanxiong’, on Platelet Thrombus Formation under High Shear Rates ”, Thromb. Res.2001; 104: 15-28.
Niu XL, Ichimori K, Yang X, Hirota Y, Hoshiai K, Li M, Nakazawa H. (2000) “Tanshinone II-A Inhibits Low Density Lipoprotein Oxidation in Vitro”, Free Radical. Res. 2000; 33:305-312.
Goto S, Ichikawa N, Li M, Goto M, Kim JY, Yoshida M, Ikeda Y, Handa S. (2000) “Platelet Surface P-selectin Molecules Increased after Exposing Platelet to a High Shear Flow”. Inter. Angio. 2000; 19:147-151.
Izumi Y, Li M. (2000) “A Clinical Case Report of Acute Thalamic Dementia Was Treated by Powder of Angelicae Sinensis and Paeoniae”, J. Uni. Guangzhou Trad. Chin. Med. (Chin.) 2000; 17: 358-359.
Li M, Goto S, Sakai H, Kim JY, Ichikawa N, Yoshida M, Ikeda Y, Handa S. (2000) “Enhanced Shear-Induced von Willebrand Factor Binding to Platelets in Acute Myocardial Infarction”, Thromb. Res. 2000; 100:251-261.
Kim JY, Goto S, Sakai H, Ichikawa N, Yoshida M, Li M., Miyuki O., Ikeda Y., Handa S. (1999) “The Effect of Plasma Concentration on Shear-induced von Willebrand Factor-mediated Platelet Aggregation”, Jap. J. Thromb. Haemost. 1999; 10:251-259.
