Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈功教授 (外科学系) |
| Professor VLANTIS Alexander Chris (耳鼻咽喉-头颈外科学系) |
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.mce.2008.12.017 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
其它资讯
摘要Metallothionein (MT) isoforms have not been studied in papillary thyroid cancer. We examined how the functional MTI and MT2 isoforms were expressed in papillary thyroid cancer (KAT5) cells. We demonstrated that KAT5 cells expressed eight functional MT1 and MT2 isoforms induced by cadmium. Elevated calcium and activated ERK1/2 predated MT expression. The inhibition of either calcium or ERK1/2 significantly blocked the isoform expression. The induction of these isoforms accompanied an increased progression of cell cycle from G0/G1 to G2-M. The alternation in cell cycle disappeared when the expression of MT isoforms was blocked by calcium inhibitor or ERK1/2 inhibitor. Collectively, KAT5 cells express eight functional MT1 and MT2 isoforms in a pathway controlled by calcium and ERK1/2. The elevation of the MT isoforms contributes to the decreased G0/G1 but increased G2-M phase. These results reveal a novel pathway for the expression of the functional MT in papillary thyroid cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
着者Liu ZM, van Hasselt CA, Song FZ, Vlantis AC, Cherian MG, Koropatnick J, Chen GG
期刊名称MOLECULAR AND CELLULAR ENDOCRINOLOGY
出版年份2009
月份4
日期10
卷号302
期次1
出版社ELSEVIER IRELAND LTD
页次92 - 98
国际标準期刊号0303-7207
语言英式英语
关键词Cadmium; Calcium; Cell cycle; ERK; Metallothionein; Papillary thyroid cancer
Web of Science 学科类别Cell Biology; CELL BIOLOGY; Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM
