Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| Professor VLANTIS Alexander Chris (耳鼻咽喉-头颈外科学系) |
| 陈功教授 (外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3109/10408360903306384 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/15WOS source URL
其它资讯
摘要Iodine is a key element in the synthesis of thyroid hormones and the process of iodine transport by thyroid cells is active. Iodine deficiency, which is a known risk factor for thyroid cancer, may result from inadequate dietary iodine or from defects in iodine transportation. In contrast, a sufficient supply of iodine can induce cell-cycle arrest and apoptosis in thyroid cancer cells and may prevent the transformation of a differentiated thyroid cancer into a less differentiated or anaplastic form. However, the functions of iodine are complex, and the mechanisms of its action in thyroid cancer are unclear. This review focuses on the role of iodine in the carcinogenesis, proliferation, and apoptosis of thyroid cancers as well as on iodine transporters, most of which are impaired in thyroid cancer. Elucidating the roles of iodine may generate novel diagnostic and therapeutic approaches to thyroid cancer and improve current strategies for its treatment and prevention.
着者Liu XH, Chen GG, Vlantis AC, van Hasselt CA
期刊名称CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
出版年份2009
月份1
日期1
卷号46
期次5-6
出版社Taylor & Francis: STM, Behavioural Science and Public Health Titles
页次302 - 318
国际标準期刊号1040-8363
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1549-781X
语言英式英语
关键词Anti-tumor treatment; apoptosis; carcinogenesis; cell death; iodine; iodine transporters; prevention; proliferation; thyroid cancer
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
