Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 林锡乐教授 (化学系) |
| 区皓智教授 (影像及介入放射学系) |
| Professor Ann Dorothy KING (影像及介入放射学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.ejrad.2004.05.003 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要To determine if proton magnetic resonance spectroscopy (H-1 MRS) of thyroid carcinoma is feasible and to determine if H-1 MRS spectra of malignant tumors differ from that of normal thyroid tissue. We performed H-1 MRS at 1.5 T at echo-times (TE) 136 and 272 ms to examine eight patients with thyroid cancer (primary tumour or nodal metastasis) larger than 1 cm(3) in size and five volunteers with normal thyroids. Spectra acquired from six primary tumors (three anaplastic carcinomas, two papillary carcinomas and one follicular carcinoma) and two nodes (two papillary carcinoma metastases) were analyzed in the time-domain using a non-linear least squares fitting algorithm with incorporation of prior knowledge. Choline (3.2 ppm) was identified in all solid carcinomas with a mean choline/creatine of 4.3 at TE 136 ms and 5.4 at TE 272 ms. Ratios for malignant tumors at TE 136 ms ranged from 1.6 in well differentiated follicular carcinoma to 9.4 in anaplastic carcinoma. No choline was detected in normal thyroid tissues. Our results showed that H-1 MRS is a feasible technique for the evaluation of malignant thyroid tumors larger than I cm 3 and that proton spectra of malignant tumors differ from that of normal thyroid tissue. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
着者King AD, Yeung DKW, Ahuja AT, Tse GMK, Chan ABW, Lam SSL, van Hasselt AC
期刊名称EUROPEAN JOURNAL OF RADIOLOGY
出版年份2005
月份4
日期1
卷号54
期次1
出版社ELSEVIER SCI IRELAND LTD
页次112 - 117
国际标準期刊号0720-048X
语言英式英语
关键词head and neck neoplasms; magnetic resonance (MR); magnetic resonance (MR) tissue characterization; metabolism; spectroscopy; thyroid neoplasms
Web of Science 学科类别Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
