Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 区皓智教授 (影像及介入放射学系) |
| Professor Ann Dorothy KING (影像及介入放射学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1148/radiol.2372041309 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/29WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/37Scopus source URL
其它资讯
摘要PURPOSE: To prospectively evaluate whether proton magnetic resonance (MR) spectroscopy can be used to characterize salivary gland tumors (SGTs). MATERIALS AND METHODS: Ethics committee approval and informed consent were obtained. Hydrogen 1 (1H) MR spectroscopy was performed with echo times of 136 and 272 msec at 1.5 T in both SGTs and normal parotid glands. Spectra were analyzed in the time domain by using prior knowledge in the fitting procedure to obtain peak amplitudes of choline (Cho), creatine (Cr), and unsuppressed water. Mean Cho/Cr and Cho/water ratios for each subgroup of SGTs were obtained, and results were compared by using a nonparametric t test. RESULTS: Successful spectra were acquired in 56 patients (35 men, 21 women; mean age, 56 years) with a total of nine malignant tumors and 47 benign SGTs (24 Warthin tumors, 22 pleomorphic adenomas, one oncocytoma). At an echo time of 136 msec, Cho/Cr ratios were obtained in 26 (47%) of 55 spectra, with a mean value (± standard deviation) of 1.73 ± 0.47, 5.49 ± 1.86, 3.46 ± 0.84, and 2.45 for malignant tumors, Warthin tumors, pleomorphic adenomas, and oncocytoma, respectively. Differences were significant between Warthin tumors and pleomorphic adenomas (P = .028) and between benign SGTs and malignant tumors (P < .001). At an echo time of 272 msec, Cho/Cr ratios were obtained in 16 (30%) of 53 spectra, with a mean value of 2.27 ± 0.69, 6.92 ± 1.47, and 3.67 ± 1.23 for malignant tumors, Warthin tumors, and pleomorphic adenomas, respectively. Differences were also significant between Warthin tumors and pleomorphic adenomas (P = .041) and benign SGTs and malignant tumors (P = .004). There was a significant difference in mean Cho/water ratio for Warthin tumors versus pleomorphic adenomas at echo times of 136 msec (P = .003) and 272 msec (P = .002) but not for benign SGTs versus malignant tumors. CONCLUSION: 1H MR spectroscopy may be used to characterize SGTs, but a larger study is required to validate these initial results. ? RSNA, 2005.
着者King A.D., Yeung D.K.W., Ahuja A.T., Tse G.M.K., Yuen H.Y., Wong K.T., Van Hasselt A.C.
期刊名称RADIOLOGY
出版年份2005
月份11
日期1
卷号2http://aims.cuhk.edu.hk/converis/portal/Publication/37
期次2
出版社Radiological Society of North America
出版地United States
页次563 - 569
国际标準期刊号0033-8419
语言英式英语
