Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 莫树锦教授 (肿瘤学系) |
| 杨明明教授 (肿瘤学系) |
| 黄炜燊教授 (内科及药物治疗学系) |
| 陈力元教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1136/jech.2009.104125 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/26Scopus source URL
其它资讯
摘要Background: Recent epidemiological studies have reported a dose-dependent protective effect of coffee on hepatocellular carcinoma (HCC) with risk reduction ranging from 30% to 80% in daily coffee drinkers compared with non-drinkers. This study examined whether coffee has a similar protective effect when consumed in moderate quantities in chronic hepatitis B virus (HBV) carriers, a group at high risk of developing liver cancer. Methods: A case-control design was employed. 234 HBV chronic carriers (109 cases and 125 controls) were recruited from the Prince of Wales Hospital in Hong Kong from December 2007 to May 2008. Data collection included review of medical records and face-to-face interview. Univariate and multivariate logistic regressions adjusting for age, gender, cigarette smoking, alcohol use, tea consumption and physical activity were conducted with dose-response analysis. Results: Moderate coffee consumption significantly reduced the risk of HCC by almost half (OR 0.54, 95% CI 0.30 to 0.97) with a significant dose-response effect (X2 = 5.41, df = 1, p = 0.02), reducing the risk for moderate drinkers by 59% (OR 0.41, 95% CI 0.19 to 0.89). Conclusion: The findings provided evidence to support the protective effect of coffee consumption in moderate quantities in HBV chronic carriers.
着者Leung W.W.-M., Ho S.C., Chan H.L.Y., Wong V., Yeo W., Mok T.S.K.
期刊名称Journal of Epidemiology and Community Health
详细描述[Epub ahead of print].
出版年份2011
月份6
日期1
卷号65
期次6
出版社British Medical Association
出版地United Kingdom
页次556 - 558
国际标準期刊号0143-005X
电子国际标準期刊号1470-2738
语言英式英语
