Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陶谦教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1182/blood-2009-09-238782 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Using inverse polymerase chain reaction, we identified CD44, located on chromosome 11p13, as a novel translocation partner of IGH in 9 of 114 cases of gastric, nongastric extranodal, follicular, and nodal diffuse large B-cell lymphoma (DLBCL). Notably, these translocations involving IGHS mu were detected in follicular lymphomas and exclusively in germinal center B cell-like (GCB)-DLBCLs. CD44 is notexpressed in reactive GC B cells. The IGHS mu/CD44 translocations substitute S mu for the CD44 promoter and remove exon 1 of CD44, resulting in the overexpression of I mu-CD44 hybrid mRNA transcripts activated from derivative 11 that encode a new CD44 variant lacking the leader peptide and with a unique C-terminus (CD44 Delta Ex1). When overexpressed in vitro in the CD44(-) GCB-DLBCL cell line BJAB, CD44 Delta Ex1-green fluorescent protein localized to the cytoplasm and nucleus, whereas CD44s-green fluorescent protein (standard form) localized to the plasma membrane. The ectopic expression of CD44 Delta Ex1 in BJAB cells enhanced their proliferation rate and clonogenic ability, indicating a possible pathogenic role of the translocation. (Blood. 2010;115:2458-24http://aims.cuhk.edu.hk/converis/portal/Publication/61)
着者Hu XT, Chen YW, Liang ACT, Au WY, Wong KY, Wan TSK, Wong MLY, Shen LJ, Chan KK, Guo TH, Chu KM, Tao Q, Chim CS, Loong F, Choi WWL, Lu LW, So CC, Chan LC, Kwong YL, Liang RHS, Srivastava G
期刊名称Blood
出版年份2010
月份3
日期25
卷号115
期次12
出版社AMER SOC HEMATOLOGY
页次2458 - 24http://aims.cuhk.edu.hk/converis/portal/Publication/61
国际标準期刊号000http://aims.cuhk.edu.hk/converis/portal/Publication/6-4971
电子国际标準期刊号1528-0020
语言英式英语
Web of Science 学科类别Hematology; HEMATOLOGY
