Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁承晖教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.ultrasmedbio.2007.02.009 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/28WOS source URL
其它资讯
摘要Fibrosis is a common late effect of radiotherapy treatment for cancer patients. Current clinical assessment of radiation-induced fibrosis is generally limited to clinician-based rating scales, which are usually not sufficient for quantitative and objective evaluations. Ultrasonic propagation properties of tissues are widely reported to be sensitive to the alterations of tissue compositions and structures. Based on our previous feasibility study, we used four parameters including skin thickness and three ultrasonic parameters of dermal tissues (attenuation slope [beta], integrated attenuation [IA] and integrated backscatter [IBS]) in the frequency range of 10 to 25 MHz for the assessment of skin fibrosis. Experiments were conducted on the forearm and neck skin in patients with postirradiation fibrosis in the neck region. The palpation score and stiffness of the neck soft tissue were also measured as an indication of fibrotic severity. Comparisons of the results between 38 patients and 20 control subjects showed a significantly smaller beta (p = 0.005) and a significantly larger skin thickness (p < 0.004) and IA (p = 0.04) in the neck skins of the patients. However, age-matched comparisons showed there were neither significant differences among patient subgroups with different fibrotic levels assessed using manual palpation or significant correlations between the four parameters and the overall stiffness of the neck soft tissues (p > 0.05). In conclusion, ultrasound tissue characterization may provide additional information for the assessment of postirradiation skin fibrosis in the neck region. Further studies are necessary to investigate the feasibility of applying the current measurement for differentiating the severity of skin fibrosis.
着者Huang YP, Zheng YP, Leung SF, Choi APC
期刊名称Ultrasound in Medicine and Biology
出版年份2007
月份8
日期1
卷号33
期次8
出版社ELSEVIER SCIENCE INC
页次1191 - 1198
国际标準期刊号0301-5629
电子国际标準期刊号1879-291X
语言英式英语
关键词attenuation; backscatter; fibrosis; hand palpation; nasopharyngeal carcinoma (NPC); radiotherapy; skin; soft tissue; ultrasound; ultrasound indentation
Web of Science 学科类别Acoustics; ACOUSTICS; Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
