Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 郭汉龙博士 (生物医学学院) |
| 郑彦铭教授 (内科及药物治疗学系) |
| 徐宗宪博士 (肿瘤学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/4WOS source URL
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摘要We have previously demonstrated the possible growth inhibitory activity of both first generation of the effective microorganism fermentation extract (EM-X) as well as the second generation (EM-X2) on cancer cell lines in vitro. The possible anti-angiogenic potential of EM-X has not been reported. Herein we show that using the concentrated EM-X, the growth of human umbilical cord endothelial cells (HUGE) was significantly inhibited in vitro. Enzyme linked immunosorbent assay suggested that the concentrated EM-X is able to reduce the level of vascular endothelial growth factor (VEGF) from Hep3B hepatocellular carcinoma (HCC) cells. The conditioned culture medium obtained from the concentrated EM-X incubated Hep3B HCC cells possessed significant antiproliferative effect on the HUCE cells. Moreover, in vivo chick chorioallantoic membrane assay further demon-strated that the concentrated EM-X is able to greatly inhibit the basic fibroblast growth factor induced angiogenesis from chick embryo experiment. We speculate that the anti-cancer potential of this concentrated EM-X involved growth inhibition on cancer cell and antiangiogenic effect on HUCE cells.
着者Chui CH, Gambari R, Lau FY, Hau DKP, Wong RSM, Cheng GYM, Kok SHL, Higa T, Ke B, Chan ASC, Fong DWF, Tang JCO
期刊名称International Journal of Molecular Medicine
出版年份2006
月份11
日期1
卷号18
期次5
出版社PROFESSOR D A SPANDIDOS
页次975 - 979
国际标準期刊号1107-3756
电子国际标準期刊号1791-2http://aims.cuhk.edu.hk/converis/portal/Publication/4http://aims.cuhk.edu.hk/converis/portal/Publication/4X
语言英式英语
关键词chick chorioallantoic membrane; effective microorganism fermentation extract; human umbilical cord endothelial cell
Web of Science 学科类别Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
