Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陶谦教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.2741/2000 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/71WOS source URL
其它资讯
摘要Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.
着者Tao Q, Young LS, Woodman CB, Murray PG
期刊名称Frontiers in Bioscience
出版年份2006
月份9
日期1
卷号11
出版社FRONTIERS IN BIOSCIENCE INC
页次2672 - 2http://aims.cuhk.edu.hk/converis/portal/Publication/713
国际标準期刊号1093-9946
语言英式英语
关键词apoptosis; carcinoma; CpG; EBV; Epstein-Barr virus; herpesvirus; immortalization; immunosuppression; latent; lymphoma; lytic; methylation; nasopharyngeal; persistence; promoter; review; therapy; transformation
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY
