Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 赖宝山教授 (外科学系) |
| 郑彦铭教授 (内科及药物治疗学系) |
| 徐宗宪博士 (肿瘤学系) |
| 郭汉龙博士 (生物医学学院) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/2WOS source URL
其它资讯
摘要Novel drug discovery research for anti-cancer purposes remains urgent and essential, since cancer is still a major fatal cause disease in the http://aims.cuhk.edu.hk/converis/portal/Publication/21st century. Cantharidin is a highly toxic compound especially affecting the haematopoietic and renal systems. it can be purified from some naturally occurring insects, including Mylabris species. Here we review our experience in the chemical synthesis and biological screening of five chemically modified cantharidin analogues on a series of human carcinoma cell lines. The pollination between chemical and bio-medical concepts during pharmaceutical design is encouraging in the discovery of novel compounds by maintaining the anti-cancer action, and simultaneously showing the selectivity on non-malignant cells.
着者Kok SHL, Gambari R, Chui CH, Lam WS, Chen J, Lau FY, Wong RSM, Cheng GYM, Lai PBS, Leung TWT, Chan ASC, Tang JCO
期刊名称Minerva Biotecnologica
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2006
月份9
日期1
卷号18
期次3
出版社EDIZIONI MINERVA MEDICA
页次153 - 157
国际标準期刊号11http://aims.cuhk.edu.hk/converis/portal/Publication/20-48http://aims.cuhk.edu.hk/converis/portal/Publication/26
语言英式英语
关键词cantharidin; neoplasms; structural activity relationship
Web of Science 学科类别Biotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY
