Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈德章教授 (肿瘤学系) |
| Professor Radha RAGHUPATHY (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.2741/2000 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/71WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/74Scopus source URL
其它资讯
摘要Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.
着者Tao Q., Young L.S., Woodman C.B.J., Murray P.G.
期刊名称Frontiers in Bioscience
出版年份2006
月份6
日期6
卷号11
期次SUPPL. 2
出版社Frontiers in Bioscience
出版地United States
页次2672 - 2http://aims.cuhk.edu.hk/converis/portal/Publication/713
国际标準期刊号1093-9946
语言英式英语
关键词Apoptosis, Carcinoma, CpG, EBV, Epstein-Barr virus, Herpesvirus, Immortalization, Immunosuppression, Latent, Lymphoma, Lytic, Methylation, Nasopharyngeal, Persistence, Promoter, Review, Therapy, Transformation
