Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 庄立信教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1034/j.1600-0676.2001.021002143.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/14WOS source URL
其它资讯
摘要Background/Aims: Recent reports of an association between human leucocyte antigens (HLA) and persistence of hepatitis B virus infection, and the familial clustering of hepatocellular carcinoma raise the question of genetic susceptibility Previous studies have been limited to serological phenotyping of HLA B and DR antigens. The aim of this study was to use molecular genotyping to investigate HLA class II as a risk factor for the development of hepatocellular wt-cinema in Hong Kong Chinese. Methods. We determined HLA DRB1, DQA1, DQB1 and DPB1 alleles in 123 hepatitis B surface antigen positive patients (84 with hepatocellular carcinoma and 39 without) and 124 matched controls. Results: The alleles DRB1*1501 (36% of HCC patients ver sus 19% of controls, odds ratio = 2.44), DQA1*0.102 (42% versus 76%, odds ratio=2.07), and DPB1*0501 (80% versus 63%, odds rsttio-2.35) were significantly more common in patients with hepatocellular carcinoma, and DQA1*03 (36% versus 56%, odds ratio=0.53), DQB1*0302 (4.% versus 13%, odds ratio=0.25) and DPB1*0201 (http://aims.cuhk.edu.hk/converis/portal/Publication/14% versus 29%, odds ratio=0.4) were found at significantly lower frequencies. Conclusions: Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted.
着者Donaldson PT, Ho S, Williams R, Johnson PJ
期刊名称LIVER
出版年份2001
月份4
日期1
卷号21
期次2
出版社BLACKWELL MUNKSGAARD
页次http://aims.cuhk.edu.hk/converis/portal/Publication/143 - http://aims.cuhk.edu.hk/converis/portal/Publication/148
国际标準期刊号0106-9543
语言英式英语
关键词genetic associations, susceptibility; hepatitis B virus (HBV); hepatocellular carcinoma (HCC); Hong Kong Chinese, susceptibility; human leucocyte antigens (HLA)
Web of Science 学科类别Gastroenterology & Hepatology
