Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 姚凯诗教授 (药剂学院) |
| 陈基湘教授 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.jval.2016.09.384 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Objectives
Most people in Hong Kong are infected by varicella zoster virus (VZV) in childhood. The risk of herpes zoster (HZ) upon VZV reactivation increases with age. Lifetime risk of HZ is significantly age-related, affecting mainly those aged ≥5http://aims.cuhk.edu.hk/converis/portal/Publication/0 years old, as a result of waned cell-mediated immunity. With an aging population in Hong Kong, it is anticipated that the HZ incidence will increase over time. We aimed to describe the patient characteristics, clinical and economic outcomes of hospitalized herpes zoster.
Methods
A retrospective, observational study was conducted in a Hong Kong teaching hospital. Hospitalized patients aged ≥18 years with HZ as primary discharge diagnosis during year 2http://aims.cuhk.edu.hk/converis/portal/Publication/011-2http://aims.cuhk.edu.hk/converis/portal/Publication/012 (prior to zoster vaccine available in Hong Kong) were included. Treatment outcomes included HZ-related length of hospital stay (LOS), cost of treatment, and HZ-related complications.
Results
We reviewed 1http://aims.cuhk.edu.hk/converis/portal/Publication/08 HZ cases (45.4% male and mean age 66±16 yeas) and 34 (31%) were immunocompromised patients. Median LOS was 6 days (IQR 3-9) days. HZ-associated complications occurred in 42 (38.9%) cases, with 16 cases (14.8%) of post-herpetic neuralgia. Median treatment cost was HKD29,http://aims.cuhk.edu.hk/converis/portal/Publication/094 (IQR HKD15,http://aims.cuhk.edu.hk/converis/portal/Publication/07http://aims.cuhk.edu.hk/converis/portal/Publication/0-43,842) (USD1=HKD7.8). In multivariate analysis, underlying malignancy was associated with prolonged LOS (OR=6.http://aims.cuhk.edu.hk/converis/portal/Publication/05; 95% CI 1.22-3http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/02; p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/028) and high treatment cost (OR=1http://aims.cuhk.edu.hk/converis/portal/Publication/0.6http://aims.cuhk.edu.hk/converis/portal/Publication/0; 95% CI 1.29-86.89; p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/028). Immune diseases increased risk of HZ-associated complications (OR=3.55; 95%CI 1.2http://aims.cuhk.edu.hk/converis/portal/Publication/0-1http://aims.cuhk.edu.hk/converis/portal/Publication/0.5http://aims.cuhk.edu.hk/converis/portal/Publication/0; p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/022). In immunocompetent patients (n=74), age >7http://aims.cuhk.edu.hk/converis/portal/Publication/0 years was associated with prolonged LOS (OR=3.25; 95% Cl 1.23-8.55; p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/017) and high treatment cost (OR=3.47; 95% Cl 1.32-9.http://aims.cuhk.edu.hk/converis/portal/Publication/08; p=http://aims.cuhk.edu.hk/converis/portal/Publication/0.http://aims.cuhk.edu.hk/converis/portal/Publication/011).
Conclusions
HZ-associated hospitalization, occurred most commonly in elderly, caused substantial economic burden and high complication rate. Underlying immune diseases were associated with increased risk of HZ-related complications in hospitalized HZ patients.
出版社接受日期http://aims.cuhk.edu.hk/converis/portal/Publication/01.11.2http://aims.cuhk.edu.hk/converis/portal/Publication/016
着者Yu Wing Yin, Chan Kay Sheung Paul, YOU Hoi-sze Joyce
会议名称ISPOR 19th Annual European Congress
会议开始日29.1http://aims.cuhk.edu.hk/converis/portal/Publication/0.2http://aims.cuhk.edu.hk/converis/portal/Publication/016
会议完结日http://aims.cuhk.edu.hk/converis/portal/Publication/02.11.2http://aims.cuhk.edu.hk/converis/portal/Publication/016
会议地点Vienna
会议国家奥地利
会议论文集题名Value in Health
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份11
卷号19
期次7
页次A413 - A413
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/098-3http://aims.cuhk.edu.hk/converis/portal/Publication/015
语言美式英语
