Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林革教授 (生物医学学院) |
| 潘松昇先生 (药剂学院) |
| 杜健华教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.dib.2016.02.064 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/1Scopus source URL
其它资讯
摘要We have recently reported that vatalanib, an orally active small molecule multi-tyrosine kinase inhibitor (Hess-Stumpp et al., 2005 [http://aims.cuhk.edu.hk/converis/portal/Publication/1]), can sensitize multidrug resistant (MDR) colon cancer cells to chemotherapy under hypoxia by inhibiting two MDR transporters ABCBhttp://aims.cuhk.edu.hk/converis/portal/Publication/1 and ABCG2 (To et al., 20http://aims.cuhk.edu.hk/converis/portal/Publication/15 [2]). This data article describes the possible circumvention of resistance to specifically platinum (Pt)-based anticancer drugs by vatalanib via inhibition of two other efflux transporters ABCC2 and ATP7A. Data from the flow cytometric transporter efflux assay showed specific inhibition of ABCC2 activity by vatalanib in stable transfected cells and ABCC2-overexpressing oxaliplatin-resistant colon cancer cells HCThttp://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/16/Oxa. We also performed the transporter ABCC2 ATPase assay and showed an increase in ATP hydrolysis by ABCC2 in the presence of vatalanib. ATP7A mRNA expression was also shown to be upregulated in HCThttp://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/16/Oxa cells. Vatalanib was shown to suppress this upregulated ATP7A expression. Data from the cellular Pt accumulation assay showed a lower Pt accumulation in HCThttp://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/16/Oxa cells than the parental sensitive HCThttp://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/16 cells. Vatalanib was shown to increase cellular Pt accumulation in a concentration-dependent manner. Combination of oxaliplatin and vatalanib was shown to restore the suppressed apoptosis in HCThttp://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/16/Oxa cells.
着者To K.K.W., Poon D.C., Wei Y., Wang F., Lin G., Fu L.-W.
期刊名称Data in Brief
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/16
月份6
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号7
出版社Elsevier BV
出版地Netherlands
页次437 - 444
国际标準期刊号2352-3409
语言英式英语
关键词Chemoresistance, Oxaliplatin, Platinum drugs, Tyrosine kinase inhibitor, Vatalanib
