Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/2$@○○ |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/2WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/2Scopus source URL
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摘要In a recent genome-wide association study (GWAS) of symptomatic epilepsy in the Chinese population, the most significant single nucleotide polymorphism (SNP) allele was rshttp://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/29http://aims.cuhk.edu.hk/converis/portal/Publication/2096 [G] (P=1.0×10-8, odds ratio [OR]=0.63), in the CAMSAP1L1 gene (also known as CAMSAPhttp://aims.cuhk.edu.hk/converis/portal/Publication/2). Here, we report that rshttp://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/29http://aims.cuhk.edu.hk/converis/portal/Publication/2096 genotypes tended to associate with expression of CAMSAP1L1 RNA in the temporal lobe (p=0.054) and hippocampus (p=0.http://aims.cuhk.edu.hk/converis/portal/Publication/20) of epilepsy surgery patients, with expression tending to increase with the G allele. CAMSAP1L1 and β-tubulin double immunofluorescence exhibited partial overlap. CAMSAP1L1 siRNA transfection of human SH-SY5Y neuroblastoma cells treated with or without retinoic acid reduced the CAMSAP1L1 protein level nearly 60% and stimulated neurite outgrowth, as measured by total length, number of processes and number of branches. Therefore, the rshttp://aims.cuhk.edu.hk/converis/portal/Publication/2http://aims.cuhk.edu.hk/converis/portal/Publication/29http://aims.cuhk.edu.hk/converis/portal/Publication/2096 G allele of CAMSAP1L1, which was associated with reduced risk of symptomatic epilepsy, tended to associate with increased expression of CAMSAP1L1, which represses neurite outgrowth. Greater neurite growth in response to brain insults might increase formation of ectopic neural circuits and thus the risk of epileptogenesis. ? http://aims.cuhk.edu.hk/converis/portal/Publication/2013 Elsevier Ireland Ltd.
着者Zhang S., Kwan P., Baum L.
期刊名称Neuroscience Letters
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2013
月份11
日期http://aims.cuhk.edu.hk/converis/portal/Publication/27
卷号556
出版社Elsevier BV
出版地Netherlands
页次146 - 151
国际标準期刊号0304-3940
电子国际标準期刊号187http://aims.cuhk.edu.hk/converis/portal/Publication/2-797http://aims.cuhk.edu.hk/converis/portal/Publication/2
语言英式英语
关键词CAMSAP1L1, CAMSAPhttp://aims.cuhk.edu.hk/converis/portal/Publication/2, Epileptogenesis, Neurites, Symptomatic epilepsy
