Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周柽森教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1592/phco.19.10.832.31564 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
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摘要We evaluated the antifibrillatory effect of two different doses of amiodarone after cardiac arrest with a cardiopulmonary resuscitation (CPR) model in 19 pigs. Ventricular fibrillation was induced by pacing the right ventricle using a primary drive train at a cycle length of 270 msec for 8 beats. The minimum current strength necessary to induce sustained ventricular fibrillation was defined as the ventricular fibrillation threshold (VFT) measured in mA. Three VFT determinations were made at baseline,followed by 9 minutes of continuous CPR with two determinations of VFT, aria three after stabilization. The pigs were placed into one of three groups: amiodarone 2 or http://aims.cuhk.edu.hk/converis/portal/Publication/5 mg/kg, or placebo. The average poststabilization VFT in each group was compared with the average baseline VFT. Pigs receiving amiodarone 2 mg/kg had significantly higher VFT after stabilization than at baseline (22.88 +/- 12.76 to 27.10 +/- 10.18 mA, p = 0.048), as did those receiving http://aims.cuhk.edu.hk/converis/portal/Publication/5 mg/kg (17.03 +/- 7.01 to 28.08 +/- 11.http://aims.cuhk.edu.hk/converis/portal/Publication/58 mA, p = 0.002). The Delta VFT was significantly greater with amiodarone http://aims.cuhk.edu.hk/converis/portal/Publication/5 mg/kg than with vehicle (placebo), but not with 2 mg/kg. There were no changes in VFT in any group during CPR versus baseline. When active treatments were combined, the trend was toward better survival in the amiodarone groups (13/13) compared with the placebo group (4/6, p = 0.076).
着者Chen BP, White CM, Fan C, Kluger J, Chow MSS
期刊名称Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
出版年份1999
月份7
日期1
卷号19
期次7
出版社PHARMACOTHERAPY PUBLICATIONS INC
页次832 - 837
国际标準期刊号0277-0008
电子国际标準期刊号187http://aims.cuhk.edu.hk/converis/portal/Publication/5-9114
语言英式英语
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
