Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 何淑珊博士 (药剂学院) |
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0378-5173(98)00199-9 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
其它资讯
摘要An in-liquid drying microencapsulation method for producing sustained release cefaclor (CF) microspheres has been developed. Sieved fractions of CF monohydrate particles together with polyvinylpyrrolidone (M-w similar to 40 000) were dispersed in a solvent mixture of dichloromethane with cyclohexane (40:60 v/v) containing dissolved ethylcellulose (EC; 4http://aims.cuhk.edu.hk/converis/portal/Publication/8-49.5% ethoxy content). Encapsulation was effected by adding the dispersion to a stirred aqueous medium saturated with CF. The resulting microspheres (collected overnight and oven-dried at 40 degrees C) were examined for size and surface features by scanning electron microscopy, and for solid-state interactions and phase changes using differential scanning calorimetry (DSC), thermogravimetric analysis and powder X-ray diffractometry. The rate and extent of CF release in aqueous medium was measured at 37 degrees C using the USP rotating basket method at 100 rpm. The size, degree of sphericity, and rate of CF release of the microspheres were all shown to depend on the CF to EC mass ratio and the stirring speed employed in encapsulation. Higher EC to CF mass ratio and lower stirring speed afforded microspheres with slower release rate of CF. The rate of CF release from the microspheres fit the simplified Higuchi's planar model equation, and for the samples prepared at various EC:CF ratios, exhibited a strong correlation with drug loading (r =0.9http://aims.cuhk.edu.hk/converis/portal/Publication/8; n=4 (mean values); p <0.05). DSC studies on the samples indicated an absence of molecular interactions between EC and CF in the microspheres. The results demonstrate that the in-liquid drying method, if appropriately optimized, could be used to produce sustained-release CF microspheres with the desired release pattern and physical properties. (C) 199http://aims.cuhk.edu.hk/converis/portal/Publication/8 Elsevier Science B.V. All rights reserved.
着者Chow AHL, Ho SSS, Tong HHY, Ma HHM
期刊名称International Journal of Pharmaceutics
出版年份199http://aims.cuhk.edu.hk/converis/portal/Publication/8
月份10
日期15
卷号172
期次1-2
出版社ELSEVIER SCIENCE BV
页次113 - 125
国际标準期刊号037http://aims.cuhk.edu.hk/converis/portal/Publication/8-5173
电子国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/873-3476
语言英式英语
关键词cefaclor-ethylcellulose microspheres; drug-polymer ratio; in-liquid drying microencapsulation; stirring speed; sustained release
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
