Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
| 陆颖菲女士 (矫形外科及创伤学系) |
| 张锦芳教授 (矫形外科及创伤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.yexcr.2015.03.027 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. (C) 2015 Elsevier Inc. All rights reserved.
着者Lu YF, Zhang L, Waye MMY, Fu WM, Zhang JF
期刊名称Experimental Cell Research
详细描述To ORKTS: doi: 10.10http://aims.cuhk.edu.hk/converis/portal/Publication/16/j.yexcr.2015.03.027
出版年份2015
月份5
日期15
卷号334
期次1
出版社Elsevier
页次173 - 182
国际标準期刊号0014-4827
电子国际标準期刊号1090-2422
语言英式英语
关键词Metastasis; miR-218; Target genes; Tumorigenesis
Web of Science 学科类别Cell Biology; Oncology
