Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 王毅翔教授 (影像及介入放射学系) |
| 区皓智教授 (影像及介入放射学系) |
| 秦岭教授 (矫形外科及创伤学系) |
| 蔡继洲博士 (那打素护理学院) |
| Professor James Francis GRIFFITH (影像及介入放射学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s00330-008-1219-z |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Peripheral quantitative CT (pQCT) is the main method of bone mineral density (BMD) measurement in small animals. However, pQCT is usually only available in specialized centers, while clinical multidetector computed tomography (MDCT) is much more widely available. This study investigated the feasibility of using clinical http://aims.cuhk.edu.hk/converis/portal/Publication/64-slice MDCT for measuring the BMD of rat lumbar vertebrae. The lumbar vertebrae of 18 7-month-old female Sprague-Dawley rats were studied. Two MDCT protocols (General Electric LightSpeed), comprising single 2.5-mm and continuous 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm acquisitions, and a single pQCT protocol (Scanco Densiscan 2000), comprising 1-mm acquisitions, were performed. The following comparisons were carried out: 2.5-mm MDCT densitometry versus 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm MDCT densitometry; 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm MDCT densitometry compared to pQCT densitometry; same day repeatability of 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm MDCT densitometry; longitudinal repeatability of 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm MDCT densitometry on day 0 and day 28 and longitudinal 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm MDCT densitometry in ovariectomized rats on day 0 and day 28. Comparisons were made using intra-class correlation coefficient (ICC). Examination time per animal was 5 min for MDCT and 30 min for pQCT. Acquisitions of 2.5-mm MDCT had a larger coefficient of variation (CoV) than 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm acquisitions. MDCT densitometry had good agreement with pQCT densitometry (ICC = 0.85). Same-day MDCT densitometry with 0.http://aims.cuhk.edu.hk/converis/portal/Publication/625-mm acquisitions had a small CoV (1.http://aims.cuhk.edu.hk/converis/portal/Publication/61%). MDCT densitometry of non-ovariectomized animals at 28 days showed no BMD change, while MDCT densitometry of ovariectomized animals showed a 13.7 +/- http://aims.cuhk.edu.hk/converis/portal/Publication/6.7% BMD reduction at 28 days. Clinical MDCT can reliably and accurately measure rat lumbar vertebral BMD and is much faster than pQCT.
着者Wang YXJ, Griffith JF, Zhou H, Choi KC, Hung VWY, Yeung DKW, Qin L, Ahuja AT
期刊名称European Radiology
出版年份2009
月份4
日期1
卷号19
期次4
出版社Springer Verlag (Germany)
页次882 - 890
国际标準期刊号0938-7994
电子国际标準期刊号1432-1084
语言英式英语
关键词Bone mineral density; Peripheral quantitative computed tomography (pQCT); Quantitative computed tomography; Rat; Vertebra
Web of Science 学科类别Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
