Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁秉中教授 (中医中药研究所) |
| 梁国穗教授 (矫形外科及创伤学系) |
| 区皓智教授 (影像及介入放射学系) |
| 郭志锐教授 (内科及药物治疗学系) |
| 蔡继洲博士 (那打素护理学院) |
| Professor James Francis GRIFFITH (影像及介入放射学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1359/JBMR.080233 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/81WOS source URL
其它资讯
摘要A link between bone blood flow and osteoporosis may exist. Outside of the spine, the proximal femur is the most common site of osteoporotic fracture and is also an area prone to avascular necrosis and fracture nonunion. This study of the proximal femur investigates the relationship between BMD, bone marrow fat content, bone perfusion, and muscle perfusion. One hundred twenty healthy female subjects (mean age, 74 yr; age range, 67-89 yr) underwent DXA examination of the hip, proton MR spectroscopy, and dynamic contrast-enhanced MR imaging of the right proximal femur, acetabulum, and adductor thigh muscle. In all bone areas examined (femoral head, femoral neck, femoral shaft, acetabulum), perfusion indices (maximum enhancement, enhancement slope) were significantly reduced in subjects with osteoporosis compared with subjects with osteopenia or normal BMD. Adductor muscle perfusion was not affected by change in BMD. As marrow perfusion decreased in the proximal femur, marrow fat increased (r = 0.827). This increase in fat content seemed to account for the decrease in marrow perfusion more than a reduction in BMD. For normal BMD subjects, perfusion parameters in the femoral head were one third of those in the femoral neck or shaft and one fifth of those in the acetabulum. Perfusion throughout the proximal femur is reduced in osteoporotic subjects compared with osteopenic and normal subjects. This reduction in perfusion only affects bone and not those tissues outside of bone with the same blood supply. As bone perfusion decreased, there was a corresponding increase in marrow fat.
着者Griffith JF, Yeung DKW, Tsang PH, Choi KC, Kwok TCY, Ahuja AT, Leung KS, Leung PC
期刊名称Journal of Bone and Mineral Research
出版年份2008
月份7
日期1
卷号23
期次7
出版社AMER SOC BONE & MINERAL RES
页次1068 - 1075
国际标準期刊号0884-0431
电子国际标準期刊号1523-46http://aims.cuhk.edu.hk/converis/portal/Publication/81
语言英式英语
关键词blood flow; femur; magnetic resonance imaging; marrow fat; osteoporosis
Web of Science 学科类别Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM
