Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 张丽群博士 (那打素护理学院) |
| 陈基湘教授 (微生物学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/63WOS source URL
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摘要Human papillomavirus (HPV) type 58 has been found to be prevalent among Chinese patients with cervical cancer. This study examined the oncogenic risk of HPV58 variants in Hong Kong, a southern part of China. Altogether, 1924 women were studied: 42.8% with a normal cervix, 16.2% with cervical intraepithelial neoplasia (CIN) I, 12.7% with CIN II, 20.8% with CIN III, and 7.6% with invasive cervical cancer (ICC). The overall prevalence of HPV58 was 11.4% (220) and increased statistically significantly with the severity of neoplasia (p(trend)<.001, X 2 test for trend). Among HPV58-positive women, the occurrence of E7 http://aims.cuhk.edu.hk/converis/portal/Publication/632C-->T J20I) and E7 760G-->A (Ghttp://aims.cuhk.edu.hk/converis/portal/Publication/63S) variants (T20I/Ghttp://aims.cuhk.edu.hk/converis/portal/Publication/63S) showed a positive trend of association with the severity of neoplasia (P-trend<.001, χ(2) test for trend). HPV58 variants carrying these two substitutions showed an odds ratio (OR) for ICC of 26.79 (95% confidence interval = 10.14 to 74.72), and this OR was 6.9-fold higher than the ORs of variants without these substitutions. Patients with CIN III or ICC who were also infected with T20I/Ghttp://aims.cuhk.edu.hk/converis/portal/Publication/63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P =.038, two-sided Mann-Whitney U test). Thus, HPV58 variants carrying E7 T20I/Ghttp://aims.cuhk.edu.hk/converis/portal/Publication/63S substitutions may be associated with an increased risk for cervical cancer.
着者Chan PKS, Lam CW, Cheung TH, Li WWH, Lo WK, Chan MYM, Cheung JLK, Cheng AF
会议名称18th International Papillomavirus Conference
会议开始日01.07.2000
会议地点BARCELONA
期刊名称JOURNAL OF THE NATIONAL CANCER INSTITUTE
出版年份2002
月份8
日期21
卷号94
期次16
出版社OXFORD UNIV PRESS INC
页次1249 - 1253
国际标準期刊号0027-8874
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
