Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
| 李卓予教授 (生物医学学院) |
| 徐国荣教授 (生物医学学院) |
| 冯国培教授 (生物医学学院) |
| 陈活?教授 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/jcb.1244 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/26WOS source URL
其它资讯
摘要Elfin (previously named CLIM1) is a protein that possesses an N-terminal PDZ domain and a C-terminal LIM domain. It belongs to the family of Enigma proteins. Enigma proteins are a family of cytoplasmic proteins that contain an N-terminal PDZ domain and a series of C-terminal LIM domains. By virtue of these two protein interacting domains, Enigma proteins are capable of protein-protein interactions. It has been proposed that Enigma proteins may act as adapters between kinases and the cytoskeleton. We have previously shown that Elfin is most abundantly expressed in the heart and it colocalizes with alpha -actinin 2 at the Z-disks of the myocardium. In this report, Elfin was shown to localize at the actin stress fibers of myoblasts, as revealed by green fluorescent protein (GFP) tagging. In situ hybridization and immunostaining showed that Elfin expression begins at an early stage in mouse development and is present throughout the developing heart. Taken together, our experimental results suggest that Elfin may play an important role in myofibrillogenesis and heart development. J. Cell. Biochem. 83: 463-472, 2001. (C) 2001 Wiley-Liss, Inc.
着者Kotaka M, Lau YM, Cheung KK, Lee SMY, Li HY, Chan WY, Fung KP, Lee CY, Waye MMY, Tsui SKW
期刊名称Journal of Cellular Biochemistry
出版年份2001
月份1
日期1
卷号83
期次3
出版社WILEY-LISS
页次463 - 472
国际标準期刊号0730-2312
电子国际标準期刊号1097-4644
语言英式英语
关键词CLIM1; CLP-36; embryonic development; enigma protein; heart muscle; LIM domain; PDZ domain
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Cell Biology; CELL BIOLOGY
