Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
| 李卓予教授 (生物医学学院) |
| 冯国培教授 (生物医学学院) |
| 徐国荣教授 (生物医学学院) |
| 曾丽玲小姐 (生物医学学院) |
| 许陈小章教授 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1006/bbrc.2000.2454 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/22WOS source URL
其它资讯
摘要We have previously reported an association of 14-3-3 epsilon isoform with calmodulin. Using the voltage-clamp technique, the present study investigated the potential role of 14-3-3 in modulating the Ca2+-activated Cl- channel (CaCC) endogenously expressed in Xenopus oocytes. Injection of 14-3-3 epsilon antisense oligodeoxynucleotides resulted in potentiation of the ionomycin-induced Cl- current, while 14-3-3 peptide and calmodulin inhibitor, W13, suppressed the antisense-potentiated current. The data suggest that 14-3-3 epsilon plays an inhibitory role in modulating the CaCC by interacting with the calmodulin-dependent pathway. The potential role of 14-3-3 epsilon in other tissues and its therapeutic potential for cystic fibrosis are discussed. (C) 2000 Academic Press.
着者Chan HC, Wu WL, So SC, Chung YW, Tsang LL, Wang XF, Yan YC, Luk SCW, Siu SS, Tsui SKW, Fung KP, Lee CY, Waye MMY
期刊名称Biochemical and Biophysical Research Communications
出版年份2000
月份4
日期13
卷号270
期次2
出版社ACADEMIC PRESS INC
页次581 - 587
国际标準期刊号0006-291X
电子国际标準期刊号1090-2104
语言英式英语
关键词14.3.3; calcium activated chloride channel; calmodulin; human; Xenopus
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS
