Doubly adaptive biased coin designs with delayed responses
Publication in refereed journal


香港中文大学研究人员 ( 现职)

陈伟森教授 (金融学系)

张绍洪教授 (统计学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1002/cjs.5550360404

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/15WOS source URL

其它资讯

摘要In clinical studies, patients are usually accrued sequentially. Response-adaptive designs are then useful tools for assigning treatments to incoming patients as a function of the treatment responses observed thus far. In this regard, doubly adaptive biased coin designs have advantageous properties under the assumption that their responses can be obtained immediately after testing. However, it is a common occurrence that responses are observed only after a certain period of time. The authors examine the effect of delayed responses on doubly adaptive biased coin designs and derive some of their asymptotic properties. It turns out that these designs are relatively insensitive to delayed responses under widely satisfied conditions. This is illustrated with a simulation study.

着者Hu FF, Zhang LX, Cheung SH, Chan WS
期刊名称Canadian Journal of Statistics
出版年份2008
月份12
日期1
卷号36
期次4
出版社Wiley: 12 months
页次541 - 559
国际标準期刊号0319-5724
电子国际标準期刊号1708-945X
语言英式英语

关键词Adaptive design; asymptotic normality; biased coin design; clinical trial; response-adaptive design; strong consistency; variance estimation
Web of Science 学科类别Mathematics; Statistics & Probability; STATISTICS & PROBABILITY