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Effects of refractoriness variation on the interpulse interval statistics at the output of the neuro

香港中文大学 辅仁网/2017-06-23

Effects of refractoriness variation on the interpulse interval statistics at the output of the neuromuscular junction
Publication in refereed journal


香港中文大学研究人员 ( 现职)
张元亭教授 (电子工程学系)


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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/2WOS source URL

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摘要The variation in refractory period of muscle fibers has not been studied systematically in electromyography (EMG) forward modeling, although changes in cell excitability are observed experimentally in some myopathies. The effect of the absolute refractory period variation at the postmembrane of a neuromuscular junction is theoretically analyzed in this work for the input stimulus with exponentially and normally distributed interpulse intervals (IPIs). Mathematical expressions on the probability density function (p.d.f.) of the output IPIs are carried out for both cases. The comparison is made between the theoretical and simulated results of output IPI probabilities and mean firing rate for different values of absolute refractory period. It has been demonstrated that the theoretical results are consistent with simulated ones. The output mean firing rates will be reduced when increasing the value of absolute refractory period at the postmembrane for exponential cases, while for Gaussian cases, it will keep almost unchanged at first, then decrease dramatically with the continuous increasing of the absolute refractory period. The results of this work may provide an aid in understanding clinical surface EMG for certain muscle diseases.

着者Hu XL, Zhang YT
期刊名称Electromagnetics
出版年份http://aims.cuhk.edu.hk/converis/portal/Publication/2001
月份10
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/21
期次7-8
出版社TAYLOR & FRANCIS LTD
页次531 - 543
国际标準期刊号0http://aims.cuhk.edu.hk/converis/portal/Publication/27http://aims.cuhk.edu.hk/converis/portal/Publication/2-6343
语言英式英语

关键词firing statistics; linear system model; rate coding; refractoriness variation; surface electromyography
Web of Science 学科类别Engineering; Engineering, Electrical & Electronic; ENGINEERING, ELECTRICAL & ELECTRONIC

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