Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 关海山教授 (生命科学学院) |
| 农文燕先生 (生命科学学院) |
| 张文杰先生 (食品研究中心) |
| 黄丹丹女士 (食品研究中心) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/nar/gks1264 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/27WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/30Scopus source URL
其它资讯
摘要In bacteria, small regulatory non-coding RNAs (sRNAs) are the most abundant class of post-transcriptional regulators. They are involved in diverse processes including quorum sensing, stress response, virulence and carbon metabolism. Recent developments in high-throughput techniques, such as genomic tiling arrays and RNA-Seq, have allowed efficient detection and characterization of bacterial sRNAs. However, a comprehensive repository to host sRNAs and their annotations is not available. Existing databases suffer from a limited number of bacterial species or sRNAs included. In addition, these databases do not have tools to integrate or analyse high-throughput sequencing data. Here, we have developed BSRD (http://kwanlab.bio.cuhk.edu. hk/BSRD), a comprehensive bacterial sRNAs database, as a repository for published bacterial sRNA sequences with annotations and expression profiles. BSRD contains over nine times more experimentally validated sRNAs than any other available databases. BSRD also provides combinatorial regulatory networks of transcription factors and sRNAs with their common targets. We have built and implemented in BSRD a novel RNA-Seq analysis platform, sRNADeep, to characterize sRNAs in large-scale transcriptome sequencing projects. We will update BSRD regularly. ? The Author(s) 2012.
着者Li L., Huang D., Cheung M.K., Nong W., Huang Q., Kwan H.S.
期刊名称Nucleic Acids Research
出版年份2013
月份1
日期1
卷号41
期次D1
出版社Oxford University Press
出版地United Kingdom
国际标準期刊号0http://aims.cuhk.edu.hk/converis/portal/Publication/305-1048
电子国际标準期刊号1362-4962
语言英式英语
