Sunlight exposure and breast density: A population-based study
Publication in refereed journal


香港中文大学研究人员 ( 现职)

古毓君女士 (赛马会公共卫生及基层医疗学院)

秦岭教授 (矫形外科及创伤学系)

阮伯仁先生 (体育部)

胡令芳教授 (内科及药物治疗学系)

林子平教授 (矫形外科及创伤学系)

苏金凤女士 (外科学系)

陈雪鹦教授 (赛马会公共卫生及基层医疗学院)

全文

数位物件识别号 (DOI) ○○@1○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○$@○○

引用次数
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Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/3Scopus source URL

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摘要Purpose: This study aims to assess the association of sunlight exposure with breast cancer risk, measured by the breast density assessed from Tabár's mammographic pattern in Chinese women. Methods: A total of 676 premenopausal women were recruited to participate in this study, in which 650 completed a validated sunlight exposure questionnaire via telephone. The mammograms were classified according to Tabár's classification for parenchyma, and patterns IV & V and I, II & III indicated respectively high and low risk mammographic patterns for breast cancer. The odds ratios (OR) and 95% confidence intervals (CIs) for sun exposure-related variables were estimated using unconditional logistic regression with adjustment for potential confounders. Results: Among 646 participants, women with high breast cancer risk (Tabár's patterns IV &V) had less hours spent in the sun than those with low risk (I, II & III) at any age stage. A higher level of sunlight exposure was associated with a significantly lower risk having high risk Tabár's pattern. Women aged 40 to 44 years who were in the highest tertile of lifetime total hours spent in the sun had a multi-adjusted OR of 0.41 (95% CI, 0.18-0.9○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○; p for trend=0.0http://aims.cuhk.edu.hk/converis/portal/Publication/3) compared with those in the lowest tertile (>○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○.19 hr/day vs. <1.http://aims.cuhk.edu.hk/converis/portal/Publication/3○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○ hr/day). For hours spent in the sun across the ages of 6 to 1○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○ years, the comparable OR was 0.http://aims.cuhk.edu.hk/converis/portal/Publication/37 (95% CI, 0.15-0.91; p for trend=0.0http://aims.cuhk.edu.hk/converis/portal/Publication/3). Conclusion: These findings suggest that higher sunlight exposure is related to a lower risk of having high risk breast density pattern in premenopausal women. Our results also suggest the most relevant period of exposure is during earlier life. ? ○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○01http://aims.cuhk.edu.hk/converis/portal/Publication/3 Korean Breast Cancer Society. All rights reserved.

着者Wu S.-H., Ho S.C., So E., Lam T.-p., Woo J., Yuen P.Y., Qin L., Ku S.
期刊名称Journal of Breast Cancer
出版年份○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○01http://aims.cuhk.edu.hk/converis/portal/Publication/3
月份6
日期1
卷号16
期次○○@1http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○
出版社Korean Breast Cancer Society
出版地South Korea
页次171 - 177
国际标準期刊号17http://aims.cuhk.edu.hk/converis/portal/Publication/38-6756
语言英式英语

关键词Breast neoplasms, Mammographic density, Sunlight, Vitamin D