Prolonged profound hypotension complicating severe methyldopa overdose
Publication in refereed journal


香港中文大学研究人员 ( 现职)

陈恩强教授 (内科及药物治疗学系)

Professor Gavin Matthew JOYNT (麻醉及深切治疗学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.5414/CP202031

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL

其它资讯

摘要Objective: Methyldopa, a centrally acting antihypertensive drug, has been in use since the 196http://aims.cuhk.edu.hk/converis/portal/Publication/0s, but reports of (severe) overdose are rare. We present a case of severe methyldopa overdose with prolonged profound hypotension. Case summary: A 5http://aims.cuhk.edu.hk/converis/portal/Publication/0-year-old woman developed sinus bradycardia, prolonged profound hypotension, and drowsiness after ingesting over 3http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0 tablets (>75 g) of methyldopa. At presentation, her blood pressure was 59/27 mmHg, heart rate 49 beats/minute, and Glasgow Coma Scale Score 14. She needed intensive care unit (ICU) care and intravenous infusion of a large amount of fluids and Gelofusine (R), injections of ephedrine sulphate, and intravenous infusion of norepinephrine for 41 hours followed by dopamine for 21 hours to maintain her systolic blood pressure at similar to 1http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0 mmHg. She was observed for 3 more days in the general ward before discharge. Conclusion: Severe methyldopa overdose can be complicated by prolonged profound hypotension. The management of these patients should include close monitoring of vital functions and administration of intravenous fluids, colloids, and vasopressor agents.

着者Chan TYK, Joynt GM
期刊名称International Journal of Clinical Pharmacology and Therapeutics
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/014
月份7
日期1
卷号52
期次7
出版社DUSTRI-VERLAG DR KARL FEISTLE
页次628 - 63http://aims.cuhk.edu.hk/converis/portal/Publication/0
国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/0946-1965
语言英式英语

关键词bradycardia; drowsiness; hypotension; methyldopa; vasopressors
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY