Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 曹之宪教授 (生物医学学院) |
| 于君教授 (内科及药物治疗学系) |
| 黄静雯小姐 (生物医学学院) |
| 于利博士 (生物医学学院) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/gt.2012.22 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/14Scopus source URL
其它资讯
摘要Cathelicidin is a pleiotropic host defense peptide secreted by epithelial and immune cells. Whether endogenous cathelicidin is protective against ulcerative colitis, however, is unclear. Here we sought to delineate the role of endogenous murine cathelicidin (mCRAMP) and the therapeutic efficacy of intrarectal administration of mCRAMP-encoding plasmid in ulcerative colitis using dextran sulfate sodium (DSS)-challenged cathelicidin-knockout (Cnlp -/-) mice as a model. Cnlp-/- mice had more severe symptoms and mucosal disruption than the wild-type mice in response to DSS challenge. The tissue levels of interleukin-1β and tumor necrosis factor-α, myeloperoxidase activity and the number of apoptotic cells were increased in the colon of DSS-challenged Cnlp-/- mice. Moreover, mucus secretion and mucin gene expression were impaired in Cnlp-/- mice. All these abnormalities were reversed by the intrarectal administration of mCRAMP or mCRAMP-encoding plasmid. Taken together, endogenous cathelicidin may protect against ulcerative colitis through modulation of inflammation and mucus secretion. ? 20http://aims.cuhk.edu.hk/converis/portal/Publication/13 Macmillan Publishers Limited All rights reserved.
着者Tai E.K.K., Wu W.K.K., Wang X.J., Wong H.P.S., Yu L., Li Z.J., Lee C.W., Wong C.C.M., Yu J., Sung J.J.Y., Gallo R.L., Cho C.H.
期刊名称GENE THERAPY
详细描述To ORKTS: Updated this record and deleted duplication (Phttp://aims.cuhk.edu.hk/converis/portal/Publication/133544) on 24-Feb-2015.
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/13
月份2
日期1
卷号20
期次2
出版社Nature Publishing Group
出版地United Kingdom
页次187 - 193
国际标準期刊号0969-7128
语言英式英语
关键词Antimicrobial peptide, Cathelicidin, IL-1, Mucin, TNF, Ulcerative colitis
