Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 吴兆文教授 (外科学系) |
| 于君教授 (内科及药物治疗学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 吴宗华博士 (内科及药物治疗学系) |
| 胡嘉麒教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/bjc.2011.57 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/62WOS source URL
其它资讯
摘要Recent researches have shed light on the biological importance of microRNAs (miRNAs) in colorectal cancer (CRC) genesis, progression and response to treatments. The potential utility of miRNAs in the preclinical stage have been explored and investigated. In this review, we explored the literature and reviewed the cutting edge progress in the discovery of noninvasive plasma and faecal miRNAs for CRC early diagnosis, as well as their measurability and predictability. We also discussed the utility of miRNAs as novel prognostic and predictive markers, and their association with CRC clinical phenotypes including recurrence, metastasis and therapeutic outcomes. Finally, we summarised miRNA- related single- nucleotide polymorphisms and their potential influence on sporadic CRC susceptibility and therapeutic response. In conclusion, the use of miRNAs as biomarker for CRC is still in its infancy and need further characterisation and evaluation. British Journal of Cancer (2011) 104, 893- 898. doi: 10.1038/bjc.2011.57www.bjcancer. com
着者Dong Y, Wu WKK, Wu CW, Sung JJY, Yu J, Ng SSM
期刊名称British Journal of Cancer
出版年份2011
月份3
日期15
卷号104
期次6
出版社NATURE PUBLISHING GROUP
页次893 - 898
国际标準期刊号0007-0920
电子国际标準期刊号1532-1827
语言英式英语
关键词colorectal cancer; diagnostic marker; miRNA; prognostic marker; single-nucleotide polymorphisms
Web of Science 学科类别Oncology; ONCOLOGY
