Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Tony GIN (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/jac/47.4.421 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/92WOS source URL
其它资讯
摘要The aim of this study was to determine the pharmacokinetic profile of the normal recommended dose of ceftriaxone in critically ill patients and to establish whether the current daily dosing recommendation maintains plasma concentrations adequate for antibacterial efficacy. Ceftriaxone at a recommended dose of 2 g iv was administered od to 12 critically ill patients with severe sepsis and normal serum creatinine concentrations. Blood samples were taken at predetermined intervals over the first 24 h and on day 3 for measurement of ceftriaxone concentrations. There was wide variability in drug disposition, explained by the presence of variable renal function and identified by the measurement of creatinine clearance. In nine patients with normal renal function, there was a high level of creatinine clearance(mean +/- S.D., 41 +/- 12 mL/min) and volume of distribution (20 +/- 3.3 L), which resulted in an elimination half-life of 6.4 +/- 1.1 h. In comparison with normal subjects, ceftriaxone clearance was increased 100%, volume of distribution increased 90% and the elimination half-life was similar. Three patients had substantially suboptimal plasma ceftriaxone concentrations. We confirm previous findings that ceftriaxone clearance in critically ill patients correlates with renal clearance by glomerular filtration. The elimination half-life is prolonged (21.4 +/- 9.8 h) in critically ill patients with renal failure when compared with previously published data in non-critically ill patients with renal failure. We conclude that in critically ill patients with normal renal function, inadequate plasma concentrations may result following od bolus dosing of ceftriaxone. Drug accumulation may occur in critically ill patients with renal failure.
着者Joynt GM, Lipman J, Gomersall CD, Young RJ, Wong ELY, Gin T
期刊名称Journal of Antimicrobial Chemotherapy
出版年份2001
月份4
日期1
卷号47
期次4
出版社OXFORD UNIV PRESS
页次421 - 429
国际标準期刊号0305-7453
电子国际标準期刊号1460-2091
语言英式英语
Web of Science 学科类别Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
