Publication in refereed journal
香港中文大学研究人员 ( 现职)
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/jac/43.2.309 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/78WOS source URL
其它资讯
摘要We randomized 18 critically ill patients to receive ceftazidime 6 g/day by continuous infusion or bolus dosing (2 g 8 hourly), each with a loading dose of 12 mg/kg ceftazidime. During the first 8 h, plasma ceftazidime concentration fell below 40 mg/L in only one patient (trough 38 mg/L) from the infusion group, compared with eight from the bolus group (2-33 mg/L) for periods ranging from 73 to 369 min. Thereafter all infusion patients; remained above 40 mg/L for 40 h of study versus 20-30% of bolus patients. The pharmacokinetic and pharmacodynamic characteristics of ceftazidime suggest that continuous infusions should be clinically investigated in outcome studies.
着者Lipman J, Gomersall CD, Gin T, Joynt GM, Young RJ
期刊名称Journal of Antimicrobial Chemotherapy
出版年份1999
月份2
日期1
卷号43
期次2
出版社OXFORD UNIV PRESS
页次309 - 311
国际标準期刊号0305-7453
电子国际标準期刊号1460-2091
语言英式英语
Web of Science 学科类别Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
