Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1177/096032719601500313 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/17WOS source URL
其它资讯
摘要Potassium permanganate (KMnO4), a powerful oxidizing agent, is readily available without prescription. Tissue contact produces coagulation necrosis and the lethal consequences of oral ingestion are well described, with most deaths because of airway oedema and obstruction or circulatory collapse. Whilst systemic toxicity is reported, its mechanism is unclear, We describe a case of suicidal ingestion ofKMnO(4) followed by acute hepatorenal toxicity resulting in the death of the patient. The clinical course bore close resemblance to that of severe paracetamol overdose. We discuss the pathogenesis of the systemic toxicity ofKMnO(4) and postulate that it is due to oxidative injury from free radicals generated by the absorbed permanganate ion. We recommend that N-acetyl cysteine be given within the first few hours to all patients with potassium permanganate poisoning.
着者Young RJ, Critchley JAJH, Young KK, Freebairn RC, Reynolds AP, Lolin YI
期刊名称HUMAN & EXPERIMENTAL TOXICOLOGY
出版年份1996
月份3
日期1
卷号15
期次3
出版社STOCKTON PRESS
页次259 - 261
国际标準期刊号0144-5952
语言英式英语
关键词acute hepatic failure; acute renal failure; N-acetyl cysteine; poisoning; potassium permanganate
Web of Science 学科类别Toxicology; TOXICOLOGY
