Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 郭志德教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/bja/74.4.373 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/32WOS source URL
其它资讯
摘要We have compared the haemodynamic effects of ephedrine alone with ephedrine and colloid for the treatment of hypotension produced by subarachnoid anaesthesia in 30 patients aged 60-90 yr with fractures of the neck of femur. Group one received ephedrine as an initial bolus dose of 0.2 mg kg(-1) followed by an infusion of 0.5 mg kg(-1) h(-1). Group two received ephedrine and colloid (polygeline, Haemaccel) 8 ml kg(-1). If necessary, up to three rescue bolus doses of ephedrine (0.1 mg kg(-1)) and then colloid solution (8 ml kg(-1)) were given to maintain systolic arterial pressure (SAP) at >75% of baseline. Arterial pressure was measured by automated oscillotonometry, central venous pressure (CVP) by a manometer and cardiac index (CI), stroke index (SI) and heart rate (HR) by transthoracic electrical bioimpedance. Systemic vascular resistance index (SVRI) was derived. In patients receiving ephedrine only, SVRI, CVP and SI decreased and HR increased (P < 0.0001). Five patients in this group required colloid, the effect of which was to restore CVP, increase CI and SI, and decrease HR (P < 0.02). In patients receiving ephedrine and colloid solution, SVRI decreased and CI, Si and HR increased (P < 0.0001). Ephedrine was not a potent arterial vasoconstrictor and SAP was maintained mainly by increases in SI and HR.
着者CRITCHLEY LAH, STUART JC, CONWAY F, SHORT TG
期刊名称British Journal of Anaesthesia
出版年份1995
月份4
日期1
卷号74
期次4
出版社PROF SCI PUBL
页次373 - 378
国际标準期刊号0007-0912
电子国际标準期刊号1471-6771
语言英式英语
关键词ANESTHETIC TECHNIQUES, SUBARACHNOID; CARDIOVASCULAR SYSTEM, EFFECTS; COMPLICATIONS, HYPOTENSION; SYMPATHETIC NERVOUS SYSTEM, EPHEDRINE
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY
