Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 洪秀治教授 (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1093/bja/68.1.64 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/32WOS source URL
其它资讯
摘要The induction dose requirements of propofal were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1.6, 1.8, 2.0, 2.2, 2.4 and 2.6 mg kg-1). ED50 and ED95 for loss of eyelash reflex (LER) and acceptance of face mask (AFM) were determined using probit analysis. ED50 and ED95 for both LER and AFM were greatest in group A, less in B and smallest in C; ED95 (AFM) for groups A, B and C were 2.88 (2.55-3.36), 2.53 (2.31-2.86), and 2.20 (2.02-2.46) mg kg-1, respectively. This probably represented their effective induction dose. The incidence of apnoea was dose related, but not pain on injection.
着者AUN CST, SHORT SM, LEUNG DHY, OH TE
期刊名称British Journal of Anaesthesia
出版年份1992
月份1
日期1
卷号68
期次1
出版社PROF SCI PUBL
页次64 - 67
国际标準期刊号0007-0912
电子国际标準期刊号1471-6771
语言英式英语
关键词ANESTHESIA, PEDIATRIC; ANESTHETICS INTRAVENOUS, PROPOFOL; ED95; POTENCY, DOSE RESPONSE, ED50
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY
