DISPOSITION OF PROPOFOL AT CESAREAN-SECTION AND IN THE POSTPARTUM PERIOD
Publication in refereed journal


香港中文大学研究人员 ( 现职)

Professor Tony GIN (麻醉及深切治疗学系)

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数位物件识别号 (DOI) http://dx.doi.org/10.1093/bja/67.1.49

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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/25WOS source URL

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摘要We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg-1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Ceasarean section group had a total body clearance of (median) 31.5 (range 24.4-53.3) ml min-1 kg-1, apparent volume of distribution at steady state 5.10 (2.46-6.61) litre kg-1 and mean residence time 161 (52.3-http://aims.cuhk.edu.hk/converis/portal/Publication/251) min; values for the postpartum group were 33.8 (21.5-47.2) ml min-1 kg-1, 5.17 (3.47-8.09) litre kg-1 and 163 (92.3-238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62-0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28-2.29%) compared with umbilical plasma (2.08-3.88%) (P < 0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range of 0.05-0.11-mu-g ml-1 at 4 h.

着者GIN T, YAU G, JONG W, TAN P, LEUNG RKW, CHAN K
期刊名称British Journal of Anaesthesia
出版年份1991
月份7
日期1
卷号67
期次1
出版社PROF SCI PUBL
页次49 - 53
国际标準期刊号0007-0912
电子国际标準期刊号1471-6771
语言英式英语

关键词ANESTHESIA; ANESTHETICS, INTRAVENOUS; OBSTETRIC; PHARMACOKINETICS; PREGNANCY; PROPOFOL; PUERPERIUM
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY