Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁廷勋教授 (儿科学系) |
| 陈重娥教授 (内科及药物治疗学系) |
| 林伟基教授 (化学病理学系) |
| 黄永坚教授 (儿科学系) |
| 伍楚贤教授 (内科及药物治疗学系) |
| 江碧珊教授 (内科及药物治疗学系) |
| 李颂仪女士 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1399-3038.2008.00835.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
其它资讯
摘要Airway sensitization requires the expression of prostanoid DP receptor in mice. Recent studies reported that polymorphisms in the gene encoding prostanoid DP receptor (PTGDR) were associated with asthma in White people and Black people, but this association could not be replicated among Latinos and Koreans. This study investigated the association between asthma-related traits and six single nucleotide polymorphisms (SNPs) of PTGDR in Chinese children, consisted of 30http://aims.cuhk.edu.hk/converis/portal/Publication/8 asthmatics and 36http://aims.cuhk.edu.hk/converis/portal/Publication/8 non-allergic controls. Plasma total and aeroallergen-specific immunoglobulin E were measured by immunoassays. PTGDR SNPs were determined by multiplex SNaPshot (TM) genotyping. All polymorphic markers followed Hardy-Weinberg equilibrium except G1044A in the controls (p = 0.021). The linkage disequilibrium (LD) scores for these SNPs were moderate to high, and in particular, T-549C and C-441T were in strong LD. Significant interethnic variations in PTGDR alleles and haplotypes (up to 41%) were found in our subjects when compared with White people or Latinos. Asthma diagnosis, atopy and aeroallergen sensitization did not differ among children with different PTGDR genotypes (p > 0.15 for all). Linear regression showed weakly significant associations between T-197C and G1044A of PTGDR and spirometric variables. PTGDR haplotypes were not associated with asthma and atopy phenotypes (p > 0.09 for all). Our results do not support PTGDR to be a major candidate gene for asthma traits in Chinese children.
着者Leung TF, Li CY, Kong APS, Chan IHS, Ng MCY, Chan MHM, So WY, Wong GWK, Lam CWK, Chan JCN
期刊名称Pediatric Allergy and Immunology
出版年份2009
月份9
日期1
卷号20
期次6
出版社Wiley: 12 months
页次556 - 562
国际标準期刊号0905-6157
电子国际标準期刊号1399-303http://aims.cuhk.edu.hk/converis/portal/Publication/8
语言英式英语
关键词asthma; atopy; haplotype; polymorphism; prostanoid DP receptor
Web of Science 学科类别Allergy; ALLERGY; Immunology; IMMUNOLOGY; Pediatrics; PEDIATRICS
