Recent advances in fetal nucleic acids in maternal plasma
Publication in refereed journal


香港中文大学研究人员 ( 现职)

卢煜明教授 (化学病理学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1369/jhc.4R6362.2005

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/36WOS source URL

其它资讯

摘要The discovery of cell-free fetal DNA in maternal plasma in 1997 has opened up new possibilities for noninvasive prenatal diagnosis. Circulating fetal DNA molecules have been detected in maternal plasma from the first trimester onwards and can be robustly detected using a variety of molecular methods. This approach has been used for the prenatal investigation of sex-linked diseases, fetal RhD status, and prenatal exclusion of beta-thalassemia major. Recently, fetal RNA has also been found in maternal plasma. Such fetal RNA has been shown to originate from the placenta and to be remarkably stable. The use of microarray-based approaches has made it feasible to rapidly generate new circulating RNA markers. It is hoped that further developments in this field will make the routine and widespread practice of noninvasive nucleic acid-based prenatal diagnosis for common pregnancy-associated disorders feasible in the near future.

着者Lo YMD
会议名称14th Workshop on Fetal Cells and Fetal DNA
会议开始日17.04.2004
会议完结日18.04.2004
会议地点Jena
期刊名称Journal of Histochemistry and Cytochemistry
出版年份2005
月份3
日期1
卷号53
期次3
出版社SAGE PUBLICATIONS LTD
页次293 - 296
国际标準期刊号0022-1554
电子国际标準期刊号1551-5044
语言英式英语

关键词noninvasive prenatal diagnosis; plasma DNA; plasma RNA
Web of Science 学科类别Cell Biology; CELL BIOLOGY