Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 韦妙宜教授 (那打素护理学院) |
| 江绍佳教授 (生命科学学院) |
| 徐国荣教授 (生物医学学院) |
| 卢煜明教授 (化学病理学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 冯国培教授 (生物医学学院) |
| 陈浩然教授 (生命科学学院) |
| 罗?业教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1109/IEMBS.2005.1616242 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要An outbreak of severe acute respiratory syndrome (SARS) occurred in China and the first case emerged in mid November 2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/02. The etiologic agent of this disease was found to be a previously unknown coronavirus, SARS-CoV. The detailed pathology of SARS-CoV infection and the host response to the viral infection are still not known. The 3a gene encodes a non-structural viral protein which is predicted to be a transmembrane protein. In this study, we showed that the 3a protein was localized to the endoplasmic reticulum (ER) in 3a-transfected monkey kidney Vero E6 cells. In vitro experiments of chromatin condensation and DNA fragmentation suggest that the 3a protein may trigger apoptosis. Our data show that over-expression of a single SARS-CoV protein can induce apoptosis in vitro. Thus GFP-3a fusion protein could also be used as a biosensor for monitoring the cytopathic features of SARS infection, e.g. lymphopenia, in animal model systems, similar to nucleocapsid and 7a proteins.
着者Waye MMY, Law PTW, Wong CH, Au TCC, Chuck CP, Kong SK, Chan PKS, To KF, Lo AWI, Chan JYW, Suen YK, Chan HYE, Fung KP, Sung JJY, Lo YMD, Tsui SKW
会议名称27th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
会议开始日31.http://aims.cuhk.edu.hk/converis/portal/Publication/08.2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/05
会议完结日http://aims.cuhk.edu.hk/converis/portal/Publication/03.http://aims.cuhk.edu.hk/converis/portal/Publication/09.2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/05
会议地点Shanghai
会议国家中国
期刊名称PROCEEDINGS OF THE 2http://aims.cuhk.edu.hk/converis/portal/Publication/0TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 2http://aims.cuhk.edu.hk/converis/portal/Publication/0, PTS 1-6
详细描述ed. by Scientific Committee of IEEE.\n\nTo ORKTS: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=1616242&isnumber=339http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/05
月份1
日期1
出版社IEEE
页次7482 - 7485
国际标準书号http://aims.cuhk.edu.hk/converis/portal/Publication/0-78http://aims.cuhk.edu.hk/converis/portal/Publication/03-874http://aims.cuhk.edu.hk/converis/portal/Publication/0-6
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/094-687X
语言英式英语
Web of Science 学科类别Engineering; Engineering, Biomedical
