Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1515/CCLM.2002.169 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/26WOS source URL
其它资讯
摘要The recent studies in circulating nucleic acids have brought about a new dimension to medical diagnostics. In oncology, various tumorassociated molecular alterations have been detected in the plasma/serum of cancer patients. These findings have important implications for the diagnosis, prognostication and monitoring of many types of malignancies. In pregnancy, the discovery of fetal DNA in maternal circulation has opened up a new source of fetal genetic material for noninvasive analysis for numerous fetal conditions and detection of certain pregnancyassociated disorders. The measurement of circulating DNA has also found potential application in the posttreatment monitoring of transplant patients and the assessment and prognostication of trauma patients. Although much attention has focused on circulating DNA, the knowledge of its biology is still at an early stage. For example, the origin and mechanisms of release of circulating DNA remain to be elucidated. The eventual clinical application of circulating DNA technology would also require the thorough elucidation of preanalytical factors that may affect its measurement in clinical laboratories.
着者Lui YYN, Lo YMD
会议名称9th Asian Pacific Congress of Clinical Biochemistry
会议开始日09.03.2002
会议完结日14.03.2002
会议地点NEW DELHI
期刊名称Clinical Chemistry and Laboratory Medicine
出版年份2002
月份1
日期1
卷号40
期次10
出版社WALTER DE GRUYTER & CO
页次962 - 968
国际标準期刊号1434-6621
电子国际标準期刊号1437-4331
语言英式英语
关键词molecular diagnostics; nucleic acids : circulating; preanalytical variables
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
