基本信息

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李娟
职称：讲师 性别：女
职务： 办公电话： 化学化工大楼A-303
移动电话： 家庭电话：
家庭住址： 隐藏 电子邮箱：juanli@xtu.edu.cn

工作学习经历

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2014/12-今 湘潭大学化学学院药学教研室
2008/09-2014/12 华中农业大学 动物医学院 药物代谢、残留、药理学与毒理学方向博士
2006/02-2008/06 武汉大学 药学院 药学 获理学学士学位
2004/09-2008/06 华中农业大学 动物科技学院 动物科学 获学士学位



主讲课程

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药理学
研究方向

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药物代谢、毒理学与药理学
主要学术成果

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科研项目
1.湘潭大学自然科学基金，15XZX18，热敏聚合物对人脐静脉内皮细胞生物相容性研究，2016/01-2017/12，在研，主持
2.湖南省教育厅科学研究项目，15C1331，自由基介导的维格列汀引起人肾小管上皮细胞损伤的机制研究，2015/09-2017/12，在研，主持
3.湘潭大学科研启动基金，15QDZ14，DPP-4抑制剂维格列汀致人肾小管上皮细胞株(HK-2)损伤的分子机理，2015/01-2017/12，在研，主持
4.国家自然科学基金面上项目，**，喹噁啉类化合物肾上腺毒性机制的研究，2013/01-2016/12，在研，参加
发表文章
1. Yuejia Ji, Mengxiang Zhu, Yu Gong, Haoyu Tang*, Juan Li*, Yi Cao, Thermoresponsive Polymers with Lower Critical Solution Temperature- or Upper Critical Solution Temperature-Type Phase Behaviour Do Not Induce Toxicity to Human Endothelial Cells, Basic & Clinical Pharmacology & Toxicology, in press （DOI: 10.1111/bcpt.12643）. (IF:3.097)
2. Yu Gong, Yuejia Ji, Fang Liu, Juan Li*, Yi Cao*. Cytotoxicity, oxidative stress and inflammation induced by ZnO nanoparticles in endothelial cells: interaction with palmitate or lipopolysaccharide. Journal of Applied Toxicology, in press (DOI: 10.1002/jat.3415).
3. Juan Li, Lingli Huang, Xu Wang, Yuanhu Pan, Zhaoying Liu, Dongmei Chen, Yanfei Tao, Zonghui Yuan, Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp. Food and Chemical Toxicology. 2014, 69, 109-119. (IF:3.010, 二区)
4. Juan Li, Lingli Huang, Yuanhu Pan, Dongmei Chen, Xu Wang, Ijaz Ahmad, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Tissue depletion of quinocetone and its five major metabolites in pigs, broilers and carp fed quinocetone premix. Journal of Agricultural and Food Chemistry. 2014, 62, 10348-10356. (IF:3.107, 一区)
5. Yi Cao*, Juan Li, Fang Liu, Xiyue Li, Qin Jiang, Shanshan Cheng, Yuxiu Gu, Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review, environmental toxicology and pharmacology, doi: 10.1016/j.etap.2016.07.023, 2016.
6. Yi Cao*, Jimin Long, Yuejia Ji, Gui Chen, Yuexin Shen, Yu Gong & Juan Li. Foam cell formation by particulate matter (PM) exposure: a review. Inhalation Toxicology, 2016, 28(13): 583-590.
7. Qinghua Wu, Xu Wang, Dan Wan, Juan Li, Zonghui Yuan. Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival. Cellular Signalling. 2014, 26, 2951-2960. (IF:4.471,二区)
8. Xu Wang, Huahai Zhang, Lingli Huang, Yuanhu Pan, Juan Li, Dongmei Chen, Guyue Cheng, Haihong Hao, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Deoxidation rates play critical role in DNA damage of important synthetic drugs, quinoxaline 1,4-dioxides. Chemical Research in Toxicology.2015, 28(3):470-481. (IF:4.190,一区)
9. Lingli Huang, Fujun Yin, Yuanhu Pan, Dongmei Chen, Juan Li, Dan Wan, Zhenli Liu, Zonghui Yuan. Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats. Journal of Agricultural and Food Chemistry. 2015, 63(44), 9839-9849. (IF:3.107, 一区)
10. Xu Wang, Dan Wan, Awais Ihsan, Qianying Liu, Guyue Cheng, Juan Li, Zhenli Liu, Zonghui Yuan. Mechanism of adrenocortical toxicity induced by quinocetone and its bidesoxy-quinocetone metabolite in porcine adrenocortical cells in vitro. Food and Chemical Toxicology. 2015, 84, 115-124.(IF:3.010, 二区)
11. Ijaz Ahmad, Haihong Hao, Lingli Huang, Pascal Sanders, Xu Wang, Dongmei Chen, Yanfei Tao, Shuyu Xie, Xiuhua Kuang, Juan Li, Dan Wan, Zonghui Yuan. Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureuscausing septicemia in cattle. Frontiers in Microbiology 6:588. doi: 10.3389/fmicb.2015.00588.(IF:3.941, 二区)
12. Dan Wan, Lingli Huang, Yuanhu Pan,Qinghua Wu, Dongmei Chen, Yanfei Tao, Xu Wang, Zhenli Liu, Juan Li, Liye Wang and Zonghui Yuan. Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry, and online radiometric detection. Journal of Agricultural and Food Chemistry. 2014, 62 (1), 288-296. (IF:3.107, 一区)
13. Juan Li, Lingli Huang, Dongmei Chen, Yuanhu Pan, Yanfei Tao, Zonghui Yuan. Disposition of [3H]quinocetone in rats following oral administration. The Second Sino-UK International Meeting on Animal Production and Disease Control & Doctoral Students Forum on Veterinary Medicine, P31. 2011.10.
14. Min Yao, Menghong Dai, Zhaoying Liu, Wenlong Cui, Daoyuan Li, Huahai Zhang, Juan Li, Yahui Liu, Zonghui Yuan. mRNA expression profiles of P450 3A enzymes in the liver and small intestine of the domestic pig. Research in Veterinary Science. 2012, 93(1), 360-365. (一区)

专利
氚标记和氘标记喹烯酮的制备方法。申请时间：2012年12月17日。申请号：1.9。
成果鉴定
猪可食性组织中喹烯酮最高残留限量标准制定. 农业部科技成果鉴定为国际领先，2013.12。