林英武，男，1976年6月生，安徽安庆人，南华大学教授，博士生导师。湖南省首届“优秀研究生导师”、湖南省121创新人才工程第三层次人选。南华大学“蒸湘****”、“船山****青年人才”。现任化学化工学院院长，南华大学蛋白质结构与功能实验室主任，生物无机化学研究所所长，南华大学侨联副主席。
2005年12月博士毕业于复旦大学化学系，导师黄仲贤教授。2008年7月-2010年6月在美国伊利诺伊大学香槟分校（University of Illinois at Urbana-Champaign,UIUC）化学系从事博士后研究（导师：Prof. Yi Lu）。2013年5月-2013年11月在日本奈良先端科学技术大学院大学（Nara Institute of Science and Technology,NAIST）从事科研合作研究（JSPS访问****，合作者Prof. Shun Hirota）。
主要研究领域：（1）生物无机与蛋白质化学；（2）人工金属酶的分子设计及应用；（3）天然锕系元素的化学生物学效应。
主持国家自然基金面上项目、国家自然基金青年项目、教育部留学回国启动基金、湖南省自然科学****基金、南京大学配位化学国家重点实验室开放基金等。目前，相关科研成果发表于Nature、PNAS、JACS、Angew Chem、Coord Chem Rev、ACS Catalysis、Chem Commun、Dalton Trans、Inorg Chem、Inorg Chem Front、Chem Asian J、ChemBioChem、J Inorg Biochem、中国科学（化学）等国内外期刊累计150余篇，其中第一作者或通讯作者SCI论文80余篇 (H-index 26,https://www.scopus.com/authid/detail.uri?authorId=)。
主要学术任职：国家自然基金（重大培育项目、面上项目、青年项目和地区项目）函评专家、北京市自然科学基金、河北省和浙江省自然科学基金等函评专家。Frontiers in Bioengineering and Biotechnology客座编辑。2017年1月-2020年12月，任国际学术期刊ChemistryOpen 期刊顾问委员会委员。
获奖情况：2016年获得2014年度《中国科学：化学》优秀论文奖；2020年获得“徐元植顺磁共振波谱学优秀青年奖”。
E-mail:linlinying(a)hotmail.com;ywlin(a)usc.edu.cn
研究进展：
2017年：
1. Ying-Wu Lin*. Rational design of metalloenzymes: From single to multiple active sites. Coord Chem Rev 2017, 336:1-27.(Review)（JCR分区:Q1;IF=15.367 ESI高被引论文;Cited by Nature Reviews Chemistry,Trends in Biochemical Sciences, Current Opinion in Chemical Biology, etc)
2. Ying-Wu Lin*. Understanding the choice copper by heme-copper oixdase using biosynthetic models in myoglobin. Inorg Chem Front. 2017, DOI: 10.1039/C6QI00603E.(Highlight)(JCR分区:Q1;IF=5.934）
3.Shan Hu, Bo He, Ke-Jie Du, Xiao-Juan Wang, Shu-Qin Gao, Ying-Wu Lin*. Peroxidase Activity of a c-type Cytochrome b5 in Non-native State is Comparable to that of Native Peroxidases. ChemistryOpen 2017,DOL:10.1002/open. (Inside Front Cover)(IF=2.801）
4. Shan Hu, Bo He, Xiao-Juan Wang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin*. Stabilization of cytochrome b5 by a conserved tyrosine in the secondary sphere of heme active site: A spectroscopic and computational study. Spectrochimica Acta A, 2017, 174:118-123.(IF=2.880）
5.Le-Le Li, Hong Yuan, Fei Liao, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. Rational Design of Artificial Dye-decolorizing Peroxidases using Myoglobin by Engineering Tyr/Trp in the Heme Center. Dalton Transactions, 2017, DOI: 10.1039/C7DT02302B.(IF=4.099）
6. Ming Chen, Zhonghua Wang,^* JinxiaShu, Xiaohui Jiang, Wei Wang, Zhen-Hua Shi and Ying-Wu Lin*. Mimicking a Natural Enzyme System: Cytochrome c Oxidase-Like Activity of Cu₂O Nanoparticles by Receiving Electrons from Cytochrome c. Inorganic Chemistry, 2017, DOI: 10.1021/acs.inorgchem.7b01393.(IF=4.85）
7. Zhen-Hua Shi, Ke-Jie Du,^* Bo He, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin*. Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center. Inorg Chem Front. 2017, DOI: 10.1039/c7qi00384f.(JCR分区:Q1;IF=5.934）
2018年：
8. Shun Hirota* and Ying-Wu Lin*. Design of artificial metalloenzymes/metalloproteins by tuning noncovalent interactions.JBiol InorgChem, 2018, 23(1):7-25. (Invited review to celebrate the 80th birthday of Prof.Helmut Sigel) (IF=2.952)
9. Ying-Wu Lin*. Structure and function of heme proteins regulated by post-translational modifications. Arch Biochem Biophys, 2018, 641:1-30.(Review).(IF=3.118)
10.Xiaojuan Wang, Chuanwan Wei*, Ji-Hu Su, Bo He, Ge-Bo Wen, Ying-Wu Lin* and Yi Zhang*. A Chiral Ligand Assembly that Confers One-electron O2 Reduction Activity for a Cu2+-selective Metallohydrogel. Angew Chem Int Ed, 2018,doi: 10.1002/anie..(JCR分区:Q1;IF=12.959）
11.Hui-Min Cheng, Hong Yuan, Xiao-Juan Wang, Jia-Kun Xu, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan andYing-Wu Lin*. Formation of Cys-heme cross-link in K42C myoglobin under reductive conditions with molecular oxygen. J Inorg Biochem, 2018,182:141-149.(IF=3.063)
12.Lu-Lu Yin, Hong Yuan, Ke-Jie Du, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. Regulation of both structure and function by a de novo designed disulfide bond: A case study of heme protein in myoglobin. Chem Commun, 2018, DOI: 10.1039/C8CC01646A.(JCR分区:Q1;IF=6.164）
13.Hai-Xiao Liu, Lianzhi Li, Bo He, Shu-Qin Gao, Ge-Bo Wen, and Ying-Wu Lin*. Neuroglobin is capable of self-oxidation of methionine64 introduced at the heme axial position. Dalton Transactions, 2018, DOI: 10.1039/C8DT02397B.(IF=4.099）
14.Chuan-Wan Wei, Xiao-Juan Wang^*, Shu-Qin Gao, Ge-Bo Wen, and Ying-Wu Lin*. A La³⁺-selective metallohydrogel with a facile gelator of phenylalanine derivative containing an imidazole group. Dalton Transactions, 2018, DOI: 10.1039/C8DT03557A.(IF=4.099）
15.Lu-Lu Yin, Hong Yuan, Can Liu, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. A Rationally Designed Myoglobin Exhibits a Catalytic dehalogenation Efficiency More than 1000-Fold that of a Native Dehaloperoxidase. ACS Catalysis, 2018, DOI: 10.1021/acscatal.8b02979.(JCR分区:Q1; IF=12.35）
16.Can Liu, Jiakun Xu, Shu-Qin Gao, Bo He, Chuan-Wan Wei^*, Xiao-Juan Wang, Zhonghua Wang,and Ying-Wu Lin*. Green and efficient biosynthesis of indigo from indole by engineered myoglobins.RSC Advances, 2018, 8:33325-33330.
2019年：
17.Hai-Xiao Liu, Lianzhi Li, Xin-Zhi Yang, Chuan-Wan Wei,Hui-Min Cheng, Shu-Qin Gao, Ge-Bo Wen and Ying-Wu Lin*.Enhancement of protein stability by an additional disulfide bond designed in human neuroglobin.RSC Advances, 2019,9:4172-4179.
18.Chuan-Wan Wei, Xiao-Juan Wang^*, Shu-Qin Gao, Ge-Bo Wen,and Ying-Wu Lin*. A phenylalanine derivative containing a 4-pyridine group is able to construct both single crystals and a selective Cu-Ag bimetallohydrogel.Eur J Inorg Chem, 2019, DOI:10.1002/ejic.(Very Important Paper)
19.Can Liu, Hong Yuan, Fei Liao, Chuan-Wan Wei, Ke-Jie Du,Shu-Qin Gao,Xiangshi Tan and Ying-Wu Lin*.Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases. Chem Commun, 2019, DOI: 10.1039/C9CC02714A(JCR分区:Q1;IF=6.164）
20.Xiao-Juan Wang,Chuan-Wan Wei,* Shu-Qin Gao,Bo He,and Ying-Wu Lin*.Assembly of (L+D)-Tryptophan derivatives containing an imidazole group selectively forms a rare purple Ni²⁺-hydrogel.ChemistryOpen. 2019, DOI:10.1002/open..
21.Xiao-Qing Gong, Chuan-Wan Wei, Jia-Kun Xu,Xiao-Juan Wang,* Shu-Qin Gao and Ying-Wu Lin*.Biomimetic Mineralization of Cytochrome c Improves the Catalytic Efficiency and Confers a Functional Multi-enzyme Composite.Catalysts. 2019, in press.(Invited Artical)
22. Ying-Wu Lin*.Rational design of artificial metalloproteins and metalloenzymes with metal clusters.Molecules. 2019,in press(Invited Review)
23. Ping Zhang,Jiakun Xu,Xiao-Juan Wang, Bo He, Shu-Qin Gao, Ying-Wu Lin*. The Third Generation of Artificial Dye-Decolorizing Peroxidase Rationally Designed in Myoglobin,ACS Catalysis, 2019, DOI: 10.1021/acscatal.9b02226.(JCR分区Q1; IF=12.35）
24.Xiao-Feng Wang*, Yangyang Chen, Li-Ping Song, Zhen Fang, Jian Zhang, Fanian Shi, Ying-Wu Lin*, Yunkai Sun, Yue-Biao Zhang*, Jo?o Rocha*.Cooperative Capture of Uranyl Ions by a Carbonyl-Bearing Hierarchical-Porous Cu-Organic Framework.Angew Chem Int Ed, 2019,58(52):18808-18812.（JCR分区:Q1;IF=12.959）（Hot Paper）https://onlinelibrary.wiley.com/doi/full/10.1002/anie.
2020年：
25.Ping Zhang, Hong Yuan, Jiakun Xu,Xiao-Juan Wang, Shu-Qin Gao, Xianshi Tan, Ying-Wu Lin*. A Catalytic Binding Site together with a Distal Tyr in Myoglobin Affords Catalytic Efficiencies Similar to Natural Peroxidases,ACS Catalysis, 2020,10, 1, 891-896 (JCR分区:Q1; IF=12.35）https://pubs.acs.org/doi/10.1021/acscatal.9b05080
26. Ying-Wu Lin*. Uranyl binding to proteins and structural-functional impacts. Biomolecules. 2020,10(3), 457.(JCR分区Q1;IF=4.69）(Review) https://www.mdpi.com/2218-273X/10/3/457
27. Ying-Wu Lin*. Rational design of heme enzymes for biodegradation of pollutants toward a green future.Biotechnol Appl Biochem. 2020 (Invited Review，ESI高被引论文) https://doi.org/10.1002/bab.1788
28. Fei Liao, Jiakun Xu, Jie Luo, Shu-Qin Gao, Xiaojuan Wang and Ying-Wu Lin*.Bioinspired design of artificial peroxidase: Introducing key residues of native peroxidases into F43Y myoglobin with a Tyr-heme cross-link. Dalton Transactions, 2020,http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT00875C?page=search.(This article is part of the themed collection: Dalton Transactions HOT Articles)
29. Lu-Lu Yin ,Jia-Kun Xu, Xiao-Juan Wang,Shu-Qin Gao and Ying-Wu Lin*. Molecular Dynamics Simulation and Kinetic Study of Fluoride Binding to V21C/V66C Myoglobin with a Cytoglobin-like Disulfide Bond. Int. J. Mol. Sci. 2020, 21(7), 2512; https://doi.org/10.3390/ijms**(IF=5.92)
30. Chuan-Wan Wei,Xiao-Qing Gong, Xiao-Juan Wang*,Xin-Zhi Yang, Shu-Qin Gao and Ying-Wu Lin*. A hybrid hydrogel with in situ formed Ag-nanoparticles within 3D networks that exhibits broad antibacterial activities. New J Chem, 2020,44, 7265-7269.
31.Dan Lou, Xi-Chun Liu, Xiao-Juan Wang, Shu-Qin Gao, Ge-Bo Wen, and Ying-Wu Lin*.The Importance of Asn52 in the Structure-Function Relationship of Human Cytochrome c,RSC Advances, 2020,10, 44768 - 44772.
32.林英武*. 血红素蛋白的亚硝酸盐还原酶功能及其生物学意义[J].中国动脉硬化杂志, 2020,(12):1020~1025. （专家论坛栏目）
33.Jie Luo, Ke-Jie Du, Hong Yuan, Chuan-Wan Wei, Jia-Jia Lang, Ge-Bo Wen, Yong-Hua Wang, and Ying-Wu Lin*. Rational Design of an Artificial Nuclease by Engineering a Hetero-Dinuclear Center of Mg-Heme in Myoglobin.ACS Catalysis, 2020,10, 24, 14359–14365 (JCR分区:Q1; IF=12.35）https://pubs.acs.org/doi/10.1021/acscatal.0c04572


2021年：
34.Ying-Wu Lin*.Biodegradation of aromatic pollutants by metalloenzymes: A strcutural-functional-environmental perspective.Coord Chem Rev 2021,https://www.sciencedirect.com/science/article/abs/pii/S0084.(Review)（JCR分区:Q1;IF=22.315)
35.Hai-Xia Wang, Chuan-Wan Wei, Xiao-Juan Wang*,Heng-Fang Xiang,Xin-Zhi Yang,Gui-Long Wu,and Ying-Wu Lin*.A Facile Gelator Based on Phenylalanine Derivative is Capable of Forming Fluorescent Zn-metallohydrogel, Detecting Zn2+ in Aqueous Solutions and Imaging Zn2+ in Living Cells. Spectrochim Acta A: Mol.Biomol.Spect.,2021,https://www.sciencedirect.com/science/article/abs/pii/S**13573?via%3Dihub.
36.Chen, Shun-Fa; Liu, Xi-Chun; Xu, Jia-Kun; Li, Lianzhi*; Lang, Jia-Jia; Wen, Ge-Bo; Ying-Wu Lin*. Conversion of Human Neuroglobin into a Multifunctional Peroxidase by Rational Design.Inorganic Chemistry, 2021, https://pubs.acs.org/doi/10.1021/acs.inorgchem.0c03777.(IF=5.165)
37. Wen-Jie Guo, Jia-Kun Xu*, Jing-Jing Liu, Jia-Jia Lang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin*. Biotransformation of lignin by an artificial heme enzyme designed in myoglobin with a covalently linked heme group.Frontiers in Bioengineering and Biotechnology, 2021, in press (Guest editor).https://www.frontiersin.org/articles/10.3389/fbioe.2021.664388/abstract(IF=5.89)
38. 于帅兵, 王召璐, 庞绪良, 王蕾, 李连之*, 林英武*. 多肽基金属离子传感器.化学进展, 2021,33(3):380-393.http://manu56.magtech.com.cn/progchem/CN/10.7536/PC200611
39.Heng-Fang Xiang, Jia-Kun Xu*, Jiao Liu, Xin-Zhi Yang, Shu-Qin Gao, Ge-Bo Wen and Ying-Wu Lin*.Efficient biodegradation of malachite green by an artificial enzyme designed in myoglobin. RSC Adv., 2021,11, 16090-16095.https://doi.org/10.1039/D1RA02202D
40. Shuaibing Yua, Yan Lia, Lei Gao, Peiran Zhao, Lei Wang, Lianzhi Li*, Ying-Wu Lin*. A highly selective and sensitive Zn2+ fluorescent sensor based on zinc finger-like peptide and its application in cell imaging. Spectrochim Acta A: Mol.Biomol.Spect., 2021, https://doi.org/10.1016/j.saa.2021.120042



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