梅杨

教授/博士生导师
Email:yanmei@hnu.edu.cn；my1986sp@163.com







基本信息
主要以转基因小鼠和基因敲除小鼠模型为研究对象，从事血液生理学、血液病理学及血液肿瘤免疫学的相关研究。目前已在国际主流学术期刊发表科研论文二十余篇，重要科研成果以第一作者、共同第一作者及通讯作者发表在Nature Communications、PNAS、Blood、Leukemia、Haematologica等。曾获得美国血液学会等多项旅行奖(Travel Award)，受邀出席多项国际研讨会并作报告；担任美国血液学会(ASH)会员、细胞生物学学会会员。
主要学术贡献：
（A）揭示先天性免疫反应与骨髓增生异常综合症（MDS）发病的内在联系(Blood. 2014; Blood Advances. 2017; Leukemia. 2018;）
（B）系统性研究mDia蛋白在红细胞发育中的功能及其缺失造成MDS贫血的机制(Haematologica. 2016; Haematologica. 2017; Leukemia. 2018.）
（C）解析mDia蛋白在造血干细胞移植中的生物学功能及调控机制(Nature Communications, 2020）；
（D）探究神经退行性衰老及血液衰老相关疾病中的基因转录调控(Proc Natl Acad Sci U S A. 2012; Proc Natl Acad Sci U S A. 2009; Blood. 2014.）


招生招聘信息：
诚挚欢迎具有生物学、生物医学、动物学等学科背景的优秀本科生、硕/博士生报考，诚邀博士后、助理教授及副教授加盟合作！实验室拟招聘3-5名医学及生物学方向博士后，全年均可入站。学校为助理教授及副教授提供相应科研启动费、安家费及研究生名额。有意者请发送简历至：my1986sp@163.com





教育背景
本科2004 - 2008华中师范大学生命科学学院生物技术专业
博士2008 - 2013厦门大学生命科学学院细胞生物学专业（细胞应激生物学国家重点实验室）


工作履历
2013-2018美国西北大学Feinberg医学院病理系博士后
2018-2020美国西北大学Feinberg医学院病理系研究助理
2020-至今湖南大学生物学院教授/博导（岳麓****）


学术兼职
美国血液学会(ASH)会员
细胞生物学学会会员


研究领域
主要研究方向：
(1)骨髓增生异常综合症疾病模型
(2)红细胞发育及贫血
(3)炎症因子及免疫调节
(4)基因转录与表达调控
(5)造血干细胞生物学


科研项目
2017 Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Co-PI
2020 湖南大学高层次人才启动基金，主持
2020 长沙市自然科学基金，主持
2021 湖南省自然科学基金，主持
2021 国家自然科学基金青年基金，主持
2021 美国血液学会（ASH）Global Research Award，主持


学术成果
代表性科研论文：
First author/Co-first author (#)
1.Yang Mei, Yijie Liu, Peng Ji. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation.Blood Reviews. 2021. 46:100740.(Co-corresponding author) (IF=6.314)
2.Yang Mei^#,Samuel E. Weinberg^#, Lihui Zhao, Adam Frink, Chao Qi, Amir Behdad, Peng Ji, Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza.EClinicalMedicine. 2020, 100475.
(Comment in: Differentiating diagnosis of COVID-19 or influenza in patients based on laboratory data during flu season. Shuwen Liu, Chungen Pan. EClinicalMedicine. 2020. 26, 100475.)
3.Yang Mei, Xu Han, Yijie Liu, Jing Yang, Ronen Sumagin, and Peng Ji. Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment.Nat Communications.2020 Jun 23;11(1):3172. (Co-corresponding author) (IF=11.878)
4.Yang Mei, Baobing Zhao, Ashley A Basiorka, Jing Yang, Lan Cao, JingxinZhang, Alan List, and Peng Ji. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS.Leukemia. 2018,32(4):1023-1033. (IF=10.023)
5.Yang Mei, Gong Feng, Nina Rahimi, Baobing Zhao, Jingxin Zhang, Lan Cao, Jing Yang, Juehua Gao, Yihua Chen, Ronen Sumagin, William A. Muller, Ling Zhang and Peng Ji. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium.Blood Advances. 2017,1:1650-1656. (IF=4.622)
6.Xuehui Li^#,Yang Mei^#, Bowen Yan^#, Eric Vitriol, Suming Huang, Peng Ji, and Yi Qiu. Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2.Haematologica. 2017, 102(6): 984-994. (IF=9.09)
7.Yang Mei, Baobing Zhao, Jing Yang, Juehua Gao, Amittha Wickrema, Dehua Wang, Yihua Chen, Peng Ji. Ineffective Erythropoiesis Caused by Binucleated Late-Stage Erythroblasts in mDia2 Hematopoietic Specific Knockout Mice.Haematologica. 2016, 101(1): e1–e5.(IF=9.09)
8.Ganesan Keerthivasan#,Yang Mei^#, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, and Peng Ji. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) myelodysplastic syndromes.Blood.2014, 124(5): 780-90. (IF=17.543)
(Comment in: Errant innate immune signaling in del(5q) MDS. Starczynowski DT. Blood. 2014, 31; 124(5): 669-71.)
9.Yang Mei^#, Zhanxiang Wang^#, Lei Zhang^#, Yiru Zhang, Xiaoyu Li, Huihui Liu, Jing Ye, and Han You.Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA.Proc Natl Acad Sci U S A. 2012, 109(13): 4898-903. (IF=10.620)
10.Yang Mei^#, Yiru Zhang^#, Kazuo Yamamoto, Wei Xie, Tak W. Mak and Han You. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation.Proc Natl AcadSci U S A. 2009, 106(13): 5153-8. (IF=10.620)
(Editors' Choice, Cell Survival, In the Pink1 with FOXO3a. Elizabeth MA, Sci. Signal. 2009, 2 (65), ec122.)
11.Yijie Liu,Yang Mei, Xu Han, Farida V Korobova, Miguel A Prado, Jing Yang, Zhangli Peng, Joao Paulo, Steven Gygi, Daniel Finley, Peng Ji. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance.Blood. 2020. doi:10.1182/blood.. (IF=17.543)
12.Baobing Zhao,Yang Mei, Lan Cao, Jingxin Zhang, Ronen Sumagin, Jing Yang, Juehua Gao, Matthew J. Schipma, Yanfeng Wang, Chelsea Thorsheim, Liang Zhao, Timothy Stalker, Brady Stein, Qiang Jeremy Wen, John D. Crispino, Charles S. Abrams, and Peng Ji. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.J Clin Invest. 2018, 128(1):125-140.(IF=13.393)
13.Baobing Zhao,Yang Mei, Matthew J. Schipma, Eric Wayne Roth, Reiner Bleher, Joshua Z. Rappoport, AmitthaWickrema, Jing Yang, Peng Ji, Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening,Dev Cell. 2016, 36(5):498-510. (IF=10.129)
14.Lei Zhang,Yang Mei, Nai-yang Fu, Li Guan, Wei Xie, Hui-hui Liu, Chun-dong Yu, Zhenyu Yin, Victor C. Yu, and Han You. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.Proc Natl Acad Sci U S A. 2012, 109(51):20937-42. (IF=10.620)





奖励与荣誉
2007 国家奖学金，教育部
2012 博士研究生国家奖学金，教育部
2015Katten Muchin Rosenman Travel Scholarship award, Northwestern University
2016ASH Abstract Achievement Award, 美国血液学会
2017Katten Muchin Rosenman Travel Scholarship award, Northwestern University
2017Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Northwestern University
2017OPA Professional Development Travel Awards, Northwestern University
2021 湖南省“****”青年项目，湖南省
2021 ASH“全球研究奖”, 美国血液学会