肖朝庭
副教授
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E-mail:xiaocht@126.com







基本信息

肖朝庭，理学博士，副教授，博士生导师，2007年6月毕业于浙江大学获博士学位。2007年7月至2009年10月在浙江大学农业部动物病毒学重点实验室、传染病诊治国家重点实验室人兽共患传染病研究室从事禽冠状病毒研究。2009年11月至2011年7月于湖南农业大学动物医学院从事动物传染病的教学和科研工作。2011年7月至2015年12月赴美国Iowa State University兽医学院从事动物病毒性传染病的研究工作。2016年1月聘为湖南大学副教授。主要研究动物病毒性传染病及人兽共患病的病原学及致病机制。已在Journal of Pineal Research（IF2019=15.221）、Journal of Virology、Journal of General Virology、Transbound Emerg Dis、Poultry Science、Virology、Vaccine、Veterinary Research、Veterinary Microbiology、Virus Research、Plos One等国际知名SCI刊源杂志发表论文40余篇，其中一篇为ESI热点论文，已被引用愈1700次，google scholar h指数为24，i10指数为43。已主持国家自然基金面上项目和湖南省自科基金各1项，主持国家重点研发计划项目-畜禽重要疫病病原学与流行病学研究子课题1项。是Emerging Microbes & Infections、Transboundary and Emerging Diseases、Veterinary Microbiology、Virus Evolution、Scientific Reports、DATABASE-OXFORD、Virologica Sinica、Journal of Biotechnology、Infection Genetics and Evolution、BMC Veterinary Research、Archives of Virology、Journal of Virological Methods等国际SCI杂志审稿专家。






课程名称：普通生物学（I） 课程英文名：
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课程名称：微生物学 课程英文名：
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教育背景
2007年6月毕业于浙江大学获遗传学博士学位
工作履历
2007年7月至2009年10月在浙江大学农业部动物病毒学重点实验室、传染病诊治国家重点实验室人兽共患传染病研究室从事禽冠状病毒研究
2009年11月至2011年7月于湖南农业大学动物医学院从事动物传染病的教学和科研工作
2011年7月至2015年12月赴美国Iowa State University兽医学院从事动物病毒性传染病的研究工作
2016年1月聘为湖南大学副教授
研究领域
1.新发动物病毒性传染病病原鉴定及遗传变异分析
2.重要动物病毒性病原（主要研究对象为圆环病毒、细小病毒、星状病毒、冠状病毒、戊型肝炎病毒）的致病性及致病机制


学术成果
1. Ge M, Hu WQ, Ning KM, Li SY, Xiao CT*.The seroprevalence of the newly identified porcine circovirus type 4 (PCV4) in China investigated by an enzymed-linked immunosorbent assay (ELISA). Transbound Emerg Dis. 2021 Jun 8. doi: 10.1111/tbed.14184. Online ahead of print.（通讯作者）
2. Li JY, Hu WQ, Liu TN, Zhang HH, Opriessnig T, Xiao CT*. Isolation and evolutionary analyses of gout-associated goose astrovirus causing disease in experimentally-infected chickens，Poultry Science，2021,100(2):543-552.(通讯作者）
3. Zhang HH, Hu WQ, Li JY, Liu TN, Zhou JY*, Opriessnig T, Xiao CT*. Novel circovirus species identified in farmed pigs designated as Porcine circovirus 4, Hunan province, China. Transbound Emerg Dis. 2020, 67(3):1057-1061. doi: 10.1111/tbed.13446.（通讯作者）, ESI热点论文
4. Zhang HH, Qiu QG, Liu SJ, Hu WQ, Li JY, Liu TN, PengYS, Ge XY,Xiao CT*. Genomic characterization of a novel astrovirus identified in Amur tigers from a zoo in China. Archives of Virology, 2019, 164(12):3151-3155（通讯作者）
5. Lv SL, Zhang HH, Li JY, Hu WQ, Song YT, Opriessnig T,Xiao CT*. High genetic diversity and recombination events of porcine astrovirus strains identified from ill and asymptomatic pigs in 2017, Hunan Province, China. Virus Genes. 2019, 55(5):673-681.（通讯作者）
6. Zhu Z^#,Xiao CT^#, Fan Y, Cai Z，Lu C，Zhang G，Jiang T，Tan Y, Peng Y. Homologous recombination shapes the genetic diversity of African swine fever viruses. Veterinary Microbiology, 2019, https://doi.org/10.1016/j.vetmic.2019.08.003. (共同第一)
7. Xiao CT*, Luo Z, Lv SL, Opriessnig T, Li RC, Yu XL*. Identification and characterization of multiple porcine astrovirus genotypes in Hunan province, China. Archives of Virology, 2017, 162:943-952.?（通讯作者）
8. Xiao CT, Harmon KM, Halbur PG., Opriessnig T. PCV2d-2 is the predominant type of PCV2 DNA in pig samples collected in the U.S. during 2014–2016. Veterinary Microbiology, 2016, 197:72–77.
9. Xiao CT, Halbur PG, Opriessnig T. Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d. Journal of General Virology, 2015,96(7):1830-41。?
10. Xiao CT, Giménez-Lirola L, Halbur PG, Opriessnig T. Characterization of a novel porcine parvovirus tentatively designated PPV5. PloS One. 2013, 8(6): e65312. doi:10.1371/journal.pone.**.
11. Xiao CT, Halbur PG, Opriessnig T. Molecular evolutionary genetic analysis of emerging parvoviruses identified in pigs. Infection, Genetics and Evolution, 2013,16:369-376.
12. Xiao CT, Giménez-Lirola L, Gerber P, Jiang YH, Halbur P, Opriessnig T. Identification and characterization of novel porcine astroviruses (PAstV) with high prevalence and frequent co-infection of individual pigs with multiple PAstV types. Journal of General Virology. 2013,4(Pt 3):570-582.
13. Xiao CT, Gerber PF, Gimé?nez-Lirola LG, Halbur PG, Opriessnig T. Characterization of porcine parvovirus type 2 (PPV2) which is highly prevalent in the USA. Veterinary Microbiology. 2013, 161(3-4):325-330.
14. Xiao CT, Halbur PG, Opriessnig T. Complete Genome Sequence of a Newly Identified Porcine Astrovirus Genotype 3 Strain US-MO123. Journal of Virology, 2012, 86(23):13126.
15. Xiao CT, Halbur PG, Opriessnig T. Complete genome sequence of a novel porcine circovirus type 2b variant present in cases of vaccine failures in the United States. Journal of Virology. 2012, 86(22):12469.
16. Xiao CT, Gimé?nez-Lirola LG, Halbur PG, Opriessnig T.Increasing porcine PARV4 prevalence with pig age in the U.S. pig population. Veterinary Microbiology. 2012, 160(3-4):290-296.
17. Xiao CT, Gimé?nez-Lirola L, Huang YW, Meng XJ, Halbur PG, Opriessnig T. The prevalence of Torque teno sus virus (TTSuV) is common and increases with the age of growing pigs in the United States. Journal of Virological Methods. 2012,183(1):40-44,
18. Xiao CT, Chu MX, Fu Y, Fang L, Ye SC. Analysis of polymorphism, structure and function of exon 2 of ovine melatonin receptor 1b gene: a clue as to why it lacks expression in sheep. Journal of Pineal Research. 2007, 42(1):97-104. IF2019=15.221.?
19. Xiao CT. Yu XL, Li RC, Zhao D, Li J, Zhang L. Glycoprotein B gene-based phylogenetic analysis of porcine cytomegalovirus isolates. Acta Virologica. 2011, 55(4): 361-363.
20. Xiao CT, Liu ZH, Yu XL, Ge M, Li RC, Xiao BR, Zhou HR. Identification of new defective interfering RNA species associated with porcine reproductive and respiratory syndrome virus infection. Virus Research. 2011, 158(1-2):33-36.
21. Xiao CT, Liu R, Song ZY, Liao M, Zhou JY. Genomic characterization of a proventriculitis-associated infectious bronchitis coronavirus. Virus Genes. 2010, 40(3):421-422.
22. Xiao CT, Zhang MH, Fu Y, Koh HS. Mitochondrial DNA distinction of northeastern China roe deer, Siberian roe deer, and European roe deer, to clarify the taxonomic status of northeastern China roe deer. Biochemical Genetics. 2007, 45(1-2):93-102.
23. Xiao CT, Halbur PG, Opriessnig T. Complete Genome Sequence of a Novel Porcine Parvovirus (PPV) Provisionally Designated PPV5. Genome Announcements. 2013,1(1), e00021-12.
24. Opriessnig T,Xiao CT, Halbur PG. Porcine Astrovirus Type 5-Associated Enteritis in Pigs. J. Comp. Path. 2020, 181, 38-46.
25. Opriessnig T,Xiao CT, Halbur PG, Gerber PF, Matzinger SR, Meng XJ. A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to na?ve pigs under experimental conditions. Vaccine. 2017, 5(2):248-254.
26. Gerber PF,Xiao CT, Lager K, Crawford K, Kulshreshtha V, Cao D, Meng XJ, Opriessnig T. Increased frequency of porcine epidemic diarrhea virus shedding and lesions in suckling pigs compared to nursery pigs and protective immunity in nursery pigs after homologous re-challenge. Veterinary Research. 2016,47(1):118.
27. Gerber PF,Xiao CT, Chen Q, Zhang J, Halbur PG, Opriessnig T.The spray-drying process is sufficient to inactivate infectious porcine epidemic diarrhea virus in plasma. Veterinary Microbiology, 2014,174 (1-2):86-92..
28. Opriessnig T,Xiao CT, Gerber PF, Zhang J, Halbur PG. Porcine epidemic diarrhea virus RNA present in commercial spray-dried porcine plasma is not infectious to na?ve pigs. PLoS One, 2014, 12;9(8):e104766.
29. Opriessnig T,Xiao CT, Gerber PF, Halbur PG. Identification of recently described porcine parvoviruses in archived North American samples from 1996 and association with porcine circovirus associated disease. Veterinary Microbiology, 2014, 173(1-2):9-16.
30. Opriessnig T,Xiao CT, Gerber PF, Halbur PG, Matzinger SR, Meng XJ. The mutant U.S. strain of porcine circovirus type 2 (mPCV2) exhibits similar virulence to the classical PCV2a and PCV2b strains in caesarian-derived colostrum-deprived pigs. Journal of General Virology, 2014,95(Pt 11):2495-503.
31. Gerber P,Xiao CT, Cao DJ, Meng XJ, Opriessnig T. Comparison of real-time reverse transcriptase (RT)-PCR assays for detection of swine hepatitis E virus in fecal samples. Journal of Clinical Microbiology, 2014,52:1045-1051.
32. Jiang YH,Xiao CT, Yin SH, Gerber P, Halbur P, Opriessnig T. High prevalence and genetic diversity of porcine bocaviruses (PBoV) in US pigs and identification of multiple novel PBoVs. Journal of General Virology. 2014, 95(Pt 2):453-465.
33. Yin SH,Xiao CT, Gerber PF, Beach NM, Meng XJ, Halbur PG, Opriessnig T. Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rate of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs. Virus Research, 2013,178(2):445-451.
34. Opriessnig T,Xiao CT, Gerber PF, Halbur PG.Emergence of a novel mutant PCV2b variant associated with clinical PCVAD in two vaccinated pig farms in the U.S. concurrently infected with PPV2. Veterinary Microbiology, 2013, 163(1-2):177-183.
35. Giménez-Lirola LG,Xiao CT, Zavala M, Halbur PG, Opriessnig T. Improving ante mortem diagnosis of Erysipelothrix rhusiopathiae infection by use of oral fluids for bacterial, nucleic acid, and antibody detection. Journal of Microbiological Methods. 2013, 92(2):113-121.
36. Giménez-Lirola LG,Xiao CT, Halbur PG, Opriessnig T. Development of a novel fluorescent microbead-based immunoassay and comparison with three enzyme-linked immunoassays for detection of anti-Erysipelothrix spp. IgG antibodies in pigs with known and unknown exposure. Journal of Microbiological Methods, 2012, 91(1):73-79.
37. Giménez-Lirola LG,Xiao CT, Halbur PG, Opriessnig T. Development and evaluation of an enzyme-linked immunosorbent assay based on a recombinant SpaA protein (rSpaA415) for detection of anti-Erysipelothrix spp. IgG antibodies in pigs. Journal of Microbiological Methods. 2012, 91(1):191-197.
38. Chu M, Xiao C, Feng T, Fu Y, Cao G, Fang L, Di R, Tang Q, Huang D, Ma Y, Li K, Li N. Polymorphisms of KiSS-1 and GPR54 genes and their relationships with litter size in sheep. Molecular Biology Reports. 2012,39(3):3291-3297.
39. Chu MX,Xiao CT, Fu Y, Fang L, Ye SC. PCR-SSCP Polymorphism of Inhibin βA Gene in Some Sheep Breeds. Asian - Australasian Journal of Animal Sciences. 2007, 20(7) : 1023-1029.
40. Mi S, Guo S, Xing C, Xiao C, He B, Wu B, Xia X, Tu C, Gong W. Isolation and characterization of porcine astrovirus 5 from a classical swine fever virus-infected specimen. J Virol. 2020，JVI.01513-20. doi: 10.1128/JVI.01513-20.Epub ahead of print.
41. Opriessnig T, Karuppannan AK, Castro AMMG, Xiao CT. Porcine circoviruses:current status, knowledge gaps and challenges. Virus Res. 2020, 286:198044.doi: 10.1016/j.virusres.2020.198044.
42. Thachil A, Gerber PF,Xiao CT, Huang YW, Opriessnig T. Development and application of an ELISA for the detection of porcine deltacoronavirus IgG antibodies.PLoS One. 2015, 16;10(4):e**. doi: 10.1371/journal.pone.**. eCollection 2015.
43. Opriessnig T, Gerber PF,Xiao CT, Halbur PG, Matzinger SR, Meng XJ.Commercial PCV2a-based vaccines are effective in protecting naturally PCV2b-infected finisher pigs against experimental challenge with a 2012 mutant PCV2. Vaccine, 2014, 2(34):4342-4348.
44. Opriessnig T, Gerber PF,Xiao CT, Mogler M, Halbur PG. A commercial vaccine based on PCV2a and an experimental vaccine based on a variant mPCV2b are both effective in protecting pigs against challenge with a 2013 U.S. variant mPCV2b strain. Vaccine. 2014, 32:230-237.
45. Liu GH, Li RC, Li J, Huang ZB,Xiao CT, Luo W, Ge M, Jiang DL, Yu XL. Seroprevalence of porcine cytomegalovirus and sapovirus infection in pigs in Hunan province, China. Archives of Virology. 2012, 157(3):521-524.
46. Liu GH, Li RC, Huang ZB, Yang J,Xiao CT, Li J, Li MX, Yan YQ, Yu XL. RT-PCR test for detecting porcine sapovirus in weanling piglets in Hunan Province, China. Tropical Animal Health and Production. 2012, 44(7):1335-1339.
47. Gerber PF, Johnson J, Shen H, Striegel D,Xiao CT, Halbur PG, Opriessnig T. Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs. Research in Veterinary Science, 2013, 95(2):775-81.
48. 吕孙良,张慧慧,胡文琴,黎洁玉,宋雅婷,肖朝庭^*.湖南省禽白血病病毒分子流行病学调查及env 基因序列分析.中国兽医学报，2020, 40，1936-1941，1975。(通讯作者)
49. 肖朝庭，时莉，宋翥远，刘然，周继勇.禽传染性支气管炎病毒疫苗株H52的全基因组克隆与分析.中国动物传染病学报, 2009, 17(2):17-23。?
50. 肖朝庭，傅衍，田勇.酿酒酵母细胞表面工程应用研究新进展.微生物学报，2005，25(5): 812-816。?