教授，博士生导师




基本信息
湖南大学化学化工学院教授，博士生导师，化学生物传感与计量学国家重点实验室副主任。发表通讯作者SCI源刊论文百余篇，他引4000余次，单篇最高他引210次，其中影响因子>5.0的论文50余篇，包括J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Anal. Chem.等。承担主持了4项国家自然科学基金项目。湖南省优秀博士毕业论文指导教师，培养的博士生1人获“博士后创新人才支持计划”。
教育背景
1996/9 –1999/6 湖南大学，分析化学，研究生/博士
1993/9 –1996/6 湖南大学，分析化学，研究生/硕士
1989/9 –1993/6 湖南大学，分析化学，本科/学士
工作履历
2017/01-至今，湖南大学，化学生物传感与计量学国家重点实验室副主任
2006/01-至今，湖南大学，教授
2005/07-2005/12，湖南师范大学，教授
2000/07 -2005/07，湖南师范大学，副教授
1999/07-2000/07，湖南师范大学，讲师
研究领域
生物纳米材料的可控合成、生物传感、生物成像
科研项目
国家自然科学基金国家****基金项目，**，2016/01-2020/12，400万，主持
国家自然科学基金面上项目，**，2013/01-2016/12，80万，主持
中华人民共和国教育部新世纪优秀人才支持计划，NCET-11-0121，2012/01-2014/12，50万，主持
湖南省自然科学基金湖南省****基金项目，12JJ1004，2012/01-2014/12，30万，主持
学术成果
近年部分通讯作者论文
2017年
1. Jin-Tao Yi, Ting-Ting Chen, Jia Huo*, and Xia Chu*, Nanoscale zeolitic imidazolate framework-8 for ratiometric fluorescence imaging of MicroRNA in living cells, Analytical Chemistry, 2017, 89, 12351.
2. Yao Cen, Wen-Jing Deng, Yuan Yang, Ru-Qin Yu*, Xia Chu*, A core-shell-shell multifunctional nanoplatform for intracellular tumor-related mrnas imaging and near-infrared light triggered photodynamic-photothermal synergistic therapy, Analytical Chemistry, 2017, 89, 10321.
2016年
1. Yao Cen, Yuan Yang, Ru-Qin Yu, Ting-Ting Chen*, Xia Chu*, A cobalt oxyhydroxide nanoflake-based nanoprobe for the sensitive fluorescence detection of T4 polynucleotide kinase activity and inhibition, Nanoscale, 2016,8, 8202.
2. Xiang-Juan Kong, Shuang Wu, Yao Cen, Ru-Qin Yu, Xia Chu*, "Light-up" sensing of human 8-oxoguanine DNA glycosylase activity by target-induced auto-catalytic DNAzyme-generated rolling circle amplification, Biosensors & Bioelectronics, 2016, 79, 679.
3. Shuang Wu, Xiang-Juan Kong, Yao Cen, Jing Yuan, Ru-Qin Yu and Xia Chu*, Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H₂O₂and glucose, Nanoscale, 2016, 8, 8939.
4. Xiang-Juan Kong, Shuang Wu, Ting-Ting Chen*, Ru-Qin Yu and Xia Chu*, MnO₂-induced synthesis of fluorescent polydopamine nanoparticles for reduced glutathione sensing in human whole blood, Nanoscale, 2016, 8, 15604.
2015年
1. Ting-Ting Chen, Xue Tian, Chen-Li wei Liu, Jia Ge, Xia Chu*, and Yingfu Li, Fluorescence Activation Imaging of Cytochrome c Released from Mitochondria Using Aptameric Nanosensor, Journal of the American Chemical Society, 2015, 137, 982.
2. Jing Yuan, Yao Cen, Xiang-Juan Kong, Shuang Wu, Chen-Liwei Liu, Ru-Qin Yu, and Xia Chu*, MnO₂ Nanosheet-Modified Upconversion Nanosystem for Sensitive Turn-On Fluorescence Detection of H₂O₂ and Glucose in Blood, ACS Applied Materials & Interfaces, 2015, 7, 10548.
3. Shuang Wu, Xiang-Juan Kong, Yao Cen, Ru-Qin Yu and Xia Chu*, Phosphorylation-induced formation of a cytochrome c-peptide complex: a novel fluorescent sensing platform for protein kinase assay, Chemical Communications, 2015, 52, 776.
4. Yao Cen, Jun Tang, Xiang-Juan Kong, Shuang Wu, Jing Yuan, Ru-Qin Yu and Xia Chu*, A cobalt oxyhydroxide-modified upconversion nanosystem for sensitive fluorescence sensing of ascorbic acid in human plasma, Nanoscale, 2015, 7, 13951.
2014年
1. Jia Ge, En-Cai Ou, Ru-Qin Yu * and Xia Chu*, A novel aptameric nanobiosensor based on the self-assembled DNA–MoS₂ nanosheet architecture for biomolecule detection, Journal of Materials Chemistry B, 2014, 2, 625.
2. Yao Cen, Yan-Mei Wu, Xiang-Juan Kong, Shuang Wu, Ru-Qin Yu, and Xia Chu*, Phospholipid-Modified Upconversion Nanoprobe for Ratiometric Fluorescence Detection and Imaging of Phospholipase D in Cell Lysate and in Living Cells, Analytical Chemistry, 2014, 86, 7119.
3. Jia Ge, Liang-Liang Zhang, Si-Jia Liu, Ru-Qin Yu, and Xia Chu*, A Highly Sensitive Target-Primed Rolling Circle Amplification (TPRCA) Method for Fluorescent in Situ Hybridization Detection of MicroRNA in Tumor Cells, Analytical Chemistry, 2014, 86, 1808.
4. Yan-Mei Wu, Yao Cen, Li-Jiao Huang, Ru-Qin Yu and Xia Chu*, Upconversion fluorescence resonance energy transfer biosensor for sensitive detection of human immunodeficiency virus antibodies in human serum, Chemical Communications, 2014, 50, 4759.
5. Jia Ge, Li-Juan Tang, Qiang Xi, Xi-Ping Li, Ru-Qin Yu*, Jian-Hui Jiang and Xia Chu*, A WS₂ nanosheet based sensing platform for highly sensitive detection of T4 polynucleotide kinase and its inhibitors, Nanoscale, 2014, 6, 6866.
6. Jia Ge, Zhi-Mei Huang, Qiang Xi, Ru-Qin Yu, Jian-Hui Jiang and Xia Chu*, A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection, Chemical Communications, 2014, 50, 11879.
2013年
1. Ting-Ting Chen, Yi-Hui Hu, Yao Cen, Xia Chu* and Yi Lu, A Dual-Emission Fluorescent Nanocomplex of Gold-Cluster Decorated Silica Particles for Live Cell Imaging of Highly Reactive Oxygen Species, Journal of the American Chemical Society, 2013, 135, 11595.
2012年
1. Hai-Bo Wang, Ting-Ting Chen, Shuang Wu, Xia Chu*, Ru-Qin Yu, A Novel Biosensing Strategy for Screening G-quadruplex Ligands Based on Graphene Oxide Sheets, Biosensors and Bioelectronics, 2012, 34, 88.
2. Hai-Bo Wang, Shuang Wu, Xia Chu* and Ru-Qin Yu, A sensitive fluorescence strategy for telomerase detection in cancer cells based on T7 exonuclease-assisted target recycling amplification, 2012, Chemical Communications, 2012, 48, 5916.
2011年
1. Hai-Bo Wang, Qing Zhang, Xia Chu*, Ting-Ting Chen, Jia Ge, Ru-Qin Yu, Graphene Oxide-Peptide Conjugate as Intracellular Protease Sensor for Caspase-3 Activation Imaging in Live Cells, Angewandte Chemie International Edition, 2011, 50, 7065.